Lowering the dose of antenatal steroids: The effects of a single course of betamethasone on somatic growth and brain cell proliferation in the rat
Bruschettini, Matteo LU
; van den Hove, DLA
; Gazzolo, D
; Steinbusch, HWM
and Blanco, CE
(2006)
In American Journal of Obstetrics and Gynecology
194(5).
p.1341-1346
- Abstract
- We investigated the effects of a single course of antenatal betamethasone on neonatal somatic and brain development. On day 20 of gestation, pregnant rats were injected with either with 170 mu g kg(-1) body weight of betamethasone ("clinically-equivalent dose," equivalent to 12 mg twice, 24 hours apart) or half this dose or vehicle. Pups (8-11 animals per experimental group per time-point per gender) were analyzed at 1 (P1), 2, and 21 days after birth. We report that betamethasone induced a significant dose-dependent decrease of somatic measurements in both genders. At PI cell proliferation was affected by the "clinically equivalent dose" only in the subventricular zone in both genders and in the hippocampus in males. In summary, we show... (More)
- We investigated the effects of a single course of antenatal betamethasone on neonatal somatic and brain development. On day 20 of gestation, pregnant rats were injected with either with 170 mu g kg(-1) body weight of betamethasone ("clinically-equivalent dose," equivalent to 12 mg twice, 24 hours apart) or half this dose or vehicle. Pups (8-11 animals per experimental group per time-point per gender) were analyzed at 1 (P1), 2, and 21 days after birth. We report that betamethasone induced a significant dose-dependent decrease of somatic measurements in both genders. At PI cell proliferation was affected by the "clinically equivalent dose" only in the subventricular zone in both genders and in the hippocampus in males. In summary, we show for the first time that a lower dose (equivalent to 6 mg) induces fewer and less severe effects on somatic growth, whereas it does not affect cell proliferation within the brain. (c) 2006 Mosby, Inc. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/7856202
- author
- Bruschettini, Matteo
LU
; van den Hove, DLA
; Gazzolo, D
; Steinbusch, HWM
and Blanco, CE
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- pregnancy, prenatal corticosteroids, glucocorticoids, neuroeenesis, Fisher 344 rat
- in
- American Journal of Obstetrics and Gynecology
- volume
- 194
- issue
- 5
- pages
- 1341 - 1346
- publisher
- Elsevier
- external identifiers
-
- wos:000237331900024
- scopus:33646116302
- pmid:16579916
- ISSN
- 1097-6868
- DOI
- 10.1016/j.ajog.2005.11.044
- language
- English
- LU publication?
- no
- id
- e8949203-28bb-4538-8163-c7b8000436e2 (old id 7856202)
- date added to LUP
- 2016-04-01 12:22:07
- date last changed
- 2022-02-03 21:12:34
@article{e8949203-28bb-4538-8163-c7b8000436e2,
abstract = {{We investigated the effects of a single course of antenatal betamethasone on neonatal somatic and brain development. On day 20 of gestation, pregnant rats were injected with either with 170 mu g kg(-1) body weight of betamethasone ("clinically-equivalent dose," equivalent to 12 mg twice, 24 hours apart) or half this dose or vehicle. Pups (8-11 animals per experimental group per time-point per gender) were analyzed at 1 (P1), 2, and 21 days after birth. We report that betamethasone induced a significant dose-dependent decrease of somatic measurements in both genders. At PI cell proliferation was affected by the "clinically equivalent dose" only in the subventricular zone in both genders and in the hippocampus in males. In summary, we show for the first time that a lower dose (equivalent to 6 mg) induces fewer and less severe effects on somatic growth, whereas it does not affect cell proliferation within the brain. (c) 2006 Mosby, Inc. All rights reserved.}},
author = {{Bruschettini, Matteo and van den Hove, DLA and Gazzolo, D and Steinbusch, HWM and Blanco, CE}},
issn = {{1097-6868}},
keywords = {{pregnancy; prenatal corticosteroids; glucocorticoids; neuroeenesis; Fisher 344 rat}},
language = {{eng}},
number = {{5}},
pages = {{1341--1346}},
publisher = {{Elsevier}},
series = {{American Journal of Obstetrics and Gynecology}},
title = {{Lowering the dose of antenatal steroids: The effects of a single course of betamethasone on somatic growth and brain cell proliferation in the rat}},
url = {{http://dx.doi.org/10.1016/j.ajog.2005.11.044}},
doi = {{10.1016/j.ajog.2005.11.044}},
volume = {{194}},
year = {{2006}},
}