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Hydraulic forces contribute to left ventricular diastolic filling

Maksuti, Elira ; Carlsson, Marcus LU ; Arheden, Håkan LU ; Kovács, Sándor J ; Broomé, Michael and Ugander, Martin LU (2017) In Scientific Reports 7. p.43505-43505
Abstract

Myocardial active relaxation and restoring forces are known determinants of left ventricular (LV) diastolic function. We hypothesize the existence of an additional mechanism involved in LV filling, namely, a hydraulic force contributing to the longitudinal motion of the atrioventricular (AV) plane. A prerequisite for the presence of a net hydraulic force during diastole is that the atrial short-axis area (ASA) is smaller than the ventricular short-axis area (VSA). We aimed (a) to illustrate this mechanism in an analogous physical model, (b) to measure the ASA and VSA throughout the cardiac cycle in healthy volunteers using cardiovascular magnetic resonance imaging, and (c) to calculate the magnitude of the hydraulic force. The physical... (More)

Myocardial active relaxation and restoring forces are known determinants of left ventricular (LV) diastolic function. We hypothesize the existence of an additional mechanism involved in LV filling, namely, a hydraulic force contributing to the longitudinal motion of the atrioventricular (AV) plane. A prerequisite for the presence of a net hydraulic force during diastole is that the atrial short-axis area (ASA) is smaller than the ventricular short-axis area (VSA). We aimed (a) to illustrate this mechanism in an analogous physical model, (b) to measure the ASA and VSA throughout the cardiac cycle in healthy volunteers using cardiovascular magnetic resonance imaging, and (c) to calculate the magnitude of the hydraulic force. The physical model illustrated that the anatomical difference between ASA and VSA provides the basis for generating a hydraulic force during diastole. In volunteers, VSA was greater than ASA during 75-100% of diastole. The hydraulic force was estimated to be 10-60% of the peak driving force of LV filling (1-3 N vs 5-10 N). Hydraulic forces are a consequence of left heart anatomy and aid LV diastolic filling. These findings suggest that the relationship between ASA and VSA, and the associated hydraulic force, should be considered when characterizing diastolic function and dysfunction.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Biomechanical Phenomena, Diastole/physiology, Heart/diagnostic imaging, Humans, Magnetic Resonance Imaging, Models, Cardiovascular, Models, Theoretical, Ventricular Function, Left
in
Scientific Reports
volume
7
pages
43505 - 43505
publisher
Nature Publishing Group
external identifiers
  • pmid:28256604
  • scopus:85014668174
ISSN
2045-2322
DOI
10.1038/srep43505
language
English
LU publication?
yes
id
e761284f-6ae3-4c95-b295-1354a64562e5
date added to LUP
2019-05-13 19:48:23
date last changed
2024-06-12 13:40:40
@article{e761284f-6ae3-4c95-b295-1354a64562e5,
  abstract     = {{<p>Myocardial active relaxation and restoring forces are known determinants of left ventricular (LV) diastolic function. We hypothesize the existence of an additional mechanism involved in LV filling, namely, a hydraulic force contributing to the longitudinal motion of the atrioventricular (AV) plane. A prerequisite for the presence of a net hydraulic force during diastole is that the atrial short-axis area (ASA) is smaller than the ventricular short-axis area (VSA). We aimed (a) to illustrate this mechanism in an analogous physical model, (b) to measure the ASA and VSA throughout the cardiac cycle in healthy volunteers using cardiovascular magnetic resonance imaging, and (c) to calculate the magnitude of the hydraulic force. The physical model illustrated that the anatomical difference between ASA and VSA provides the basis for generating a hydraulic force during diastole. In volunteers, VSA was greater than ASA during 75-100% of diastole. The hydraulic force was estimated to be 10-60% of the peak driving force of LV filling (1-3 N vs 5-10 N). Hydraulic forces are a consequence of left heart anatomy and aid LV diastolic filling. These findings suggest that the relationship between ASA and VSA, and the associated hydraulic force, should be considered when characterizing diastolic function and dysfunction.</p>}},
  author       = {{Maksuti, Elira and Carlsson, Marcus and Arheden, Håkan and Kovács, Sándor J and Broomé, Michael and Ugander, Martin}},
  issn         = {{2045-2322}},
  keywords     = {{Biomechanical Phenomena; Diastole/physiology; Heart/diagnostic imaging; Humans; Magnetic Resonance Imaging; Models, Cardiovascular; Models, Theoretical; Ventricular Function, Left}},
  language     = {{eng}},
  month        = {{03}},
  pages        = {{43505--43505}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Scientific Reports}},
  title        = {{Hydraulic forces contribute to left ventricular diastolic filling}},
  url          = {{http://dx.doi.org/10.1038/srep43505}},
  doi          = {{10.1038/srep43505}},
  volume       = {{7}},
  year         = {{2017}},
}