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Sensitization to molecular dog allergens in an adult population : Results from the West Sweden Asthma Study

Özuygur Ermis, Saliha Selin ; Borres, Magnus P. ; Basna, Rani LU orcid ; Ekerljung, Linda ; Malmhäll, Carina ; Goksör, Emma ; Wennergren, Göran ; Rådinger, Madeleine ; Lötvall, Jan and Lundbäck, Bo , et al. (2023) In Clinical and Experimental Allergy 53(1). p.88-104
Abstract

Background: As the prevalence of dog allergy rises, component resolved diagnosis might improve the diagnosis, understanding of the clinical outcomes and the effectiveness of immunotherapy. Considering the paucity of data in adults, the current study characterized the patterns of sensitization to dog molecular allergens in an adult population. Methods: Data were derived from the West Sweden Asthma Study, a population-based and representative sample of adults from western Sweden. Of the 2006 subjects clinically examined, 313 participants sensitized to whole dog allergen extract were measured for specific immunoglobulin E (sIgE) levels to Can f 1, Can f 2, Can f 3, Can f 4, Can f 5 and Can f 6 using ImmunoCAP™. Polysensitization was... (More)

Background: As the prevalence of dog allergy rises, component resolved diagnosis might improve the diagnosis, understanding of the clinical outcomes and the effectiveness of immunotherapy. Considering the paucity of data in adults, the current study characterized the patterns of sensitization to dog molecular allergens in an adult population. Methods: Data were derived from the West Sweden Asthma Study, a population-based and representative sample of adults from western Sweden. Of the 2006 subjects clinically examined, 313 participants sensitized to whole dog allergen extract were measured for specific immunoglobulin E (sIgE) levels to Can f 1, Can f 2, Can f 3, Can f 4, Can f 5 and Can f 6 using ImmunoCAP™. Polysensitization was defined as sensitization to ≥3 components. Overlapping sensitization was defined as having concomitant sensitization to at least two dog molecular allergen families (lipocalin, albumin or prostatic kallikrein). Results: Of 313, 218 (70%) subjects tested positive to at least one dog allergen component. Sensitization to Can f 1 (43%) was the most common, followed by Can f 5 (33%) among molecular allergens, while sensitization to lipocalins (56%) was the most common among component families. Polysensitization was found in 22% of all participants and was more common in participants with than in those without asthma. Subjects with asthma were less likely to be monosensitized to Can f 5 than those without asthma. Subjects with asthma had higher IgE levels of Can f 3, Can f 4 and Can f 6 than those without asthma. Overlapping sensitizations also differed between those with asthma and allergic rhinitis and those without. Conclusion: Increased knowledge about the sensitization patterns of dog allergen components can aid in defining their role in asthma and rhinitis. In complex clinical cases of dog allergy, a detailed analysis of dog allergen components can provide additional information on the nature of sensitization.

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publishing date
type
Contribution to journal
publication status
published
subject
in
Clinical and Experimental Allergy
volume
53
issue
1
pages
88 - 104
publisher
Wiley
external identifiers
  • scopus:85137192797
  • pmid:35984703
ISSN
0954-7894
DOI
10.1111/cea.14216
language
English
LU publication?
no
additional info
Publisher Copyright: © 2022 The Authors. Clinical & Experimental Allergy published by John Wiley & Sons Ltd.
id
e5fbb3b6-a524-4178-859c-af828ac14921
date added to LUP
2024-06-03 08:59:30
date last changed
2024-06-17 09:41:49
@article{e5fbb3b6-a524-4178-859c-af828ac14921,
  abstract     = {{<p>Background: As the prevalence of dog allergy rises, component resolved diagnosis might improve the diagnosis, understanding of the clinical outcomes and the effectiveness of immunotherapy. Considering the paucity of data in adults, the current study characterized the patterns of sensitization to dog molecular allergens in an adult population. Methods: Data were derived from the West Sweden Asthma Study, a population-based and representative sample of adults from western Sweden. Of the 2006 subjects clinically examined, 313 participants sensitized to whole dog allergen extract were measured for specific immunoglobulin E (sIgE) levels to Can f 1, Can f 2, Can f 3, Can f 4, Can f 5 and Can f 6 using ImmunoCAP™. Polysensitization was defined as sensitization to ≥3 components. Overlapping sensitization was defined as having concomitant sensitization to at least two dog molecular allergen families (lipocalin, albumin or prostatic kallikrein). Results: Of 313, 218 (70%) subjects tested positive to at least one dog allergen component. Sensitization to Can f 1 (43%) was the most common, followed by Can f 5 (33%) among molecular allergens, while sensitization to lipocalins (56%) was the most common among component families. Polysensitization was found in 22% of all participants and was more common in participants with than in those without asthma. Subjects with asthma were less likely to be monosensitized to Can f 5 than those without asthma. Subjects with asthma had higher IgE levels of Can f 3, Can f 4 and Can f 6 than those without asthma. Overlapping sensitizations also differed between those with asthma and allergic rhinitis and those without. Conclusion: Increased knowledge about the sensitization patterns of dog allergen components can aid in defining their role in asthma and rhinitis. In complex clinical cases of dog allergy, a detailed analysis of dog allergen components can provide additional information on the nature of sensitization.</p>}},
  author       = {{Özuygur Ermis, Saliha Selin and Borres, Magnus P. and Basna, Rani and Ekerljung, Linda and Malmhäll, Carina and Goksör, Emma and Wennergren, Göran and Rådinger, Madeleine and Lötvall, Jan and Lundbäck, Bo and Kankaanranta, Hannu and Nwaru, Bright I.}},
  issn         = {{0954-7894}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{88--104}},
  publisher    = {{Wiley}},
  series       = {{Clinical and Experimental Allergy}},
  title        = {{Sensitization to molecular dog allergens in an adult population : Results from the West Sweden Asthma Study}},
  url          = {{http://dx.doi.org/10.1111/cea.14216}},
  doi          = {{10.1111/cea.14216}},
  volume       = {{53}},
  year         = {{2023}},
}