Negative associations for fasting blood glucose, cholesterol and triglyceride levels with the development of giant cell arteritis
(2020) In Revmatologiya 59(11). p.3229-3236- Abstract
Objectives. To investigate metabolic features that may predispose to GCA in a nested case-control study. Methods. Individuals who developed GCA after inclusion in a population-based health survey (the Malmö Preventive Medicine Project; N ¼ 33 346) were identified and validated through a structured review of medical records. Four controls for every validated case were selected from the database. Results. A total of 76 cases with a confirmed incident diagnosis of GCA (61% female, 65% biopsy positive, mean age at diagnosis 70 years) were identified. The median time from screening to diagnosis was 20.7 years (range 3.0-32.1). Cases had significantly lower fasting blood glucose (FBG) at baseline screening compared with controls [mean 4.7 vs... (More)
Objectives. To investigate metabolic features that may predispose to GCA in a nested case-control study. Methods. Individuals who developed GCA after inclusion in a population-based health survey (the Malmö Preventive Medicine Project; N ¼ 33 346) were identified and validated through a structured review of medical records. Four controls for every validated case were selected from the database. Results. A total of 76 cases with a confirmed incident diagnosis of GCA (61% female, 65% biopsy positive, mean age at diagnosis 70 years) were identified. The median time from screening to diagnosis was 20.7 years (range 3.0-32.1). Cases had significantly lower fasting blood glucose (FBG) at baseline screening compared with controls [mean 4.7 vs 5.1 mmol/l (S.D. overall 1.5), odds ratio (OR) 0.35 per mmol/l (95% CI 0.17, 0.71)] and the association remained significant when adjusted for smoking [OR 0.33 per mmol/l (95% CI 0.16, 0.68)]. Current smokers had a reduced risk of GCA [OR 0.35 (95% CI 0.18, 0.70)]. Both cholesterol [mean 5.6 vs 6.0 mmol/l (S.D. overall 1.0)] and triglyceride levels [median 1.0 vs 1.2 mmol/l (S.D. overall 0.8)] were lower among the cases at baseline screening, with significant negative associations with subsequent GCA in crude and smoking-adjusted models [OR 0.62 per mmol/l (95% CI 0.43, 0.90) for cholesterol; 0.46 per mmol/l (95% CI 0.27, 0.81) for triglycerides]. Conclusion. Development of GCA was associated with lower FBG and lower cholesterol and triglyceride levels at baseline, all adjusted for current smoking, suggesting that metabolic features predispose to GCA.
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- author
- Wadström, Karin LU ; Jacobsson, Lennart LU ; Mohammad, Aladdin J. LU ; Warrington, Kenneth J. ; Matteson, Eric L. and Turesson, Carl LU
- organization
- publishing date
- 2020
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Epidemiology, Giant cell arteritis, Lipids
- in
- Revmatologiya
- volume
- 59
- issue
- 11
- pages
- 8 pages
- publisher
- Meditsiinski Unversitet-Sofia
- external identifiers
-
- scopus:85090361005
- pmid:32240313
- ISSN
- 1310-0505
- DOI
- 10.1093/rheumatology/keaa080
- language
- English
- LU publication?
- yes
- id
- e6439381-95be-4457-bfe5-2afb4a051dcd
- date added to LUP
- 2020-12-28 14:42:47
- date last changed
- 2024-05-02 22:55:12
@article{e6439381-95be-4457-bfe5-2afb4a051dcd,
abstract = {{<p>Objectives. To investigate metabolic features that may predispose to GCA in a nested case-control study. Methods. Individuals who developed GCA after inclusion in a population-based health survey (the Malmö Preventive Medicine Project; N ¼ 33 346) were identified and validated through a structured review of medical records. Four controls for every validated case were selected from the database. Results. A total of 76 cases with a confirmed incident diagnosis of GCA (61% female, 65% biopsy positive, mean age at diagnosis 70 years) were identified. The median time from screening to diagnosis was 20.7 years (range 3.0-32.1). Cases had significantly lower fasting blood glucose (FBG) at baseline screening compared with controls [mean 4.7 vs 5.1 mmol/l (S.D. overall 1.5), odds ratio (OR) 0.35 per mmol/l (95% CI 0.17, 0.71)] and the association remained significant when adjusted for smoking [OR 0.33 per mmol/l (95% CI 0.16, 0.68)]. Current smokers had a reduced risk of GCA [OR 0.35 (95% CI 0.18, 0.70)]. Both cholesterol [mean 5.6 vs 6.0 mmol/l (S.D. overall 1.0)] and triglyceride levels [median 1.0 vs 1.2 mmol/l (S.D. overall 0.8)] were lower among the cases at baseline screening, with significant negative associations with subsequent GCA in crude and smoking-adjusted models [OR 0.62 per mmol/l (95% CI 0.43, 0.90) for cholesterol; 0.46 per mmol/l (95% CI 0.27, 0.81) for triglycerides]. Conclusion. Development of GCA was associated with lower FBG and lower cholesterol and triglyceride levels at baseline, all adjusted for current smoking, suggesting that metabolic features predispose to GCA.</p>}},
author = {{Wadström, Karin and Jacobsson, Lennart and Mohammad, Aladdin J. and Warrington, Kenneth J. and Matteson, Eric L. and Turesson, Carl}},
issn = {{1310-0505}},
keywords = {{Epidemiology; Giant cell arteritis; Lipids}},
language = {{eng}},
number = {{11}},
pages = {{3229--3236}},
publisher = {{Meditsiinski Unversitet-Sofia}},
series = {{Revmatologiya}},
title = {{Negative associations for fasting blood glucose, cholesterol and triglyceride levels with the development of giant cell arteritis}},
url = {{http://dx.doi.org/10.1093/rheumatology/keaa080}},
doi = {{10.1093/rheumatology/keaa080}},
volume = {{59}},
year = {{2020}},
}