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Role of Insulinlike Growth Factor 1 in Fetal Development and in the Early Postnatal Life of Premature Infants

Hellström, Ann LU ; Ley, David LU ; Hansen-Pupp, Ingrid LU ; Hallberg, Boubou; Ramenghi, Luca A.; Löfqvist, Chatarina; Smith, Lois E H and Hård, Anna Lena (2016) In American Journal of Perinatology 33(11). p.1067-1071
Abstract

The neonatal period of very preterm infants is often characterized by a difficult adjustment to extrauterine life, with an inadequate nutrient supply and insufficient levels of growth factors, resulting in poor growth and a high morbidity rate. Long-term multisystem complications include cognitive, behavioral, and motor dysfunction as a result of brain damage as well as visual and hearing deficits and metabolic disorders that persist into adulthood. Insulinlike growth factor 1 (IGF-1) is a major regulator of fetal growth and development of most organs especially the central nervous system including the retina. Glucose metabolism in the developing brain is controlled by IGF-1 which also stimulates differentiation and prevents apoptosis.... (More)

The neonatal period of very preterm infants is often characterized by a difficult adjustment to extrauterine life, with an inadequate nutrient supply and insufficient levels of growth factors, resulting in poor growth and a high morbidity rate. Long-term multisystem complications include cognitive, behavioral, and motor dysfunction as a result of brain damage as well as visual and hearing deficits and metabolic disorders that persist into adulthood. Insulinlike growth factor 1 (IGF-1) is a major regulator of fetal growth and development of most organs especially the central nervous system including the retina. Glucose metabolism in the developing brain is controlled by IGF-1 which also stimulates differentiation and prevents apoptosis. Serum concentrations of IGF-1 decrease to very low levels after very preterm birth and remain low for most of the perinatal development. Strong correlations have been found between low neonatal serum concentrations of IGF-1 and poor brain and retinal growth as well as poor general growth with multiorgan morbidities, such as intraventricular hemorrhage, retinopathy of prematurity, bronchopulmonary dysplasia, and necrotizing enterocolitis. Experimental and clinical studies indicate that early supplementation with IGF-1 can improve growth in catabolic states and reduce brain injury after hypoxic/ischemic events. A multicenter phase II study is currently underway to determine whether intravenous replacement of human recombinant IGF-1 up to normal intrauterine serum concentrations can improve growth and development and reduce prematurity-associated morbidities.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
fetus, IGF-1, metabolism, postnatal growth, preterm infant, preterm morbidity
in
American Journal of Perinatology
volume
33
issue
11
pages
5 pages
publisher
Thieme Medical Publishers
external identifiers
  • scopus:84986237249
  • wos:000382418800010
ISSN
0735-1631
DOI
10.1055/s-0036-1586109
language
English
LU publication?
yes
id
e5b7f882-b38a-4914-9694-c6685bdc12cf
date added to LUP
2016-12-20 13:58:52
date last changed
2017-09-18 11:32:39
@article{e5b7f882-b38a-4914-9694-c6685bdc12cf,
  abstract     = {<p>The neonatal period of very preterm infants is often characterized by a difficult adjustment to extrauterine life, with an inadequate nutrient supply and insufficient levels of growth factors, resulting in poor growth and a high morbidity rate. Long-term multisystem complications include cognitive, behavioral, and motor dysfunction as a result of brain damage as well as visual and hearing deficits and metabolic disorders that persist into adulthood. Insulinlike growth factor 1 (IGF-1) is a major regulator of fetal growth and development of most organs especially the central nervous system including the retina. Glucose metabolism in the developing brain is controlled by IGF-1 which also stimulates differentiation and prevents apoptosis. Serum concentrations of IGF-1 decrease to very low levels after very preterm birth and remain low for most of the perinatal development. Strong correlations have been found between low neonatal serum concentrations of IGF-1 and poor brain and retinal growth as well as poor general growth with multiorgan morbidities, such as intraventricular hemorrhage, retinopathy of prematurity, bronchopulmonary dysplasia, and necrotizing enterocolitis. Experimental and clinical studies indicate that early supplementation with IGF-1 can improve growth in catabolic states and reduce brain injury after hypoxic/ischemic events. A multicenter phase II study is currently underway to determine whether intravenous replacement of human recombinant IGF-1 up to normal intrauterine serum concentrations can improve growth and development and reduce prematurity-associated morbidities.</p>},
  author       = {Hellström, Ann and Ley, David and Hansen-Pupp, Ingrid and Hallberg, Boubou and Ramenghi, Luca A. and Löfqvist, Chatarina and Smith, Lois E H and Hård, Anna Lena},
  issn         = {0735-1631},
  keyword      = {fetus,IGF-1,metabolism,postnatal growth,preterm infant,preterm morbidity},
  language     = {eng},
  month        = {09},
  number       = {11},
  pages        = {1067--1071},
  publisher    = {Thieme Medical Publishers},
  series       = {American Journal of Perinatology},
  title        = {Role of Insulinlike Growth Factor 1 in Fetal Development and in the Early Postnatal Life of Premature Infants},
  url          = {http://dx.doi.org/10.1055/s-0036-1586109},
  volume       = {33},
  year         = {2016},
}