Assessment of ventricular repolarization instability in terms of T-wave alternans induced by head-down bed-rest immobilization
(2019) In Physiological Measurement 40(10).- Abstract
OBJECTIVE: To assess the effects of different durations of simulated microgravity exposure on ventricular repolarization (VR) in terms of T-wave alternans (TWA) as well as to test whether an increase in VR heterogeneity could be detected once normal gravity was restored. APPROACH: A total of 63 healthy volunteers were recruited in several head-down bed-rest (HDBR) experiments in the context of the European Space Agency bed-rest strategy. TWA is evaluated during the night period using ambulatory ECG recordings, before, during and after long- (60 d), mid- (21 d) and short- (5 d) duration HDBR by the long-term averaging technique. MAIN RESULTS: 5-21 d of exposure to simulated microgravity by means of the HDBR model do not lead to a... (More)
OBJECTIVE: To assess the effects of different durations of simulated microgravity exposure on ventricular repolarization (VR) in terms of T-wave alternans (TWA) as well as to test whether an increase in VR heterogeneity could be detected once normal gravity was restored. APPROACH: A total of 63 healthy volunteers were recruited in several head-down bed-rest (HDBR) experiments in the context of the European Space Agency bed-rest strategy. TWA is evaluated during the night period using ambulatory ECG recordings, before, during and after long- (60 d), mid- (21 d) and short- (5 d) duration HDBR by the long-term averaging technique. MAIN RESULTS: 5-21 d of exposure to simulated microgravity by means of the HDBR model do not lead to a significant increase of cardiac electrical instability in healthy myocardial substrates up to the point of eliciting TWA on the surface ECG. However, TWA indices increased after long-term HDBR exposure, once normal gravity was re-established, indicative of incipient electrical instability on VR at the conclusion of 60 d of HDBR. SIGNIFICANCE: The results of this work underline the importance of focusing future research on immediate effects after long-term microgravity exposure, both simulated by HDBR or from space mission scenarios, once partial gravity conditions are re-established. A deeper insight in the understanding of human body reactions in these scenarios results crucial in the design of future long-duration spaceflight missions, to mitigate any potential risk that can limit astronaut's performance.
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- author
- Martín-Yebra, Alba ; Monasterio, Violeta ; Landreani, Federica ; Laguna, Pablo ; Pablo Martínez, Juan and Caiani, Enrico G.
- publishing date
- 2019-10-30
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Physiological Measurement
- volume
- 40
- issue
- 10
- article number
- 104001
- publisher
- IOP Publishing
- external identifiers
-
- scopus:85074308196
- pmid:31593937
- ISSN
- 0967-3334
- DOI
- 10.1088/1361-6579/ab4c18
- language
- English
- LU publication?
- no
- id
- e6e0ae78-3e29-4e89-94d7-733baef91f32
- date added to LUP
- 2019-11-15 13:22:43
- date last changed
- 2024-09-04 12:46:49
@article{e6e0ae78-3e29-4e89-94d7-733baef91f32, abstract = {{<p>OBJECTIVE: To assess the effects of different durations of simulated microgravity exposure on ventricular repolarization (VR) in terms of T-wave alternans (TWA) as well as to test whether an increase in VR heterogeneity could be detected once normal gravity was restored. APPROACH: A total of 63 healthy volunteers were recruited in several head-down bed-rest (HDBR) experiments in the context of the European Space Agency bed-rest strategy. TWA is evaluated during the night period using ambulatory ECG recordings, before, during and after long- (60 d), mid- (21 d) and short- (5 d) duration HDBR by the long-term averaging technique. MAIN RESULTS: 5-21 d of exposure to simulated microgravity by means of the HDBR model do not lead to a significant increase of cardiac electrical instability in healthy myocardial substrates up to the point of eliciting TWA on the surface ECG. However, TWA indices increased after long-term HDBR exposure, once normal gravity was re-established, indicative of incipient electrical instability on VR at the conclusion of 60 d of HDBR. SIGNIFICANCE: The results of this work underline the importance of focusing future research on immediate effects after long-term microgravity exposure, both simulated by HDBR or from space mission scenarios, once partial gravity conditions are re-established. A deeper insight in the understanding of human body reactions in these scenarios results crucial in the design of future long-duration spaceflight missions, to mitigate any potential risk that can limit astronaut's performance.</p>}}, author = {{Martín-Yebra, Alba and Monasterio, Violeta and Landreani, Federica and Laguna, Pablo and Pablo Martínez, Juan and Caiani, Enrico G.}}, issn = {{0967-3334}}, language = {{eng}}, month = {{10}}, number = {{10}}, publisher = {{IOP Publishing}}, series = {{Physiological Measurement}}, title = {{Assessment of ventricular repolarization instability in terms of T-wave alternans induced by head-down bed-rest immobilization}}, url = {{http://dx.doi.org/10.1088/1361-6579/ab4c18}}, doi = {{10.1088/1361-6579/ab4c18}}, volume = {{40}}, year = {{2019}}, }