Characterising the temporal evolution of fixation in human post mortem brain via linear relaxometry modelling – a marker of cross-linking?
(2019) 27.- Abstract
- MRI-based biophysical models are typically validated by comparison to ex-vivo histology of fixed tissue. The fixation process itself and the accompanied autolysis processes strongly modify tissue composition, and lead to MR signal changes, making the validation of biophysical models for in vivo MRI particularly challenging. To better understand the temporal evolution of the fixation process within the whole brain and its influence on MRI parameters, we monitor the temporal evolution of the fixation process of a whole human post-mortem brain using the linear relaxometry model across 15 time-points comprised of one unfixed, in-situ MRI scan and 14 ex-vivo MRI scans at different stages of the fixation process (days 1-93).
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/e76bce0e-4f10-4579-ad17-b722b673ca6c
- author
- Mohammadi, Siawoosh ; Papazoglou, Sebastian ; Mushumba, Herbert ; Ashtarayeh, Mohammad ; Püschel, Klaus ; Helms, Gunther LU ; Callaghan, Martina F ; Weiskopf, Nikolaus and Streubel, Tobias
- organization
- publishing date
- 2019-04-26
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- host publication
- Characterising the temporal evolution of fixation in human post mortem brain via linear relaxometry modelling – a marker of cross-linking?
- volume
- 27
- article number
- 4986
- pages
- 3 pages
- publisher
- International Society for Magnetic Resonance in Medicine
- project
- hMRI Toolbox Team
- language
- English
- LU publication?
- yes
- id
- e76bce0e-4f10-4579-ad17-b722b673ca6c
- alternative location
- http://indexsmart.mirasmart.com/ISMRM2019/PDFfiles/4986.html
- date added to LUP
- 2019-05-30 10:13:35
- date last changed
- 2022-03-16 13:49:12
@inproceedings{e76bce0e-4f10-4579-ad17-b722b673ca6c, abstract = {{MRI-based biophysical models are typically validated by comparison to ex-vivo histology of fixed tissue. The fixation process itself and the accompanied autolysis processes strongly modify tissue composition, and lead to MR signal changes, making the validation of biophysical models for in vivo MRI particularly challenging. To better understand the temporal evolution of the fixation process within the whole brain and its influence on MRI parameters, we monitor the temporal evolution of the fixation process of a whole human post-mortem brain using the linear relaxometry model across 15 time-points comprised of one unfixed, in-situ MRI scan and 14 ex-vivo MRI scans at different stages of the fixation process (days 1-93).}}, author = {{Mohammadi, Siawoosh and Papazoglou, Sebastian and Mushumba, Herbert and Ashtarayeh, Mohammad and Püschel, Klaus and Helms, Gunther and Callaghan, Martina F and Weiskopf, Nikolaus and Streubel, Tobias}}, booktitle = {{Characterising the temporal evolution of fixation in human post mortem brain via linear relaxometry modelling – a marker of cross-linking?}}, language = {{eng}}, month = {{04}}, publisher = {{International Society for Magnetic Resonance in Medicine}}, title = {{Characterising the temporal evolution of fixation in human post mortem brain via linear relaxometry modelling – a marker of cross-linking?}}, url = {{http://indexsmart.mirasmart.com/ISMRM2019/PDFfiles/4986.html}}, volume = {{27}}, year = {{2019}}, }