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Prevalence of sexually transmitted infections (HIV, hepatitis B virus, herpes simplex virus type 2, and syphilis) in pregnant women in Ethiopia : Trends over 10 years (2005-2014)

Kassa, Desta; Gebremichael, Gebremedhin; Tilahun, Tesfaye; Ayalkebet, Abenezer; Abrha, Yemane; Mesfin, Getnet; Belay, Yohannes; Demissie, Minilik LU ; Gebrexiabher, Atsbeha and Assefa, Yibeltal (2019) In International Journal of Infectious Diseases 79. p.50-57
Abstract

OBJECTIVES: This study was performed to determine the trends in seroprevalence of four major sexually transmitted infections (STIs) (HIV, hepatitis B virus (HBV), herpes simplex virus type 2 (HSV-2), and syphilis) over a 10-year period (2005-2014) in pregnant women in Ethiopia.

METHODS: Pregnant women (15-49 years old) who were enrolled in the antenatal care-based national HIV surveillance were included. Serological tests for HIV, HBV, HSV-2, and syphilis were done on serum/plasma samples.

RESULTS: A total of 4887 pregnant women were included. Results showed a decline in prevalence of these STIs by 40-60% over the 10 years (2005-2014): HIV (10.5% to 5.5%), syphilis (2.5% to 1.1%), HBV (12.6% to 6.7%), and HSV-2 (47.5% to... (More)

OBJECTIVES: This study was performed to determine the trends in seroprevalence of four major sexually transmitted infections (STIs) (HIV, hepatitis B virus (HBV), herpes simplex virus type 2 (HSV-2), and syphilis) over a 10-year period (2005-2014) in pregnant women in Ethiopia.

METHODS: Pregnant women (15-49 years old) who were enrolled in the antenatal care-based national HIV surveillance were included. Serological tests for HIV, HBV, HSV-2, and syphilis were done on serum/plasma samples.

RESULTS: A total of 4887 pregnant women were included. Results showed a decline in prevalence of these STIs by 40-60% over the 10 years (2005-2014): HIV (10.5% to 5.5%), syphilis (2.5% to 1.1%), HBV (12.6% to 6.7%), and HSV-2 (47.5% to 28.5%). In 2014, 109/4887 (2.2%) women had triple infections. In 2005, 2007, and 2009, the prevalence of HSV-2 in the older age group (35-45 years) (47.1%, 47.4%, and 50.0%, respectively) was higher than that in the younger age group (15-24 years) (40.9%, 19.5%, and 20.2%, respectively). Age category (Chi-square=22.4, p<0.001), study sites/residence (Chi-square=135.2, p=0.001), and time/years (Chi-square=58.9, p=0.001) were associated with a positive HSV-2 test result.

CONCLUSIONS: A decline in HIV, HBV, HSV-2, and syphilis of >40% was seen over the years in Ethiopia. However, an intermediate endemicity level of HBV and higher prevalence of HIV and HSV-2 by 2014, suggest the need to strengthen prevention strategy for STIs.

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keywords
Adolescent, Adult, Ethiopia/epidemiology, Female, HIV Infections/epidemiology, Hepatitis B/epidemiology, Herpes Genitalis/epidemiology, Herpesvirus 2, Human, Humans, Middle Aged, Pregnancy, Pregnancy Complications, Infectious/epidemiology, Prevalence, Seroepidemiologic Studies, Sexually Transmitted Diseases, Viral/epidemiology, Syphilis/epidemiology, Young Adult
in
International Journal of Infectious Diseases
volume
79
pages
50 - 57
publisher
Elsevier
external identifiers
  • scopus:85058210180
ISSN
1878-3511
DOI
10.1016/j.ijid.2018.11.009
language
English
LU publication?
no
id
e7eea196-1b57-4ae9-86ed-271c1c78cad8
date added to LUP
2019-09-12 09:54:30
date last changed
2019-09-15 05:21:48
@article{e7eea196-1b57-4ae9-86ed-271c1c78cad8,
  abstract     = {<p>OBJECTIVES: This study was performed to determine the trends in seroprevalence of four major sexually transmitted infections (STIs) (HIV, hepatitis B virus (HBV), herpes simplex virus type 2 (HSV-2), and syphilis) over a 10-year period (2005-2014) in pregnant women in Ethiopia.</p><p>METHODS: Pregnant women (15-49 years old) who were enrolled in the antenatal care-based national HIV surveillance were included. Serological tests for HIV, HBV, HSV-2, and syphilis were done on serum/plasma samples.</p><p>RESULTS: A total of 4887 pregnant women were included. Results showed a decline in prevalence of these STIs by 40-60% over the 10 years (2005-2014): HIV (10.5% to 5.5%), syphilis (2.5% to 1.1%), HBV (12.6% to 6.7%), and HSV-2 (47.5% to 28.5%). In 2014, 109/4887 (2.2%) women had triple infections. In 2005, 2007, and 2009, the prevalence of HSV-2 in the older age group (35-45 years) (47.1%, 47.4%, and 50.0%, respectively) was higher than that in the younger age group (15-24 years) (40.9%, 19.5%, and 20.2%, respectively). Age category (Chi-square=22.4, p&lt;0.001), study sites/residence (Chi-square=135.2, p=0.001), and time/years (Chi-square=58.9, p=0.001) were associated with a positive HSV-2 test result.</p><p>CONCLUSIONS: A decline in HIV, HBV, HSV-2, and syphilis of &gt;40% was seen over the years in Ethiopia. However, an intermediate endemicity level of HBV and higher prevalence of HIV and HSV-2 by 2014, suggest the need to strengthen prevention strategy for STIs.</p>},
  author       = {Kassa, Desta and Gebremichael, Gebremedhin and Tilahun, Tesfaye and Ayalkebet, Abenezer and Abrha, Yemane and Mesfin, Getnet and Belay, Yohannes and Demissie, Minilik and Gebrexiabher, Atsbeha and Assefa, Yibeltal},
  issn         = {1878-3511},
  keyword      = {Adolescent,Adult,Ethiopia/epidemiology,Female,HIV Infections/epidemiology,Hepatitis B/epidemiology,Herpes Genitalis/epidemiology,Herpesvirus 2, Human,Humans,Middle Aged,Pregnancy,Pregnancy Complications, Infectious/epidemiology,Prevalence,Seroepidemiologic Studies,Sexually Transmitted Diseases, Viral/epidemiology,Syphilis/epidemiology,Young Adult},
  language     = {eng},
  pages        = {50--57},
  publisher    = {Elsevier},
  series       = {International Journal of Infectious Diseases},
  title        = {Prevalence of sexually transmitted infections (HIV, hepatitis B virus, herpes simplex virus type 2, and syphilis) in pregnant women in Ethiopia : Trends over 10 years (2005-2014)},
  url          = {http://dx.doi.org/10.1016/j.ijid.2018.11.009},
  volume       = {79},
  year         = {2019},
}