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Gelatin cryogels crosslinked with oxidized dextran and containing freshly formed hydroxyapatite as potential bone tissue-engineering scaffolds

Inci, Ilyas ; Kirsebom, Harald LU ; Galaev, Igor LU ; Mattiasson, Bo LU and Piskin, Erhan (2013) In Journal of Tissue Engineering and Regenerative Medicine 7(7). p.584-588
Abstract
Gelatin-based cryogels were prepared by using a novel crosslinker, oxidized dextran, which was synthesized and used in the study. The cryogels were also loaded with freshly formed hydroxyapatite (HA) particles. These cryogels are opaque, spongy and highly elastic and have a pore structure with large interconnected pores. They swell about 500% in aqueous media and within a few minutes reach their final swollen forms. The elastic moduli of HA-containing cryogels were 18.5 +/- 3.0 kPa, which is suitable for non-load-bearing bone tissue-engineering (TE) applications, especially for the craniofacial area. Copyright (c) 2012 John Wiley & Sons, Ltd.
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author
; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
cryogelation, cryogel, scaffold, bone tissue engineering, gelatin, hydroxyapatite, oxidized dextran as crosslinker
in
Journal of Tissue Engineering and Regenerative Medicine
volume
7
issue
7
pages
584 - 588
publisher
John Wiley & Sons Inc.
external identifiers
  • wos:000320728400008
  • scopus:84879550478
  • pmid:22733656
ISSN
1932-6254
DOI
10.1002/term.1464
language
English
LU publication?
yes
id
e831bbce-79ef-4608-9b99-08279f7bccc5 (old id 3987267)
date added to LUP
2016-04-01 09:56:35
date last changed
2022-02-24 20:47:01
@article{e831bbce-79ef-4608-9b99-08279f7bccc5,
  abstract     = {{Gelatin-based cryogels were prepared by using a novel crosslinker, oxidized dextran, which was synthesized and used in the study. The cryogels were also loaded with freshly formed hydroxyapatite (HA) particles. These cryogels are opaque, spongy and highly elastic and have a pore structure with large interconnected pores. They swell about 500% in aqueous media and within a few minutes reach their final swollen forms. The elastic moduli of HA-containing cryogels were 18.5 +/- 3.0 kPa, which is suitable for non-load-bearing bone tissue-engineering (TE) applications, especially for the craniofacial area. Copyright (c) 2012 John Wiley & Sons, Ltd.}},
  author       = {{Inci, Ilyas and Kirsebom, Harald and Galaev, Igor and Mattiasson, Bo and Piskin, Erhan}},
  issn         = {{1932-6254}},
  keywords     = {{cryogelation; cryogel; scaffold; bone tissue engineering; gelatin; hydroxyapatite; oxidized dextran as crosslinker}},
  language     = {{eng}},
  number       = {{7}},
  pages        = {{584--588}},
  publisher    = {{John Wiley & Sons Inc.}},
  series       = {{Journal of Tissue Engineering and Regenerative Medicine}},
  title        = {{Gelatin cryogels crosslinked with oxidized dextran and containing freshly formed hydroxyapatite as potential bone tissue-engineering scaffolds}},
  url          = {{http://dx.doi.org/10.1002/term.1464}},
  doi          = {{10.1002/term.1464}},
  volume       = {{7}},
  year         = {{2013}},
}