Advanced

Dyskinesia - Advances in the understanding of pathophysiology and possible treatment options

Lindgren, Hanna S. LU ; Angela Cenci, M. LU and Lane, Emma L. LU (2010) In European Neurological Review 5(2). p.34-40
Abstract

The degeneration of nigrostriatal dopaminergic neurons in Parkinson's disease gives rise to tremor and slowness of movement, cardinal motor symptoms of the disease that can be alleviated by the dopamine precursor L-DOPA. Despite this, long-term L-DOPA treatment is hampered by the development of abnormal involuntary movements, i.e. dyskinesia, in the majority of patients. The pathophysiology of dyskinesia is complex and multifactorial, but excessive swings in extracellular dopamine causing aberrant plasticity in dopaminoceptive neurons are attributed a primary role. To date there are few effective treatment alternatives for patients with Parkinson's disease experiencing dyskinesia, representing an unmet therapeutic need in the treatment... (More)

The degeneration of nigrostriatal dopaminergic neurons in Parkinson's disease gives rise to tremor and slowness of movement, cardinal motor symptoms of the disease that can be alleviated by the dopamine precursor L-DOPA. Despite this, long-term L-DOPA treatment is hampered by the development of abnormal involuntary movements, i.e. dyskinesia, in the majority of patients. The pathophysiology of dyskinesia is complex and multifactorial, but excessive swings in extracellular dopamine causing aberrant plasticity in dopaminoceptive neurons are attributed a primary role. To date there are few effective treatment alternatives for patients with Parkinson's disease experiencing dyskinesia, representing an unmet therapeutic need in the treatment strategy of the disease. This article reviews recent findings from both clinical and pre-clinical studies and their impact on the search for novel therapeutic approaches to levodopa-induced dyskinesia.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
4-dihydroxyphenylalanine (L-DOPA), Animal models, Basal ganglia, Dopamine, Dopamine replacement therapy, Dyskinesia, Glutamate, L-3, Noradrenalin, Plasticity, Serotonin
in
European Neurological Review
volume
5
issue
2
pages
7 pages
publisher
Touch Briefings
external identifiers
  • scopus:84858197660
ISSN
1758-3837
DOI
10.17925/ENR.2010.05.02.34
language
English
LU publication?
yes
id
e6cff6fa-bcbf-4be7-a315-fbd9109bb0ce
date added to LUP
2017-04-24 12:52:02
date last changed
2018-05-29 09:53:23
@article{e6cff6fa-bcbf-4be7-a315-fbd9109bb0ce,
  abstract     = {<p>The degeneration of nigrostriatal dopaminergic neurons in Parkinson's disease gives rise to tremor and slowness of movement, cardinal motor symptoms of the disease that can be alleviated by the dopamine precursor L-DOPA. Despite this, long-term L-DOPA treatment is hampered by the development of abnormal involuntary movements, i.e. dyskinesia, in the majority of patients. The pathophysiology of dyskinesia is complex and multifactorial, but excessive swings in extracellular dopamine causing aberrant plasticity in dopaminoceptive neurons are attributed a primary role. To date there are few effective treatment alternatives for patients with Parkinson's disease experiencing dyskinesia, representing an unmet therapeutic need in the treatment strategy of the disease. This article reviews recent findings from both clinical and pre-clinical studies and their impact on the search for novel therapeutic approaches to levodopa-induced dyskinesia.</p>},
  author       = {Lindgren, Hanna S. and Angela Cenci, M. and Lane, Emma L.},
  issn         = {1758-3837},
  keyword      = {4-dihydroxyphenylalanine (L-DOPA),Animal models,Basal ganglia,Dopamine,Dopamine replacement therapy,Dyskinesia,Glutamate,L-3,Noradrenalin,Plasticity,Serotonin},
  language     = {eng},
  number       = {2},
  pages        = {34--40},
  publisher    = {Touch Briefings},
  series       = {European Neurological Review},
  title        = {Dyskinesia - Advances in the understanding of pathophysiology and possible treatment options},
  url          = {http://dx.doi.org/10.17925/ENR.2010.05.02.34},
  volume       = {5},
  year         = {2010},
}