Impact of therapy and androgen receptor polymorphism on sperm concentration in men treated for testicular germ cell cancer: a longitudinal study.
(2004) In Human Reproduction 19(6). p.1418-1425- Abstract
- Abstract in Undetermined
BACKGROUND: Testicular cancer (TC) patients have a high survival rate, and the question of post-therapy recovery of sperm production and its dependence on genetic predisposition is of major interest. METHODS: Ejaculates were obtained from 112 TC patients at one or more of the following time points: post-orchidectomy, or 6, 12, 24, 36 and 60 months post-therapy. The lengths of the androgen receptor (AR) function modulating CAG and GGN repeats in leukocyte DNA were also analysed. RESULTS: No significant decrease in sperm concentration was seen in men who received 1-2 cycles of adjuvant chemotherapy (ACT). Radiotherapy (RT) or more than two cycles of chemotherapy (HCT) caused an initial decline in sperm... (More) - Abstract in Undetermined
BACKGROUND: Testicular cancer (TC) patients have a high survival rate, and the question of post-therapy recovery of sperm production and its dependence on genetic predisposition is of major interest. METHODS: Ejaculates were obtained from 112 TC patients at one or more of the following time points: post-orchidectomy, or 6, 12, 24, 36 and 60 months post-therapy. The lengths of the androgen receptor (AR) function modulating CAG and GGN repeats in leukocyte DNA were also analysed. RESULTS: No significant decrease in sperm concentration was seen in men who received 1-2 cycles of adjuvant chemotherapy (ACT). Radiotherapy (RT) or more than two cycles of chemotherapy (HCT) caused an initial decline in sperm concentration, which returned to pre-treatment levels 2-5 years after therapy. In the HCT group, sperm concentration 12-24 months post-treatment (T(12-24)) was inversely correlated with CAG length (rho = -0.72, P = 0.03). The type of treatment, but not the concentration at T(0), was an independent predictor of sperm concentration at T(6) (P < 0.0005) and T(12-24) (P = 0.004). CONCLUSION: ACT did not induce a significant decline in sperm concentration. After HCT and RT, a significant reduction of sperm concentration was observed, recovering to pre-treatment levels 2-5 years post-treatment. In HCT-treated patients, the AR CAG length influenced the recovery of spermatogenesis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/122423
- author
- Eberhard, Jakob LU ; Ståhl, Olof LU ; Giwercman, Yvonne LU ; Cwikiel, Magdalena LU ; Cavallin-Ståhl, Eva LU ; Lundin, Kristina LU ; Flodgren, Per LU and Giwercman, Aleksander LU
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- androgen receptor/chemotherapy/radiotherapy/semen quality/testicular cancer
- in
- Human Reproduction
- volume
- 19
- issue
- 6
- pages
- 1418 - 1425
- publisher
- Oxford University Press
- external identifiers
-
- wos:000221748200028
- pmid:15105386
- scopus:3042636786
- pmid:15105386
- ISSN
- 0268-1161
- DOI
- 10.1093/humrep/deh231
- language
- English
- LU publication?
- yes
- id
- e6b95f6f-b6a3-4f85-a896-545b4cab2cc7 (old id 122423)
- alternative location
- http://humrep.oxfordjournals.org/cgi/content/abstract/19/6/1418
- http://www.ncbi.nlm.nih.gov/pubmed/15105386
- date added to LUP
- 2016-04-01 12:34:46
- date last changed
- 2022-03-13 19:49:16
@article{e6b95f6f-b6a3-4f85-a896-545b4cab2cc7, abstract = {{Abstract in Undetermined<br> BACKGROUND: Testicular cancer (TC) patients have a high survival rate, and the question of post-therapy recovery of sperm production and its dependence on genetic predisposition is of major interest. METHODS: Ejaculates were obtained from 112 TC patients at one or more of the following time points: post-orchidectomy, or 6, 12, 24, 36 and 60 months post-therapy. The lengths of the androgen receptor (AR) function modulating CAG and GGN repeats in leukocyte DNA were also analysed. RESULTS: No significant decrease in sperm concentration was seen in men who received 1-2 cycles of adjuvant chemotherapy (ACT). Radiotherapy (RT) or more than two cycles of chemotherapy (HCT) caused an initial decline in sperm concentration, which returned to pre-treatment levels 2-5 years after therapy. In the HCT group, sperm concentration 12-24 months post-treatment (T(12-24)) was inversely correlated with CAG length (rho = -0.72, P = 0.03). The type of treatment, but not the concentration at T(0), was an independent predictor of sperm concentration at T(6) (P < 0.0005) and T(12-24) (P = 0.004). CONCLUSION: ACT did not induce a significant decline in sperm concentration. After HCT and RT, a significant reduction of sperm concentration was observed, recovering to pre-treatment levels 2-5 years post-treatment. In HCT-treated patients, the AR CAG length influenced the recovery of spermatogenesis.}}, author = {{Eberhard, Jakob and Ståhl, Olof and Giwercman, Yvonne and Cwikiel, Magdalena and Cavallin-Ståhl, Eva and Lundin, Kristina and Flodgren, Per and Giwercman, Aleksander}}, issn = {{0268-1161}}, keywords = {{androgen receptor/chemotherapy/radiotherapy/semen quality/testicular cancer}}, language = {{eng}}, number = {{6}}, pages = {{1418--1425}}, publisher = {{Oxford University Press}}, series = {{Human Reproduction}}, title = {{Impact of therapy and androgen receptor polymorphism on sperm concentration in men treated for testicular germ cell cancer: a longitudinal study.}}, url = {{http://dx.doi.org/10.1093/humrep/deh231}}, doi = {{10.1093/humrep/deh231}}, volume = {{19}}, year = {{2004}}, }