The association between meniscal body extrusion and the development/enlargement of bone marrow lesions on knee MRI in overweight and obese women
(2020) In Osteoarthritis and Cartilage Open 1(3-4).- Abstract
Objective: To determine the association between meniscal body extrusion and bone marrow lesion (BML) development/enlargement in overweight and obese women at high risk of knee osteoarthritis (OA). Design: We used baseline and 30 months follow-up data of the PROOF study, Netherlands, comprising overweight or obese women aged 50–60 years, free of clinical knee OA. All subjects (n = 395) completed a questionnaire on knee complaints and physical activity, underwent physical examination, radiography, and repeated 1.5 T MRI of both knees. Using the mid-coronal MRI slice, one observer measured tibial plateau width and meniscal body extrusion of both menisci in both knees. BMLs and meniscal damage were read using the semi-quantitative MOAKS... (More)
Objective: To determine the association between meniscal body extrusion and bone marrow lesion (BML) development/enlargement in overweight and obese women at high risk of knee osteoarthritis (OA). Design: We used baseline and 30 months follow-up data of the PROOF study, Netherlands, comprising overweight or obese women aged 50–60 years, free of clinical knee OA. All subjects (n = 395) completed a questionnaire on knee complaints and physical activity, underwent physical examination, radiography, and repeated 1.5 T MRI of both knees. Using the mid-coronal MRI slice, one observer measured tibial plateau width and meniscal body extrusion of both menisci in both knees. BMLs and meniscal damage were read using the semi-quantitative MOAKS scoring system by another observer. The association between BML development and meniscal extrusion was primarily analyzed with a random-effects logistic regression model adjusted for age, body weight, body height, physical activity, meniscus damage, knee alignment, and tibia width. In addition, we used a fixed-effect regression model for evaluation of knee-specific factors. Results: In our primary model, there was about 24% increased risk of BML incidence/enlargement per 1 mm extrusion (95% confidence interval [CI] 0.99, 1.57) for medial compartments and 69% risk increase (95% confidence interval [CI] 1.27, 2.25) for the lateral compartments. Results from the fixed-effects regression model were similar, strengthening the validity of the findings. Conclusions: Meniscal body extrusion is an important factor influencing BML development/enlargement, and thus may be a potential treatment target in knee OA development.
(Less)
- author
- Zhang, Fan LU ; Bierma-Zeinstra, Sita M. ; Oei, Edwin H.G. ; Turkiewicz, Aleksandra LU ; Englund, Martin LU and Runhaar, Jos
- organization
- publishing date
- 2020-01-01
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Bone marrow lesions, Meniscal extrusion, Overweight women
- in
- Osteoarthritis and Cartilage Open
- volume
- 1
- issue
- 3-4
- article number
- 100015
- publisher
- Elsevier
- external identifiers
-
- scopus:85162529498
- ISSN
- 2665-9131
- DOI
- 10.1016/j.ocarto.2019.100015
- language
- English
- LU publication?
- yes
- id
- e92a1cb3-5eb2-4b32-92eb-fa52a507b863
- date added to LUP
- 2023-10-18 09:49:33
- date last changed
- 2023-11-15 14:16:47
@article{e92a1cb3-5eb2-4b32-92eb-fa52a507b863, abstract = {{<p>Objective: To determine the association between meniscal body extrusion and bone marrow lesion (BML) development/enlargement in overweight and obese women at high risk of knee osteoarthritis (OA). Design: We used baseline and 30 months follow-up data of the PROOF study, Netherlands, comprising overweight or obese women aged 50–60 years, free of clinical knee OA. All subjects (n = 395) completed a questionnaire on knee complaints and physical activity, underwent physical examination, radiography, and repeated 1.5 T MRI of both knees. Using the mid-coronal MRI slice, one observer measured tibial plateau width and meniscal body extrusion of both menisci in both knees. BMLs and meniscal damage were read using the semi-quantitative MOAKS scoring system by another observer. The association between BML development and meniscal extrusion was primarily analyzed with a random-effects logistic regression model adjusted for age, body weight, body height, physical activity, meniscus damage, knee alignment, and tibia width. In addition, we used a fixed-effect regression model for evaluation of knee-specific factors. Results: In our primary model, there was about 24% increased risk of BML incidence/enlargement per 1 mm extrusion (95% confidence interval [CI] 0.99, 1.57) for medial compartments and 69% risk increase (95% confidence interval [CI] 1.27, 2.25) for the lateral compartments. Results from the fixed-effects regression model were similar, strengthening the validity of the findings. Conclusions: Meniscal body extrusion is an important factor influencing BML development/enlargement, and thus may be a potential treatment target in knee OA development.</p>}}, author = {{Zhang, Fan and Bierma-Zeinstra, Sita M. and Oei, Edwin H.G. and Turkiewicz, Aleksandra and Englund, Martin and Runhaar, Jos}}, issn = {{2665-9131}}, keywords = {{Bone marrow lesions; Meniscal extrusion; Overweight women}}, language = {{eng}}, month = {{01}}, number = {{3-4}}, publisher = {{Elsevier}}, series = {{Osteoarthritis and Cartilage Open}}, title = {{The association between meniscal body extrusion and the development/enlargement of bone marrow lesions on knee MRI in overweight and obese women}}, url = {{http://dx.doi.org/10.1016/j.ocarto.2019.100015}}, doi = {{10.1016/j.ocarto.2019.100015}}, volume = {{1}}, year = {{2020}}, }