Oral prednisone suppresses allergic but not irritant patch test reactions in individuals hypersensitive to nickel
(2004) In Contact Dermatitis 50(5). p.298-303- Abstract
- A multicentre, randomized, double-blind, crossover study was designed to investigate the effects of prednisone on allergic and irritant patch test reactions. 24 subjects with known allergy to nickel were recruited and patch tested with a nickel sulfate dilution series in aqueous solution, 5% nickel sulfate in petrolatum and 2 dilution series of the irritants nonanoic acid and sodium lauryl sulfate. The subjects were tested x2, both during treatment with prednisone 20 mg oral daily and during placebo treatment. The total number of positive nickel patch test reactions decreased significantly in patients during prednisone treatment. The threshold concentration to elicit a patch test reaction increased and the overall degree of reactivity to... (More)
- A multicentre, randomized, double-blind, crossover study was designed to investigate the effects of prednisone on allergic and irritant patch test reactions. 24 subjects with known allergy to nickel were recruited and patch tested with a nickel sulfate dilution series in aqueous solution, 5% nickel sulfate in petrolatum and 2 dilution series of the irritants nonanoic acid and sodium lauryl sulfate. The subjects were tested x2, both during treatment with prednisone 20 mg oral daily and during placebo treatment. The total number of positive nickel patch test reactions decreased significantly in patients during prednisone treatment. The threshold concentration to elicit a patch test reaction increased and the overall degree of reactivity to nickel sulfate shifted towards weaker reactions. The effect of prednisone treatment on the response to irritants was divergent with both increased and decreased numbers of reactions, although there were no statistically significant differences compared with placebo. It is concluded that oral treatment with prednisone suppresses patch test reactivity to nickel, but not to the irritants tested. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/898890
- author
- Anveden, I ; Lindberg, M ; Andersen, KE ; Bruze, Magnus LU ; Isaksson, Marléne LU ; Liden, C ; Sommerlund, M ; Wahlberg, JE ; Wilkinson, JD and Willis, CM
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- sodium lauryl sulfate, prednisone, placebo, patch test reactivity, nonanoic acid, nickel, corticosteroids, suppression, allergic contact dermatitis
- in
- Contact Dermatitis
- volume
- 50
- issue
- 5
- pages
- 298 - 303
- publisher
- Wiley-Blackwell
- external identifiers
-
- pmid:15209811
- wos:000222204600004
- scopus:3042849251
- pmid:15209811
- ISSN
- 0105-1873
- DOI
- 10.1111/j.0105-1873.2004.00340.x
- language
- English
- LU publication?
- yes
- id
- e6d69979-6f60-4df4-9147-e75c31700133 (old id 898890)
- date added to LUP
- 2016-04-01 12:00:25
- date last changed
- 2022-08-13 17:52:20
@article{e6d69979-6f60-4df4-9147-e75c31700133,
abstract = {{A multicentre, randomized, double-blind, crossover study was designed to investigate the effects of prednisone on allergic and irritant patch test reactions. 24 subjects with known allergy to nickel were recruited and patch tested with a nickel sulfate dilution series in aqueous solution, 5% nickel sulfate in petrolatum and 2 dilution series of the irritants nonanoic acid and sodium lauryl sulfate. The subjects were tested x2, both during treatment with prednisone 20 mg oral daily and during placebo treatment. The total number of positive nickel patch test reactions decreased significantly in patients during prednisone treatment. The threshold concentration to elicit a patch test reaction increased and the overall degree of reactivity to nickel sulfate shifted towards weaker reactions. The effect of prednisone treatment on the response to irritants was divergent with both increased and decreased numbers of reactions, although there were no statistically significant differences compared with placebo. It is concluded that oral treatment with prednisone suppresses patch test reactivity to nickel, but not to the irritants tested.}},
author = {{Anveden, I and Lindberg, M and Andersen, KE and Bruze, Magnus and Isaksson, Marléne and Liden, C and Sommerlund, M and Wahlberg, JE and Wilkinson, JD and Willis, CM}},
issn = {{0105-1873}},
keywords = {{sodium lauryl sulfate; prednisone; placebo; patch test reactivity; nonanoic acid; nickel; corticosteroids; suppression; allergic contact dermatitis}},
language = {{eng}},
number = {{5}},
pages = {{298--303}},
publisher = {{Wiley-Blackwell}},
series = {{Contact Dermatitis}},
title = {{Oral prednisone suppresses allergic but not irritant patch test reactions in individuals hypersensitive to nickel}},
url = {{http://dx.doi.org/10.1111/j.0105-1873.2004.00340.x}},
doi = {{10.1111/j.0105-1873.2004.00340.x}},
volume = {{50}},
year = {{2004}},
}