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The Relationship Between Gene Polymorphisms and Dipping Profile in Patients With Coronary Heart Disease

Wirtwein, Marcin; Melander, Olle LU ; Sjögren, Marketa LU ; Hoffmann, Michal; Narkiewicz, Krzysztof; Gruchala, Marcin and Sobiczewski, Wojciech (2016) In American Journal of Hypertension 29(9). p.1094-1102
Abstract

Background: The aim of this study is to report the relationship between certain single-nucleotide polymorphisms (SNPs) and blunted nighttime blood pressure (BP) fall in patients with coronary artery disease confirmed by coronary angiography. Methods: According to the percentage decrease in mean systolic BP (SBP) and diastolic BP (DBP) during the nighttime period, subjects were classified as dippers or nondippers (nighttime relative SBP or DBP decline ≥10% and <10%, respectively). Genetic risk score (GRS18) was constructed to evaluate additive effect of 18 SNPs for nondipping status. Results: In the present study, 1,345 subjects with coronary heart disease (CHD) were included. During follow-up period (median 8.3 years, interquartile... (More)

Background: The aim of this study is to report the relationship between certain single-nucleotide polymorphisms (SNPs) and blunted nighttime blood pressure (BP) fall in patients with coronary artery disease confirmed by coronary angiography. Methods: According to the percentage decrease in mean systolic BP (SBP) and diastolic BP (DBP) during the nighttime period, subjects were classified as dippers or nondippers (nighttime relative SBP or DBP decline ≥10% and <10%, respectively). Genetic risk score (GRS18) was constructed to evaluate additive effect of 18 SNPs for nondipping status. Results: In the present study, 1,345 subjects with coronary heart disease (CHD) were included. During follow-up period (median 8.3 years, interquartile range 5.3-9.0 years), there were 245 all-cause deaths (18.2%) including 114 cardiovascular deaths (8.5%). There were significant differences in the number of revascularizations between nondippers SBP and DBP and dippers SBP and DBP (48.0% vs. 36.4%, P < 0.01). SNPs of the genes, MIA3, MRAS, PCSK9, SMG6, and ZC3HC1, were related to a higher risk of nondipping SBP and DBP status. Conclusions: In the present study, polymorphisms of genes related to CHD (MIA3, MRAS, PCSK9, SMG6, and ZC3HC1) were associated with nondipping SBP and DBP profile, and GRS18 was associated with nondipping status. In addition, this profile was related to a higher risk of revascularization.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Blood pressure, Coronary artery disease, Dipping, DNA polymorphisms, Hypertension
in
American Journal of Hypertension
volume
29
issue
9
pages
9 pages
publisher
Elsevier
external identifiers
  • scopus:84991383762
  • wos:000385122400014
ISSN
0895-7061
DOI
10.1093/ajh/hpw040
language
English
LU publication?
yes
id
e5ffd2d3-eb4e-4196-8325-09d143cb88d5
date added to LUP
2016-11-18 10:40:18
date last changed
2017-01-01 08:40:03
@article{e5ffd2d3-eb4e-4196-8325-09d143cb88d5,
  abstract     = {<p>Background: The aim of this study is to report the relationship between certain single-nucleotide polymorphisms (SNPs) and blunted nighttime blood pressure (BP) fall in patients with coronary artery disease confirmed by coronary angiography. Methods: According to the percentage decrease in mean systolic BP (SBP) and diastolic BP (DBP) during the nighttime period, subjects were classified as dippers or nondippers (nighttime relative SBP or DBP decline ≥10% and &lt;10%, respectively). Genetic risk score (GRS18) was constructed to evaluate additive effect of 18 SNPs for nondipping status. Results: In the present study, 1,345 subjects with coronary heart disease (CHD) were included. During follow-up period (median 8.3 years, interquartile range 5.3-9.0 years), there were 245 all-cause deaths (18.2%) including 114 cardiovascular deaths (8.5%). There were significant differences in the number of revascularizations between nondippers SBP and DBP and dippers SBP and DBP (48.0% vs. 36.4%, P &lt; 0.01). SNPs of the genes, MIA3, MRAS, PCSK9, SMG6, and ZC3HC1, were related to a higher risk of nondipping SBP and DBP status. Conclusions: In the present study, polymorphisms of genes related to CHD (MIA3, MRAS, PCSK9, SMG6, and ZC3HC1) were associated with nondipping SBP and DBP profile, and GRS18 was associated with nondipping status. In addition, this profile was related to a higher risk of revascularization.</p>},
  author       = {Wirtwein, Marcin and Melander, Olle and Sjögren, Marketa and Hoffmann, Michal and Narkiewicz, Krzysztof and Gruchala, Marcin and Sobiczewski, Wojciech},
  issn         = {0895-7061},
  keyword      = {Blood pressure,Coronary artery disease,Dipping,DNA polymorphisms,Hypertension},
  language     = {eng},
  month        = {09},
  number       = {9},
  pages        = {1094--1102},
  publisher    = {Elsevier},
  series       = {American Journal of Hypertension},
  title        = {The Relationship Between Gene Polymorphisms and Dipping Profile in Patients With Coronary Heart Disease},
  url          = {http://dx.doi.org/10.1093/ajh/hpw040},
  volume       = {29},
  year         = {2016},
}