Discovery of potent and selective small-molecule PAR-2 agonists
Seitzberg, Jimmi Gerner ; Knapp, Anne Eeg ; Lund, Birgitte Winther ; Bertozzi, Sine Mandrup ; Currier, Erika A. ; Ma, Jian Nong ; Sherbukhin, Vladimir ; Burstein, Ethan S. and Olsson, Roger LU
(2008)
In Journal of Medicinal Chemistry
51(18).
p.5490-5493
- Abstract
Proteinase activated receptor-2 plays a crucial role in a wide variety of conditions with a strong inflammatory component. We present the discovery and characterization of two structurally different, potent, selective, and metabolically stable small-molecule PAR-2 agonists. These ligands may be useful as pharmacological tools for elucidating the complex physiological role of the PAR-2 receptors as well as for the development of PAR-2 antagonists.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/e7df098b-a859-4a58-b938-1c315a71a50d
- author
- Seitzberg, Jimmi Gerner
; Knapp, Anne Eeg
; Lund, Birgitte Winther
; Bertozzi, Sine Mandrup
; Currier, Erika A.
; Ma, Jian Nong
; Sherbukhin, Vladimir
; Burstein, Ethan S.
and Olsson, Roger
LU
- publishing date
- 2008-09-25
- type
- Contribution to journal
- publication status
- published
- in
- Journal of Medicinal Chemistry
- volume
- 51
- issue
- 18
- pages
- 4 pages
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- scopus:52449126200
- pmid:18720984
- ISSN
- 0022-2623
- DOI
- 10.1021/jm800754r
- language
- English
- LU publication?
- no
- id
- e7df098b-a859-4a58-b938-1c315a71a50d
- date added to LUP
- 2019-10-02 09:51:02
- date last changed
- 2024-03-04 03:30:34
@article{e7df098b-a859-4a58-b938-1c315a71a50d,
abstract = {{<p>Proteinase activated receptor-2 plays a crucial role in a wide variety of conditions with a strong inflammatory component. We present the discovery and characterization of two structurally different, potent, selective, and metabolically stable small-molecule PAR-2 agonists. These ligands may be useful as pharmacological tools for elucidating the complex physiological role of the PAR-2 receptors as well as for the development of PAR-2 antagonists.</p>}},
author = {{Seitzberg, Jimmi Gerner and Knapp, Anne Eeg and Lund, Birgitte Winther and Bertozzi, Sine Mandrup and Currier, Erika A. and Ma, Jian Nong and Sherbukhin, Vladimir and Burstein, Ethan S. and Olsson, Roger}},
issn = {{0022-2623}},
language = {{eng}},
month = {{09}},
number = {{18}},
pages = {{5490--5493}},
publisher = {{The American Chemical Society (ACS)}},
series = {{Journal of Medicinal Chemistry}},
title = {{Discovery of potent and selective small-molecule PAR-2 agonists}},
url = {{http://dx.doi.org/10.1021/jm800754r}},
doi = {{10.1021/jm800754r}},
volume = {{51}},
year = {{2008}},
}