Normal weight promotes remission and low number of islet antibodies prolong the duration of remission in Type 1 diabetes
(2004) In Diabetic Medicine 21(5). p.447-455- Abstract
- Aim To identify clinical, immunological and biochemical factors that predict remission, and its duration in a large cohort of young adults with Type 1 diabetes mellitus (DM). Methods In Sweden 362 patients (15-34 years) classified as Type 1 DM were,, included in a prospective, nation-wide population-based study. All patients were followed at local hospitals for examination of HbA(1c) and insulin dosage over a median period after diagnosis of 5 years. Duration of remission defined, as an insulin maintenance dose less than or equal to 0.3 U/kg/24 h and HbA(1c) within the normal range, was analysed in relation to characteristics at diagnosis. Results Remissions were seen in 43% of the patients with a median duration of 8 months (range 1-73).... (More)
- Aim To identify clinical, immunological and biochemical factors that predict remission, and its duration in a large cohort of young adults with Type 1 diabetes mellitus (DM). Methods In Sweden 362 patients (15-34 years) classified as Type 1 DM were,, included in a prospective, nation-wide population-based study. All patients were followed at local hospitals for examination of HbA(1c) and insulin dosage over a median period after diagnosis of 5 years. Duration of remission defined, as an insulin maintenance dose less than or equal to 0.3 U/kg/24 h and HbA(1c) within the normal range, was analysed in relation to characteristics at diagnosis. Results Remissions were seen in 43% of the patients with a median duration of 8 months (range 1-73). Sixteen per cent had a remission with a duration > 12 months. Among patients with antibodies (ab(+)), bivariate analysis suggested that adult age, absence of low BMI, high plasma C-peptide concentrations, lack of ketonuria or ketoacidosis at diagnosis and low insulin dose at discharge from hospital were associated with a high possibility of achieving remission. Multiple regression showed that normal weight (BMI of 20-24.9 kg/m(2)) was the only factor that remained significant for the possibility of entering remission. In survival analysis among ab(+) remitters, a low number of islet antibodies, one or two instead of three or four, were associated with a long duration of remissions. Conclusion In islet antibody-positive Type 1 DM, normal body weight was the strongest factor for entering remission, whilst a low number of islet antibodies was of importance for the duration. (Less)
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https://lup.lub.lu.se/record/279885
- author
- organization
- publishing date
- 2004
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Type 1 DM, remission, BMI, islet antibodies, young adults
- in
- Diabetic Medicine
- volume
- 21
- issue
- 5
- pages
- 447 - 455
- publisher
- Wiley-Blackwell
- external identifiers
-
- wos:000221243700007
- scopus:2342482358
- ISSN
- 1464-5491
- DOI
- 10.1111/j.1464-5491.2004.01175.x
- language
- English
- LU publication?
- yes
- id
- e862edb3-327a-4e12-bbe0-4eac4d14f0aa (old id 279885)
- date added to LUP
- 2016-04-01 16:34:44
- date last changed
- 2024-01-11 10:22:03
@article{e862edb3-327a-4e12-bbe0-4eac4d14f0aa,
abstract = {{Aim To identify clinical, immunological and biochemical factors that predict remission, and its duration in a large cohort of young adults with Type 1 diabetes mellitus (DM). Methods In Sweden 362 patients (15-34 years) classified as Type 1 DM were,, included in a prospective, nation-wide population-based study. All patients were followed at local hospitals for examination of HbA(1c) and insulin dosage over a median period after diagnosis of 5 years. Duration of remission defined, as an insulin maintenance dose less than or equal to 0.3 U/kg/24 h and HbA(1c) within the normal range, was analysed in relation to characteristics at diagnosis. Results Remissions were seen in 43% of the patients with a median duration of 8 months (range 1-73). Sixteen per cent had a remission with a duration > 12 months. Among patients with antibodies (ab(+)), bivariate analysis suggested that adult age, absence of low BMI, high plasma C-peptide concentrations, lack of ketonuria or ketoacidosis at diagnosis and low insulin dose at discharge from hospital were associated with a high possibility of achieving remission. Multiple regression showed that normal weight (BMI of 20-24.9 kg/m(2)) was the only factor that remained significant for the possibility of entering remission. In survival analysis among ab(+) remitters, a low number of islet antibodies, one or two instead of three or four, were associated with a long duration of remissions. Conclusion In islet antibody-positive Type 1 DM, normal body weight was the strongest factor for entering remission, whilst a low number of islet antibodies was of importance for the duration.}},
author = {{Scholin, A and Törn, Carina and Nystrom, L and Berne, C and Arnqvist, H and Blohme, G and Bolinder, J and Eriksson, JW and Kockum, I and Landin-Olsson, Mona and Ostman, J and Karlsson, FA and Sundkvist, Göran and Bjork, E}},
issn = {{1464-5491}},
keywords = {{Type 1 DM; remission; BMI; islet antibodies; young adults}},
language = {{eng}},
number = {{5}},
pages = {{447--455}},
publisher = {{Wiley-Blackwell}},
series = {{Diabetic Medicine}},
title = {{Normal weight promotes remission and low number of islet antibodies prolong the duration of remission in Type 1 diabetes}},
url = {{http://dx.doi.org/10.1111/j.1464-5491.2004.01175.x}},
doi = {{10.1111/j.1464-5491.2004.01175.x}},
volume = {{21}},
year = {{2004}},
}