Biofilm formation is associated with poor outcome in prosthetic joint infections caused by Staphylococcus lugdunensis
Hagstrand Aldman, Malin LU
; Thompson, Olof
LU
and Påhlman, Lisa I.
LU
(2023)
In Infectious Diseases
55(5).
p.328-332
- Abstract
Background: Staphylococcus lugdunensis has been described as a pathogen of increasing importance in prosthetic joint infections (PJI). Our aim was to describe the clinical presentation of PJI caused by S. lugdunensis, and to correlate the biofilm-forming ability of the bacterial isolates to clinical outcome. Method: S. lugdunensis isolates from PJI episodes during 2015–2019 were included and analysed for biofilm formation using a microtiter plate assay. Medical records from the corresponding patients were reviewed. Results: We identified 36 patients with PJI caused by S. lugdunensis during the study period. Early postoperative PJIs were most frequent (n = 20, 56%). Surgical intervention was performed in a majority of the patients (n =... (More)
Background: Staphylococcus lugdunensis has been described as a pathogen of increasing importance in prosthetic joint infections (PJI). Our aim was to describe the clinical presentation of PJI caused by S. lugdunensis, and to correlate the biofilm-forming ability of the bacterial isolates to clinical outcome. Method: S. lugdunensis isolates from PJI episodes during 2015–2019 were included and analysed for biofilm formation using a microtiter plate assay. Medical records from the corresponding patients were reviewed. Results: We identified 36 patients with PJI caused by S. lugdunensis during the study period. Early postoperative PJIs were most frequent (n = 20, 56%). Surgical intervention was performed in a majority of the patients (n = 33, 92%), and the dominating type of antibiotic treatment was a combination of rifampicin and ciprofloxacin (n = 27, 75%). The treatment success-rate was 81% (n = 29). All isolates causing PJI were able to form biofilm in vitro. Biofilm formation was significantly stronger in isolates causing relapsing vs non-relapsing PJI (mean OD550 3.1 ± 0.23 vs 1.14 ± 0.73 p =.001) and strong biofilm formation was also associated with late acute hematogenic PJI (mean OD550 1.8 ± 0.93 vs. 0.93 ± 0.81, p =.01). Conclusion: Strong biofilm production in S. lugdunensis isolates was associated with relapse in PJI.
(Less)
- author
- Hagstrand Aldman, Malin
LU
; Thompson, Olof
LU
and Påhlman, Lisa I.
LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- biofilm formation, prosthetic joint infections, staphylococcal infections, Staphylococcus lugdunensis, treatment outcome
- in
- Infectious Diseases
- volume
- 55
- issue
- 5
- pages
- 328 - 332
- publisher
- Informa Healthcare
- external identifiers
-
- scopus:85148528270
- pmid:36799228
- ISSN
- 2374-4235
- DOI
- 10.1080/23744235.2023.2180534
- language
- English
- LU publication?
- yes
- id
- e921df32-7e19-4256-b22a-e4d5ba8383e5
- date added to LUP
- 2023-03-07 13:41:56
- date last changed
- 2024-06-12 23:23:51
@article{e921df32-7e19-4256-b22a-e4d5ba8383e5,
abstract = {{<p>Background: Staphylococcus lugdunensis has been described as a pathogen of increasing importance in prosthetic joint infections (PJI). Our aim was to describe the clinical presentation of PJI caused by S. lugdunensis, and to correlate the biofilm-forming ability of the bacterial isolates to clinical outcome. Method: S. lugdunensis isolates from PJI episodes during 2015–2019 were included and analysed for biofilm formation using a microtiter plate assay. Medical records from the corresponding patients were reviewed. Results: We identified 36 patients with PJI caused by S. lugdunensis during the study period. Early postoperative PJIs were most frequent (n = 20, 56%). Surgical intervention was performed in a majority of the patients (n = 33, 92%), and the dominating type of antibiotic treatment was a combination of rifampicin and ciprofloxacin (n = 27, 75%). The treatment success-rate was 81% (n = 29). All isolates causing PJI were able to form biofilm in vitro. Biofilm formation was significantly stronger in isolates causing relapsing vs non-relapsing PJI (mean OD<sub>550</sub> 3.1 ± 0.23 vs 1.14 ± 0.73 p =.001) and strong biofilm formation was also associated with late acute hematogenic PJI (mean OD<sub>550</sub> 1.8 ± 0.93 vs. 0.93 ± 0.81, p =.01). Conclusion: Strong biofilm production in S. lugdunensis isolates was associated with relapse in PJI.</p>}},
author = {{Hagstrand Aldman, Malin and Thompson, Olof and Påhlman, Lisa I.}},
issn = {{2374-4235}},
keywords = {{biofilm formation; prosthetic joint infections; staphylococcal infections; Staphylococcus lugdunensis; treatment outcome}},
language = {{eng}},
number = {{5}},
pages = {{328--332}},
publisher = {{Informa Healthcare}},
series = {{Infectious Diseases}},
title = {{Biofilm formation is associated with poor outcome in prosthetic joint infections caused by Staphylococcus lugdunensis}},
url = {{http://dx.doi.org/10.1080/23744235.2023.2180534}},
doi = {{10.1080/23744235.2023.2180534}},
volume = {{55}},
year = {{2023}},
}