Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Study of Flare Assessment in Systemic Lupus Erythematosus Based on Paper Patients

Isenberg, D. ; Sturgess, J. ; Allen, E. ; Aranow, C. ; Askanase, A. ; Sang-Cheol, B. ; Bernatsky, S. ; Bruce, I. ; Buyon, J. and Cervera, R. , et al. (2018) In Arthritis Care and Research 70(1). p.98-103
Abstract

Objective: To determine the level of agreement of disease flare severity (distinguishing severe, moderate, and mild flare and persistent disease activity) in a large paper-patient exercise involving 988 individual cases of systemic lupus erythematosus. Methods: A total of 988 individual lupus case histories were assessed by 3 individual physicians. Complete agreement about the degree of flare (or persistent disease activity) was obtained in 451 cases (46%), and these provided the reference standard for the second part of the study. This component used 3 flare activity instruments (the British Isles Lupus Assessment Group [BILAG] 2004, Safety of Estrogens in Lupus Erythematosus National Assessment [SELENA] flare index [SFI] and the... (More)

Objective: To determine the level of agreement of disease flare severity (distinguishing severe, moderate, and mild flare and persistent disease activity) in a large paper-patient exercise involving 988 individual cases of systemic lupus erythematosus. Methods: A total of 988 individual lupus case histories were assessed by 3 individual physicians. Complete agreement about the degree of flare (or persistent disease activity) was obtained in 451 cases (46%), and these provided the reference standard for the second part of the study. This component used 3 flare activity instruments (the British Isles Lupus Assessment Group [BILAG] 2004, Safety of Estrogens in Lupus Erythematosus National Assessment [SELENA] flare index [SFI] and the revised SELENA flare index [rSFI]). The 451 patient case histories were distributed to 18 pairs of physicians, carefully randomized in a manner designed to ensure a fair case mix and equal distribution of flare according to severity. Results: The 3-physician assessment of flare matched the level of flare using the 3 indices, with 67% for BILAG 2004, 72% for SFI, and 70% for rSFI. The corresponding weighted kappa coefficients for each instrument were 0.82, 0.59, and 0.74, respectively. We undertook a detailed analysis of the discrepant cases and several factors emerged, including a tendency to score moderate flares as severe and persistent activity as flare, especially when the SFI and rSFI instruments were used. Overscoring was also driven by scoring treatment change as flare, even if there were no new or worsening clinical features. Conclusion: Given the complexity of assessing lupus flare, we were encouraged by the overall results reported. However, the problem of capturing lupus flare accurately is not completely solved.

(Less)
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; ; and , et al. (More)
; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; ; and (Less)
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Arthritis Care and Research
volume
70
issue
1
pages
6 pages
publisher
John Wiley & Sons Inc.
external identifiers
  • scopus:85038126075
  • pmid:28388813
ISSN
2151-464X
DOI
10.1002/acr.23252
language
English
LU publication?
yes
id
e5d53782-ade5-4d3d-81b7-ec15538e8563
date added to LUP
2018-01-10 12:24:46
date last changed
2024-01-29 08:43:56
@article{e5d53782-ade5-4d3d-81b7-ec15538e8563,
  abstract     = {{<p>Objective: To determine the level of agreement of disease flare severity (distinguishing severe, moderate, and mild flare and persistent disease activity) in a large paper-patient exercise involving 988 individual cases of systemic lupus erythematosus. Methods: A total of 988 individual lupus case histories were assessed by 3 individual physicians. Complete agreement about the degree of flare (or persistent disease activity) was obtained in 451 cases (46%), and these provided the reference standard for the second part of the study. This component used 3 flare activity instruments (the British Isles Lupus Assessment Group [BILAG] 2004, Safety of Estrogens in Lupus Erythematosus National Assessment [SELENA] flare index [SFI] and the revised SELENA flare index [rSFI]). The 451 patient case histories were distributed to 18 pairs of physicians, carefully randomized in a manner designed to ensure a fair case mix and equal distribution of flare according to severity. Results: The 3-physician assessment of flare matched the level of flare using the 3 indices, with 67% for BILAG 2004, 72% for SFI, and 70% for rSFI. The corresponding weighted kappa coefficients for each instrument were 0.82, 0.59, and 0.74, respectively. We undertook a detailed analysis of the discrepant cases and several factors emerged, including a tendency to score moderate flares as severe and persistent activity as flare, especially when the SFI and rSFI instruments were used. Overscoring was also driven by scoring treatment change as flare, even if there were no new or worsening clinical features. Conclusion: Given the complexity of assessing lupus flare, we were encouraged by the overall results reported. However, the problem of capturing lupus flare accurately is not completely solved.</p>}},
  author       = {{Isenberg, D. and Sturgess, J. and Allen, E. and Aranow, C. and Askanase, A. and Sang-Cheol, B. and Bernatsky, S. and Bruce, I. and Buyon, J. and Cervera, R. and Clarke, A. and Dooley, Mary Anne and Fortin, P. and Ginzler, E. and Gladman, D. and Hanly, J. and Inanc, M. and Jacobsen, S. and Kamen, D. and Khamashta, M. and Lim, S. and Manzi, S. and Nived, O. and Peschken, C. and Petri, M. and Kalunian, K. and Rahman, A. and Ramsey-Goldman, R. and Romero-Diaz, J. and Ruiz-Irastorza, G. and Sanchez-Guerrero, J. and Steinsson, K. and Sturfelt, G. and Urowitz, M. and van Vollenhoven, R. and Wallace, D. J. and Zoma, A. and Merrill, J. and Gordon, C.}},
  issn         = {{2151-464X}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{98--103}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Arthritis Care and Research}},
  title        = {{Study of Flare Assessment in Systemic Lupus Erythematosus Based on Paper Patients}},
  url          = {{http://dx.doi.org/10.1002/acr.23252}},
  doi          = {{10.1002/acr.23252}},
  volume       = {{70}},
  year         = {{2018}},
}