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Correlations Between Colloidal Stability and Peroxidase Activity of Prussian Blue Nanozymes in Salt Solutions

Péter, Tamás ; Takács, Dóra ; Viczián, Dániel ; Katana, Bojana ; Alsharif, Nizar B. LU and Szilagyi, István (2025) In Journal of Physical Chemistry B 129(27). p.6879-6885
Abstract

Prussian blue (PB) nanozymes have emerged as durable enzyme-mimicking catalysts with broad applications across many fields. Practical uses often involve exposure to salinity that influences their colloidal and catalytic behaviors, yet the specific effects of ions on PB particles are underexplored. This study investigates how electrolyte type and concentration affect the colloidal stability and enzyme-like activity of PB nanozymes using monovalent (NaCl, KCl, CsCl) and multivalent ions (CaCl2, LaCl3). Electrophoresis and dynamic light scattering measurements revealed that both concentration and ion composition significantly affect stability with specific ion adsorption altering charge density and aggregation,... (More)

Prussian blue (PB) nanozymes have emerged as durable enzyme-mimicking catalysts with broad applications across many fields. Practical uses often involve exposure to salinity that influences their colloidal and catalytic behaviors, yet the specific effects of ions on PB particles are underexplored. This study investigates how electrolyte type and concentration affect the colloidal stability and enzyme-like activity of PB nanozymes using monovalent (NaCl, KCl, CsCl) and multivalent ions (CaCl2, LaCl3). Electrophoresis and dynamic light scattering measurements revealed that both concentration and ion composition significantly affect stability with specific ion adsorption altering charge density and aggregation, consistent with the DLVO theory. Findings further indicate that higher ionic strengths compress the electric double layer, improving substrate accessibility and accelerating horseradish peroxidase (HRP)-like catalytic reactions. Remarkably, Cs+ ions substantially boost activity through their unique ability to disrupt water structure and integrate into PB’s lattice. These findings highlight the importance of considering ion specificity when designing PB-containing dispersions for optimal stability and catalytic performance.

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author
; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Physical Chemistry B
volume
129
issue
27
pages
7 pages
publisher
The American Chemical Society (ACS)
external identifiers
  • pmid:40566640
  • scopus:105009016074
ISSN
1520-6106
DOI
10.1021/acs.jpcb.5c01256
language
English
LU publication?
yes
id
e7bed7ee-e138-43fd-880a-8f315dee9763
date added to LUP
2025-12-12 14:07:41
date last changed
2025-12-13 03:00:11
@article{e7bed7ee-e138-43fd-880a-8f315dee9763,
  abstract     = {{<p>Prussian blue (PB) nanozymes have emerged as durable enzyme-mimicking catalysts with broad applications across many fields. Practical uses often involve exposure to salinity that influences their colloidal and catalytic behaviors, yet the specific effects of ions on PB particles are underexplored. This study investigates how electrolyte type and concentration affect the colloidal stability and enzyme-like activity of PB nanozymes using monovalent (NaCl, KCl, CsCl) and multivalent ions (CaCl<sub>2</sub>, LaCl<sub>3</sub>). Electrophoresis and dynamic light scattering measurements revealed that both concentration and ion composition significantly affect stability with specific ion adsorption altering charge density and aggregation, consistent with the DLVO theory. Findings further indicate that higher ionic strengths compress the electric double layer, improving substrate accessibility and accelerating horseradish peroxidase (HRP)-like catalytic reactions. Remarkably, Cs<sup>+</sup> ions substantially boost activity through their unique ability to disrupt water structure and integrate into PB’s lattice. These findings highlight the importance of considering ion specificity when designing PB-containing dispersions for optimal stability and catalytic performance.</p>}},
  author       = {{Péter, Tamás and Takács, Dóra and Viczián, Dániel and Katana, Bojana and Alsharif, Nizar B. and Szilagyi, István}},
  issn         = {{1520-6106}},
  language     = {{eng}},
  number       = {{27}},
  pages        = {{6879--6885}},
  publisher    = {{The American Chemical Society (ACS)}},
  series       = {{Journal of Physical Chemistry B}},
  title        = {{Correlations Between Colloidal Stability and Peroxidase Activity of Prussian Blue Nanozymes in Salt Solutions}},
  url          = {{http://dx.doi.org/10.1021/acs.jpcb.5c01256}},
  doi          = {{10.1021/acs.jpcb.5c01256}},
  volume       = {{129}},
  year         = {{2025}},
}