Embryo-derive TNF promotes decidualization via fibroblast activation
(2023) In eLife 12.- Abstract
Decidualization is a process in which endometrial stromal fibroblasts differentiate into specialized secretory decidual cells and essential for the successful establishment of pregnancy. The underlying mechanism during decidualization still remains poorly defined. Because decidualization and fibroblast activation share similar characteristics, this study was to examine whether fibroblast activation is involved in decidualization. In our study, fibroblast activation-related markers are obvi-ously detected in pregnant decidua and under in vitro decidualization. ACTIVIN A secreted under fibroblast activation promotes in vitro decidualization. We showed that arachidonic acid released from uterine luminal epithelium can induce fibroblast... (More)
Decidualization is a process in which endometrial stromal fibroblasts differentiate into specialized secretory decidual cells and essential for the successful establishment of pregnancy. The underlying mechanism during decidualization still remains poorly defined. Because decidualization and fibroblast activation share similar characteristics, this study was to examine whether fibroblast activation is involved in decidualization. In our study, fibroblast activation-related markers are obvi-ously detected in pregnant decidua and under in vitro decidualization. ACTIVIN A secreted under fibroblast activation promotes in vitro decidualization. We showed that arachidonic acid released from uterine luminal epithelium can induce fibroblast activation and decidualization through PGI2 and its nuclear receptor PPARδ. Based on the significant difference of fibroblast activation-related markers between pregnant and pseudopregnant mice, we found that embryo-derived TNF promotes CPLA2α phosphorylation and arachidonic acid release from luminal epithelium. Fibroblast activation is also detected under human in vitro decidualization. Similar arachidonic acid-PGI2-PPARδ-ACTIVIN A pathway is conserved in human endometrium. Collectively, our data indicate that embryo-derived TNF promotes CPLA2α phosphorylation and arachidonic acid release from luminal epithelium to induce fibroblast activation and decidualization.
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- author
- Chen, Si Ting ; Shi, Wen Wen ; Lin, Yu Qian ; Yang, Zhen Shan LU ; Wang, Ying ; Li, Meng Yuan ; Li, Yue ; Liu, Ai Xia ; Hu, Yali and Yang, Zeng Ming
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- in
- eLife
- volume
- 12
- article number
- e82970
- pages
- 26 pages
- publisher
- eLife Sciences Publications
- external identifiers
-
- pmid:37458359
- scopus:85166362506
- ISSN
- 2050-084X
- DOI
- 10.7554/eLife.82970
- language
- English
- LU publication?
- no
- additional info
- Funding Information: National Key Research and 2018YFC1004400 Development Program of China Funding Information: Funding This study was supported by National Natural Science Foundation of China (32171114 and 31871511) and National Key Research and Development Program of China (2018YFC1004400). Funding Information: National Natural Science Foundation of China Publisher Copyright: © 2023, eLife Sciences Publications Ltd. All rights reserved.
- id
- e8a050e0-e387-42a7-bc10-1bd357abd2a2
- date added to LUP
- 2024-02-28 15:09:18
- date last changed
- 2024-04-13 11:48:24
@article{e8a050e0-e387-42a7-bc10-1bd357abd2a2, abstract = {{<p>Decidualization is a process in which endometrial stromal fibroblasts differentiate into specialized secretory decidual cells and essential for the successful establishment of pregnancy. The underlying mechanism during decidualization still remains poorly defined. Because decidualization and fibroblast activation share similar characteristics, this study was to examine whether fibroblast activation is involved in decidualization. In our study, fibroblast activation-related markers are obvi-ously detected in pregnant decidua and under in vitro decidualization. ACTIVIN A secreted under fibroblast activation promotes in vitro decidualization. We showed that arachidonic acid released from uterine luminal epithelium can induce fibroblast activation and decidualization through PGI<sub>2</sub> and its nuclear receptor PPARδ. Based on the significant difference of fibroblast activation-related markers between pregnant and pseudopregnant mice, we found that embryo-derived TNF promotes CPLA<sub>2α</sub> phosphorylation and arachidonic acid release from luminal epithelium. Fibroblast activation is also detected under human in vitro decidualization. Similar arachidonic acid-PGI<sub>2</sub>-PPARδ-ACTIVIN A pathway is conserved in human endometrium. Collectively, our data indicate that embryo-derived TNF promotes CPLA<sub>2α</sub> phosphorylation and arachidonic acid release from luminal epithelium to induce fibroblast activation and decidualization.</p>}}, author = {{Chen, Si Ting and Shi, Wen Wen and Lin, Yu Qian and Yang, Zhen Shan and Wang, Ying and Li, Meng Yuan and Li, Yue and Liu, Ai Xia and Hu, Yali and Yang, Zeng Ming}}, issn = {{2050-084X}}, language = {{eng}}, publisher = {{eLife Sciences Publications}}, series = {{eLife}}, title = {{Embryo-derive TNF promotes decidualization via fibroblast activation}}, url = {{http://dx.doi.org/10.7554/eLife.82970}}, doi = {{10.7554/eLife.82970}}, volume = {{12}}, year = {{2023}}, }