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The epidemiological trend of acute promyelocytic leukemia over past four decades : a population-based analysis

Chen, Ziren ; Mai, Wei ; Li, Zhengxiong ; Zhang, Haoyang LU orcid ; Zheng, Yu ; Hong, Shunrong ; Yang, Wencong ; Xiao, Weiliang ; Chen, Zhilin and Wang, Shuncong (2019) In Leukemia and Lymphoma 60(14). p.3470-3481
Abstract

The treatment regimens for acute promyelocytic leukemia (APL) dramatically changed over time. However, its survival trend, based on a large sample size has not been reported. Patients diagnosed with APL were accessed from the Surveillance, Epidemiology, and End Results database. Their incidence and survival trend were evaluated in overall and subgroup levels. The overall incidence of APL increased with an annual percentage change of 5.5% from 1992 to 2006 and remained stable thereafter. In addition, the 5-year relative survival rates of APL improved significantly, from 12.3 to 32.2% to 59.5 to 72.1% over past four decades (p <.0001), sharing similar trend with different subgroups. Importantly, survival disparities exist among races... (More)

The treatment regimens for acute promyelocytic leukemia (APL) dramatically changed over time. However, its survival trend, based on a large sample size has not been reported. Patients diagnosed with APL were accessed from the Surveillance, Epidemiology, and End Results database. Their incidence and survival trend were evaluated in overall and subgroup levels. The overall incidence of APL increased with an annual percentage change of 5.5% from 1992 to 2006 and remained stable thereafter. In addition, the 5-year relative survival rates of APL improved significantly, from 12.3 to 32.2% to 59.5 to 72.1% over past four decades (p <.0001), sharing similar trend with different subgroups. Importantly, survival disparities exist among races and different socioeconomic status groups, with superior survival in whites and patients in low-poverty regions. Increasing incidence urges for increased awareness of clinicians over diagnosis of APL. In addition, a wider insurance coverage may help balance survival gap.

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author
; ; ; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
subject
keywords
granulocytes, Myeloid leukemias and dysplasias, prognostication
in
Leukemia and Lymphoma
volume
60
issue
14
pages
3470 - 3481
publisher
Taylor & Francis
external identifiers
  • pmid:31305195
  • scopus:85069055944
ISSN
1042-8194
DOI
10.1080/10428194.2019.1639164
language
English
LU publication?
no
additional info
Publisher Copyright: © 2019, © 2019 Informa UK Limited, trading as Taylor & Francis Group.
id
e8c7e5d4-c97d-4eed-91ae-094c0ba524d6
date added to LUP
2024-02-05 16:04:10
date last changed
2024-10-07 16:07:24
@article{e8c7e5d4-c97d-4eed-91ae-094c0ba524d6,
  abstract     = {{<p>The treatment regimens for acute promyelocytic leukemia (APL) dramatically changed over time. However, its survival trend, based on a large sample size has not been reported. Patients diagnosed with APL were accessed from the Surveillance, Epidemiology, and End Results database. Their incidence and survival trend were evaluated in overall and subgroup levels. The overall incidence of APL increased with an annual percentage change of 5.5% from 1992 to 2006 and remained stable thereafter. In addition, the 5-year relative survival rates of APL improved significantly, from 12.3 to 32.2% to 59.5 to 72.1% over past four decades (p &lt;.0001), sharing similar trend with different subgroups. Importantly, survival disparities exist among races and different socioeconomic status groups, with superior survival in whites and patients in low-poverty regions. Increasing incidence urges for increased awareness of clinicians over diagnosis of APL. In addition, a wider insurance coverage may help balance survival gap.</p>}},
  author       = {{Chen, Ziren and Mai, Wei and Li, Zhengxiong and Zhang, Haoyang and Zheng, Yu and Hong, Shunrong and Yang, Wencong and Xiao, Weiliang and Chen, Zhilin and Wang, Shuncong}},
  issn         = {{1042-8194}},
  keywords     = {{granulocytes; Myeloid leukemias and dysplasias; prognostication}},
  language     = {{eng}},
  month        = {{12}},
  number       = {{14}},
  pages        = {{3470--3481}},
  publisher    = {{Taylor & Francis}},
  series       = {{Leukemia and Lymphoma}},
  title        = {{The epidemiological trend of acute promyelocytic leukemia over past four decades : a population-based analysis}},
  url          = {{http://dx.doi.org/10.1080/10428194.2019.1639164}},
  doi          = {{10.1080/10428194.2019.1639164}},
  volume       = {{60}},
  year         = {{2019}},
}