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Biofuel cell based on microscale nanostructured electrodes with inductive coupling to rat brain neurons.

Andoralov, Viktor; Falk, Magnus; Suyatin, Dmitry LU ; Granmo, Marcus LU ; Sotres, Javier; Ludwig, Roland; Popov, Vladimir O; Schouenborg, Jens LU ; Blum, Zoltan and Shleev, Sergey (2013) In Scientific Reports 3(Nov 20).
Abstract
Miniature, self-contained biodevices powered by biofuel cells may enable a new generation of implantable, wireless, minimally invasive neural interfaces for neurophysiological in vivo studies and for clinical applications. Here we report on the fabrication of a direct electron transfer based glucose/oxygen enzymatic fuel cell (EFC) from genuinely three-dimensional (3D) nanostructured microscale gold electrodes, modified with suitable biocatalysts. We show that the process underlying the simple fabrication method of 3D nanostructured electrodes is based on an electrochemically driven transformation of physically deposited gold nanoparticles. We experimentally demonstrate that mediator-, cofactor-, and membrane-less EFCs do operate in... (More)
Miniature, self-contained biodevices powered by biofuel cells may enable a new generation of implantable, wireless, minimally invasive neural interfaces for neurophysiological in vivo studies and for clinical applications. Here we report on the fabrication of a direct electron transfer based glucose/oxygen enzymatic fuel cell (EFC) from genuinely three-dimensional (3D) nanostructured microscale gold electrodes, modified with suitable biocatalysts. We show that the process underlying the simple fabrication method of 3D nanostructured electrodes is based on an electrochemically driven transformation of physically deposited gold nanoparticles. We experimentally demonstrate that mediator-, cofactor-, and membrane-less EFCs do operate in cerebrospinal fluid and in the brain of a rat, producing amounts of electrical power sufficient to drive a self-contained biodevice, viz. 7 μW cm(-2) in vitro and 2 μW cm(-2) in vivo at an operating voltage of 0.4 V. Last but not least, we also demonstrate an inductive coupling between 3D nanobioelectrodes and living neurons. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Scientific Reports
volume
3
issue
Nov 20
publisher
Nature Publishing Group
external identifiers
  • wos:000327517300007
  • pmid:24253492
  • scopus:84888250095
ISSN
2045-2322
DOI
10.1038/srep03270
language
English
LU publication?
yes
id
e8d6c13b-1549-4f3c-8c04-d03e7ef17574 (old id 4179157)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/24253492?dopt=Abstract
date added to LUP
2013-12-02 21:19:45
date last changed
2019-02-20 05:21:08
@article{e8d6c13b-1549-4f3c-8c04-d03e7ef17574,
  abstract     = {Miniature, self-contained biodevices powered by biofuel cells may enable a new generation of implantable, wireless, minimally invasive neural interfaces for neurophysiological in vivo studies and for clinical applications. Here we report on the fabrication of a direct electron transfer based glucose/oxygen enzymatic fuel cell (EFC) from genuinely three-dimensional (3D) nanostructured microscale gold electrodes, modified with suitable biocatalysts. We show that the process underlying the simple fabrication method of 3D nanostructured electrodes is based on an electrochemically driven transformation of physically deposited gold nanoparticles. We experimentally demonstrate that mediator-, cofactor-, and membrane-less EFCs do operate in cerebrospinal fluid and in the brain of a rat, producing amounts of electrical power sufficient to drive a self-contained biodevice, viz. 7 μW cm(-2) in vitro and 2 μW cm(-2) in vivo at an operating voltage of 0.4 V. Last but not least, we also demonstrate an inductive coupling between 3D nanobioelectrodes and living neurons.},
  articleno    = {3270},
  author       = {Andoralov, Viktor and Falk, Magnus and Suyatin, Dmitry and Granmo, Marcus and Sotres, Javier and Ludwig, Roland and Popov, Vladimir O and Schouenborg, Jens and Blum, Zoltan and Shleev, Sergey},
  issn         = {2045-2322},
  language     = {eng},
  number       = {Nov 20},
  publisher    = {Nature Publishing Group},
  series       = {Scientific Reports},
  title        = {Biofuel cell based on microscale nanostructured electrodes with inductive coupling to rat brain neurons.},
  url          = {http://dx.doi.org/10.1038/srep03270},
  volume       = {3},
  year         = {2013},
}