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Characterising the temporal evolution of fixation in human post mortem brain via linear relaxometry modelling – a marker of cross-linking?

Mohammadi, Siawoosh ; Papazoglou, Sebastian ; Mushumba, Herbert ; Ashtarayeh, Mohammad ; Püschel, Klaus ; Helms, Gunther LU orcid ; Callaghan, Martina F ; Weiskopf, Nikolaus and Streubel, Tobias (2019) 27.
Abstract
MRI-based biophysical models are typically validated by comparison to ex-vivo histology of fixed tissue. The fixation process itself and the accompanied autolysis processes strongly modify tissue composition, and lead to MR signal changes, making the validation of biophysical models for in vivo MRI particularly challenging. To better understand the temporal evolution of the fixation process within the whole brain and its influence on MRI parameters, we monitor the temporal evolution of the fixation process of a whole human post-mortem brain using the linear relaxometry model across 15 time-points comprised of one unfixed, in-situ MRI scan and 14 ex-vivo MRI scans at different stages of the fixation process (days 1-93).
Please use this url to cite or link to this publication:
author
; ; ; ; ; ; ; and
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
host publication
Characterising the temporal evolution of fixation in human post mortem brain via linear relaxometry modelling – a marker of cross-linking?
volume
27
article number
4986
pages
3 pages
publisher
International Society for Magnetic Resonance in Medicine
project
hMRI Toolbox Team
language
English
LU publication?
yes
id
e76bce0e-4f10-4579-ad17-b722b673ca6c
alternative location
http://indexsmart.mirasmart.com/ISMRM2019/PDFfiles/4986.html
date added to LUP
2019-05-30 10:13:35
date last changed
2022-03-16 13:49:12
@inproceedings{e76bce0e-4f10-4579-ad17-b722b673ca6c,
  abstract     = {{MRI-based biophysical models are typically validated by comparison to ex-vivo histology of fixed tissue. The fixation process itself and the accompanied autolysis processes strongly modify tissue composition, and lead to MR signal changes, making the validation of biophysical models for in vivo MRI particularly challenging. To better understand the temporal evolution of the fixation process within the whole brain and its influence on MRI parameters, we monitor the temporal evolution of the fixation process of a whole human post-mortem brain using the linear relaxometry model across 15 time-points comprised of one unfixed, in-situ MRI scan and 14 ex-vivo MRI scans at different stages of the fixation process (days 1-93).}},
  author       = {{Mohammadi, Siawoosh and Papazoglou, Sebastian and Mushumba, Herbert and Ashtarayeh, Mohammad and Püschel, Klaus and Helms, Gunther and Callaghan, Martina F and Weiskopf, Nikolaus and Streubel, Tobias}},
  booktitle    = {{Characterising the temporal evolution of fixation in human post mortem brain via linear relaxometry modelling – a marker of cross-linking?}},
  language     = {{eng}},
  month        = {{04}},
  publisher    = {{International Society for Magnetic Resonance in Medicine}},
  title        = {{Characterising the temporal evolution of fixation in human post mortem brain via linear relaxometry modelling – a marker of cross-linking?}},
  url          = {{http://indexsmart.mirasmart.com/ISMRM2019/PDFfiles/4986.html}},
  volume       = {{27}},
  year         = {{2019}},
}