Characterization of Changes in P-Wave VCG Loops Following Pulmonary-Vein Isolation
(2021) In Sensors 21(5).- Abstract
- Atrial fibrillation is the most common type of cardiac arrhythmia in clinical practice. Currently, catheter ablation for pulmonary-vein isolation is a well-established treatment for maintaining sinus rhythm when antiarrhythmic drugs do not succeed. Unfortunately, arrhythmia recurrence after catheter ablation remains common, with estimated rates of up to 45%. A better understanding of factors leading to atrial-fibrillation recurrence is needed. Hence, the aim of this study is to characterize changes in the atrial propagation pattern following pulmonary-vein isolation, and investigate the relation between such characteristics and atrial-fibrillation recurrence. Fifty patients with paroxysmal atrial fibrillation who had undergone catheter... (More)
- Atrial fibrillation is the most common type of cardiac arrhythmia in clinical practice. Currently, catheter ablation for pulmonary-vein isolation is a well-established treatment for maintaining sinus rhythm when antiarrhythmic drugs do not succeed. Unfortunately, arrhythmia recurrence after catheter ablation remains common, with estimated rates of up to 45%. A better understanding of factors leading to atrial-fibrillation recurrence is needed. Hence, the aim of this study is to characterize changes in the atrial propagation pattern following pulmonary-vein isolation, and investigate the relation between such characteristics and atrial-fibrillation recurrence. Fifty patients with paroxysmal atrial fibrillation who had undergone catheter ablation were included in this study. Time-segment and vectorcardiogram-loop-morphology analyses were applied to characterize P waves extracted from 1 min long 12-lead electrocardiogram segments before and after the procedure, respectively. Results showed that P-wave vectorcardiogram loops were significantly less round and more planar, P waves and PR intervals were significantly shorter, and heart rate was significantly higher after the procedure. Differences were larger for patients who did not have arrhythmia recurrences at 2 years of follow-up; for these patients, the pre- and postprocedure P waves could be identified with 84% accuracy. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/e8755288-c10b-4f4a-a12e-ccf76465200f
- author
- Ortigosa, Nuria ; Cano, Óscar and Sandberg, Frida LU
- organization
- publishing date
- 2021-03-09
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- vectorcardiogram (VCG), atrial fibrillation, P wave, pulmonary-vein isolation
- in
- Sensors
- volume
- 21
- issue
- 5
- article number
- 1923
- publisher
- MDPI AG
- external identifiers
-
- scopus:85102112338
- pmid:33803483
- ISSN
- 1424-8220
- DOI
- 10.3390/s21051923
- project
- Diagnostic Biomarkers in Atrial Fibrillation - Autonomic Nervous System Response as a Sign of Disease Progression
- language
- English
- LU publication?
- yes
- id
- e8755288-c10b-4f4a-a12e-ccf76465200f
- date added to LUP
- 2021-03-10 08:39:39
- date last changed
- 2022-04-27 00:43:19
@article{e8755288-c10b-4f4a-a12e-ccf76465200f,
abstract = {{Atrial fibrillation is the most common type of cardiac arrhythmia in clinical practice. Currently, catheter ablation for pulmonary-vein isolation is a well-established treatment for maintaining sinus rhythm when antiarrhythmic drugs do not succeed. Unfortunately, arrhythmia recurrence after catheter ablation remains common, with estimated rates of up to 45%. A better understanding of factors leading to atrial-fibrillation recurrence is needed. Hence, the aim of this study is to characterize changes in the atrial propagation pattern following pulmonary-vein isolation, and investigate the relation between such characteristics and atrial-fibrillation recurrence. Fifty patients with paroxysmal atrial fibrillation who had undergone catheter ablation were included in this study. Time-segment and vectorcardiogram-loop-morphology analyses were applied to characterize P waves extracted from 1 min long 12-lead electrocardiogram segments before and after the procedure, respectively. Results showed that P-wave vectorcardiogram loops were significantly less round and more planar, P waves and PR intervals were significantly shorter, and heart rate was significantly higher after the procedure. Differences were larger for patients who did not have arrhythmia recurrences at 2 years of follow-up; for these patients, the pre- and postprocedure P waves could be identified with 84% accuracy.}},
author = {{Ortigosa, Nuria and Cano, Óscar and Sandberg, Frida}},
issn = {{1424-8220}},
keywords = {{vectorcardiogram (VCG); atrial fibrillation; P wave; pulmonary-vein isolation}},
language = {{eng}},
month = {{03}},
number = {{5}},
publisher = {{MDPI AG}},
series = {{Sensors}},
title = {{Characterization of Changes in P-Wave VCG Loops Following Pulmonary-Vein Isolation}},
url = {{http://dx.doi.org/10.3390/s21051923}},
doi = {{10.3390/s21051923}},
volume = {{21}},
year = {{2021}},
}