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Precision cancer medicine : Concepts, current practice, and future developments

Edsjö, Anders LU ; Holmquist, Louise ; Geoerger, Birgit ; Nowak, Frédérique ; Gomon, Georgy ; Alix-Panabières, Catherine ; Ploeger, Carolin ; Lassen, Ulrik ; Le Tourneau, Christophe and Lehtiö, Janne , et al. (2023) In Journal of Internal Medicine 294(4). p.455-481
Abstract

Precision cancer medicine is a multidisciplinary team effort that requires involvement and commitment of many stakeholders including the society at large. Building on the success of significant advances in precision therapy for oncological patients over the last two decades, future developments will be significantly shaped by improvements in scalable molecular diagnostics in which increasingly complex multilayered datasets require transformation into clinically useful information guiding patient management at fast turnaround times. Adaptive profiling strategies involving tissue- and liquid-based testing that account for the immense plasticity of cancer during the patient's journey and also include early detection approaches are already... (More)

Precision cancer medicine is a multidisciplinary team effort that requires involvement and commitment of many stakeholders including the society at large. Building on the success of significant advances in precision therapy for oncological patients over the last two decades, future developments will be significantly shaped by improvements in scalable molecular diagnostics in which increasingly complex multilayered datasets require transformation into clinically useful information guiding patient management at fast turnaround times. Adaptive profiling strategies involving tissue- and liquid-based testing that account for the immense plasticity of cancer during the patient's journey and also include early detection approaches are already finding their way into clinical routine and will become paramount. A second major driver is the development of smart clinical trials and trial concepts which, complemented by real-world evidence, rapidly broaden the spectrum of therapeutic options. Tight coordination with regulatory agencies and health technology assessment bodies is crucial in this context. Multicentric networks operating nationally and internationally are key in implementing precision oncology in clinical practice and support developing and improving the ecosystem and framework needed to turn invocation into benefits for patients. The review provides an overview of the diagnostic tools, innovative clinical studies, and collaborative efforts needed to realize precision cancer medicine.

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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
clinical trials, molecular diagnostics, personalized oncology, precision cancer medicine, precision medicine networks
in
Journal of Internal Medicine
volume
294
issue
4
pages
27 pages
publisher
Wiley-Blackwell
external identifiers
  • scopus:85169046024
  • pmid:37641393
ISSN
0954-6820
DOI
10.1111/joim.13709
language
English
LU publication?
yes
id
e7e33448-7a4b-4184-be92-1fd46b55db90
date added to LUP
2023-11-10 13:06:30
date last changed
2024-02-05 21:20:02
@article{e7e33448-7a4b-4184-be92-1fd46b55db90,
  abstract     = {{<p>Precision cancer medicine is a multidisciplinary team effort that requires involvement and commitment of many stakeholders including the society at large. Building on the success of significant advances in precision therapy for oncological patients over the last two decades, future developments will be significantly shaped by improvements in scalable molecular diagnostics in which increasingly complex multilayered datasets require transformation into clinically useful information guiding patient management at fast turnaround times. Adaptive profiling strategies involving tissue- and liquid-based testing that account for the immense plasticity of cancer during the patient's journey and also include early detection approaches are already finding their way into clinical routine and will become paramount. A second major driver is the development of smart clinical trials and trial concepts which, complemented by real-world evidence, rapidly broaden the spectrum of therapeutic options. Tight coordination with regulatory agencies and health technology assessment bodies is crucial in this context. Multicentric networks operating nationally and internationally are key in implementing precision oncology in clinical practice and support developing and improving the ecosystem and framework needed to turn invocation into benefits for patients. The review provides an overview of the diagnostic tools, innovative clinical studies, and collaborative efforts needed to realize precision cancer medicine.</p>}},
  author       = {{Edsjö, Anders and Holmquist, Louise and Geoerger, Birgit and Nowak, Frédérique and Gomon, Georgy and Alix-Panabières, Catherine and Ploeger, Carolin and Lassen, Ulrik and Le Tourneau, Christophe and Lehtiö, Janne and Ott, Patrick A. and von Deimling, Andreas and Fröhling, Stefan and Voest, Emile and Klauschen, Frederick and Dienstmann, Rodrigo and Alshibany, Aisha and Siu, Lillian L. and Stenzinger, Albrecht}},
  issn         = {{0954-6820}},
  keywords     = {{clinical trials; molecular diagnostics; personalized oncology; precision cancer medicine; precision medicine networks}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{455--481}},
  publisher    = {{Wiley-Blackwell}},
  series       = {{Journal of Internal Medicine}},
  title        = {{Precision cancer medicine : Concepts, current practice, and future developments}},
  url          = {{http://dx.doi.org/10.1111/joim.13709}},
  doi          = {{10.1111/joim.13709}},
  volume       = {{294}},
  year         = {{2023}},
}