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Liposarcoma : outcome based on the Scandinavian Sarcoma Group register

Engström, Katarina ; Bergh, Peter ; Gustafson, Pelle LU ; Hultborn, Ragnar ; Johansson, Helena LU ; Löfvenberg, Rickard ; Zaikova, Olga ; Trovik, Clement ; Wahlström, Ola and Bauer, Henrik C F (2008) In Cancer 113(7). p.1649-1656
Abstract
BACKGROUND. The aim was to study the clinicopathological characteristics, treatment, and outcome of liposarcoma in an unselected, population-based patient sample, and to establish whether treatment was according to the Scandinavian Sarcoma Group (SSG) treatment guidelines. METHODS. The SSG Pathology Board reviewed 319 liposarcoma cases reported between 1986 and 1998. After the review, 237 patients without metastasis were analyzed for local recurrence rate in relation to surgical margins, radiotherapy, occurrence of metastasis, and survival. RESULTS. Seventy-eight percent of the patients were primarily operated oil at a sarcoma center, 45% with wide margins. All patients operated on outside the center had nonwide margins. Low-grade lesions... (More)
BACKGROUND. The aim was to study the clinicopathological characteristics, treatment, and outcome of liposarcoma in an unselected, population-based patient sample, and to establish whether treatment was according to the Scandinavian Sarcoma Group (SSG) treatment guidelines. METHODS. The SSG Pathology Board reviewed 319 liposarcoma cases reported between 1986 and 1998. After the review, 237 patients without metastasis were analyzed for local recurrence rate in relation to surgical margins, radiotherapy, occurrence of metastasis, and survival. RESULTS. Seventy-eight percent of the patients were primarily operated oil at a sarcoma center, 45% with wide margins. All patients operated on outside the center had nonwide margins. Low-grade lesions constituted 67% of cases. Despite nonwide surgery, only 58% of high-grade lesions were treated with postoperative radiotherapy. The risk of local recurrence after nonwide surgery, without irradiation, was 47% for high-grade lesions. The estimated 10-year, local recurrence-free and metastasis-free survival in the low-grade group was 87% and 95%, respectively. In the high-grade group, it was 75% and 61%, respectively. Independent adverse prognostic factors for local recurrence were surgery outside a sarcoma center and histological type dedifferentiated liposarcoma. For metastases, they were old age, large tumor size, high grade, and histological type myxoid liposarcoma with a round cell component. Radiotherapy showed significant effect oil local recurrence rate for the same grade and margin. CONCLUSIONS. Patients with liposarcoma should be treated at specialized centers. Postoperative radiotherapy decreases the local recurrence rate. To maintain quality and provide support for further trials, reporting to quality registers is crucial. (Less)
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Contribution to journal
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published
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keywords
Adolescent, Adult, Aged, Aged, 80 and over, Disease-Free Survival, Female, Humans, Liposarcoma/radiotherapy, Male, Middle Aged, Neoplasm Metastasis, Neoplasm Recurrence, Local, Prognosis, Radiotherapy, Adjuvant, Registries, Scandinavian and Nordic Countries, Survival Analysis, Treatment Outcome
in
Cancer
volume
113
issue
7
pages
8 pages
publisher
John Wiley and Sons
external identifiers
  • wos:000259661700022
  • scopus:54049117218
  • pmid:18720363
ISSN
1097-0142
DOI
10.1002/cncr.23784
language
English
LU publication?
yes
id
e5b5a9a7-97a2-44e2-9168-d2e79f850462 (old id 1286807)
date added to LUP
2016-04-01 12:27:29
date last changed
2021-01-06 06:03:52
@article{e5b5a9a7-97a2-44e2-9168-d2e79f850462,
  abstract     = {BACKGROUND. The aim was to study the clinicopathological characteristics, treatment, and outcome of liposarcoma in an unselected, population-based patient sample, and to establish whether treatment was according to the Scandinavian Sarcoma Group (SSG) treatment guidelines. METHODS. The SSG Pathology Board reviewed 319 liposarcoma cases reported between 1986 and 1998. After the review, 237 patients without metastasis were analyzed for local recurrence rate in relation to surgical margins, radiotherapy, occurrence of metastasis, and survival. RESULTS. Seventy-eight percent of the patients were primarily operated oil at a sarcoma center, 45% with wide margins. All patients operated on outside the center had nonwide margins. Low-grade lesions constituted 67% of cases. Despite nonwide surgery, only 58% of high-grade lesions were treated with postoperative radiotherapy. The risk of local recurrence after nonwide surgery, without irradiation, was 47% for high-grade lesions. The estimated 10-year, local recurrence-free and metastasis-free survival in the low-grade group was 87% and 95%, respectively. In the high-grade group, it was 75% and 61%, respectively. Independent adverse prognostic factors for local recurrence were surgery outside a sarcoma center and histological type dedifferentiated liposarcoma. For metastases, they were old age, large tumor size, high grade, and histological type myxoid liposarcoma with a round cell component. Radiotherapy showed significant effect oil local recurrence rate for the same grade and margin. CONCLUSIONS. Patients with liposarcoma should be treated at specialized centers. Postoperative radiotherapy decreases the local recurrence rate. To maintain quality and provide support for further trials, reporting to quality registers is crucial.},
  author       = {Engström, Katarina and Bergh, Peter and Gustafson, Pelle and Hultborn, Ragnar and Johansson, Helena and Löfvenberg, Rickard and Zaikova, Olga and Trovik, Clement and Wahlström, Ola and Bauer, Henrik C F},
  issn         = {1097-0142},
  language     = {eng},
  number       = {7},
  pages        = {1649--1656},
  publisher    = {John Wiley and Sons},
  series       = {Cancer},
  title        = {Liposarcoma : outcome based on the Scandinavian Sarcoma Group register},
  url          = {http://dx.doi.org/10.1002/cncr.23784},
  doi          = {10.1002/cncr.23784},
  volume       = {113},
  year         = {2008},
}