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Spectral edge frequency during general anaesthesia: A narrative literature review

Jildenstål, Pether LU ; Bäckström, Amanda ; Hedman, Klara and Warrén Stomberg, Margareta (2022) In Journal of International Medical Research 50(8). p.1-12
Abstract
Previous studies have attempted to determine the depth of anaesthesia with different anaesthetic agents using electroencephalogram (EEG) measurements with variable success. Measuring depth of anaesthesia is confounded by the complexity of the EEG and the fact that different agents create different pattens. A narrative review was undertaken to examine the available research evidence on the effect and reliability of spectral edge frequency (SEF) for assessing the depth of anaesthesia in adult patients under general anaesthesia. A systematic search of the PubMed®, Scopus®, CINAHL and Cochrane databases identified six randomized controlled trials and five observational studies. The findings of these studies suggest that SEF varies according to... (More)
Previous studies have attempted to determine the depth of anaesthesia with different anaesthetic agents using electroencephalogram (EEG) measurements with variable success. Measuring depth of anaesthesia is confounded by the complexity of the EEG and the fact that different agents create different pattens. A narrative review was undertaken to examine the available research evidence on the effect and reliability of spectral edge frequency (SEF) for assessing the depth of anaesthesia in adult patients under general anaesthesia. A systematic search of the PubMed®, Scopus®, CINAHL and Cochrane databases identified six randomized controlled trials and five observational studies. The findings of these studies suggest that SEF varies according to the anaesthetic drugs used. Remifentanil and age are two factors that can affect SEF, while other opioids and benzodiazepine (administered separately) seem to have no effect. No patients experienced intraoperative awareness. However, this does not indicate that SEF can provide full protection against it and the number of articles in which intraoperative awareness was studied was too small to afford any certainty. None of the studies demonstrated a reliable SEF interval associated with adequate general anaesthesia. SEF must be adapted to the anaesthetic drug used, the patient’s age and state while under general anaesthesia. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of International Medical Research
volume
50
issue
8
pages
1 - 12
publisher
SAGE Publications
external identifiers
  • pmid:35971317
  • scopus:85136001218
ISSN
1473-2300
DOI
10.1177/03000605221118682
language
English
LU publication?
yes
id
e8b7bef3-15ee-4e38-92c1-6081c4fa6077
date added to LUP
2022-08-30 20:00:54
date last changed
2022-09-19 13:27:28
@article{e8b7bef3-15ee-4e38-92c1-6081c4fa6077,
  abstract     = {{Previous studies have attempted to determine the depth of anaesthesia with different anaesthetic agents using electroencephalogram (EEG) measurements with variable success. Measuring depth of anaesthesia is confounded by the complexity of the EEG and the fact that different agents create different pattens. A narrative review was undertaken to examine the available research evidence on the effect and reliability of spectral edge frequency (SEF) for assessing the depth of anaesthesia in adult patients under general anaesthesia. A systematic search of the PubMed®, Scopus®, CINAHL and Cochrane databases identified six randomized controlled trials and five observational studies. The findings of these studies suggest that SEF varies according to the anaesthetic drugs used. Remifentanil and age are two factors that can affect SEF, while other opioids and benzodiazepine (administered separately) seem to have no effect. No patients experienced intraoperative awareness. However, this does not indicate that SEF can provide full protection against it and the number of articles in which intraoperative awareness was studied was too small to afford any certainty. None of the studies demonstrated a reliable SEF interval associated with adequate general anaesthesia. SEF must be adapted to the anaesthetic drug used, the patient’s age and state while under general anaesthesia.}},
  author       = {{Jildenstål, Pether and Bäckström, Amanda and Hedman, Klara and Warrén Stomberg, Margareta}},
  issn         = {{1473-2300}},
  language     = {{eng}},
  month        = {{08}},
  number       = {{8}},
  pages        = {{1--12}},
  publisher    = {{SAGE Publications}},
  series       = {{Journal of International Medical Research}},
  title        = {{Spectral edge frequency during general anaesthesia: A narrative literature review}},
  url          = {{https://lup.lub.lu.se/search/files/123325136/Spectral_edge_frequency_during_general_anaesthesia_A_narrative_literature_review.pdf}},
  doi          = {{10.1177/03000605221118682}},
  volume       = {{50}},
  year         = {{2022}},
}