Advanced

Plasma autoantibodies against apolipoprotein B-100 peptide 210 in subclinical atherosclerosis.

McLeod, Olga; Silveira, Angela; Nordin Fredrikson, Gunilla LU ; Gertow, Karl; Baldassarre, Damiano; Veglia, Fabrizio; Sennblad, Bengt; Strawbridge, Rona J; Larsson, Malin and Leander, Karin, et al. (2014) In Atherosclerosis 232(1). p.242-248
Abstract
Experimental studies have suggested that autoimmunity is involved in atherosclerosis and provided evidence that both protective and pro-atherogenic immune responses exist. This concept has received support from small clinical studies implicating autoantibodies directed against apolipoprotein B-100 (apoB-100) in human atherosclerosis. We examined circulating autoantibodies directed against native and malondialdehyde (MDA)-modified epitope p210 of apoB-100 (IgG-p210nat and IgM-p210MDA) in relation to early atherosclerosis in a large, European longitudinal cohort study of healthy high-risk individuals.
Please use this url to cite or link to this publication:
@article{e742d3ff-a870-405e-a2e5-c41068513e6f,
  abstract     = {Experimental studies have suggested that autoimmunity is involved in atherosclerosis and provided evidence that both protective and pro-atherogenic immune responses exist. This concept has received support from small clinical studies implicating autoantibodies directed against apolipoprotein B-100 (apoB-100) in human atherosclerosis. We examined circulating autoantibodies directed against native and malondialdehyde (MDA)-modified epitope p210 of apoB-100 (IgG-p210nat and IgM-p210MDA) in relation to early atherosclerosis in a large, European longitudinal cohort study of healthy high-risk individuals.},
  author       = {McLeod, Olga and Silveira, Angela and Nordin Fredrikson, Gunilla and Gertow, Karl and Baldassarre, Damiano and Veglia, Fabrizio and Sennblad, Bengt and Strawbridge, Rona J and Larsson, Malin and Leander, Karin and Gigante, Bruna and Kauhanen, Jussi and Rauramaa, Rainer and Smit, Andries J and Mannarino, Elmo and Giral, Philippe and Humphries, Steve E and Tremoli, Elena and de Faire, Ulf and Ohrvik, John and Nilsson, Jan and Hamsten, Anders},
  issn         = {1879-1484},
  language     = {eng},
  number       = {1},
  pages        = {242--248},
  publisher    = {Elsevier},
  series       = {Atherosclerosis},
  title        = {Plasma autoantibodies against apolipoprotein B-100 peptide 210 in subclinical atherosclerosis.},
  url          = {http://dx.doi.org/10.1016/j.atherosclerosis.2013.11.041},
  volume       = {232},
  year         = {2014},
}