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The association between meniscal body extrusion and the development/enlargement of bone marrow lesions on knee MRI in overweight and obese women

Zhang, Fan LU ; Bierma-Zeinstra, Sita M. ; Oei, Edwin H.G. ; Turkiewicz, Aleksandra LU ; Englund, Martin LU orcid and Runhaar, Jos (2020) In Osteoarthritis and Cartilage Open 1(3-4).
Abstract

Objective: To determine the association between meniscal body extrusion and bone marrow lesion (BML) development/enlargement in overweight and obese women at high risk of knee osteoarthritis (OA). Design: We used baseline and 30 months follow-up data of the PROOF study, Netherlands, comprising overweight or obese women aged 50–60 years, free of clinical knee OA. All subjects (n = 395) completed a questionnaire on knee complaints and physical activity, underwent physical examination, radiography, and repeated 1.5 T MRI of both knees. Using the mid-coronal MRI slice, one observer measured tibial plateau width and meniscal body extrusion of both menisci in both knees. BMLs and meniscal damage were read using the semi-quantitative MOAKS... (More)

Objective: To determine the association between meniscal body extrusion and bone marrow lesion (BML) development/enlargement in overweight and obese women at high risk of knee osteoarthritis (OA). Design: We used baseline and 30 months follow-up data of the PROOF study, Netherlands, comprising overweight or obese women aged 50–60 years, free of clinical knee OA. All subjects (n = 395) completed a questionnaire on knee complaints and physical activity, underwent physical examination, radiography, and repeated 1.5 T MRI of both knees. Using the mid-coronal MRI slice, one observer measured tibial plateau width and meniscal body extrusion of both menisci in both knees. BMLs and meniscal damage were read using the semi-quantitative MOAKS scoring system by another observer. The association between BML development and meniscal extrusion was primarily analyzed with a random-effects logistic regression model adjusted for age, body weight, body height, physical activity, meniscus damage, knee alignment, and tibia width. In addition, we used a fixed-effect regression model for evaluation of knee-specific factors. Results: In our primary model, there was about 24% increased risk of BML incidence/enlargement per 1 mm extrusion (95% confidence interval [CI] 0.99, 1.57) for medial compartments and 69% risk increase (95% confidence interval [CI] 1.27, 2.25) for the lateral compartments. Results from the fixed-effects regression model were similar, strengthening the validity of the findings. Conclusions: Meniscal body extrusion is an important factor influencing BML development/enlargement, and thus may be a potential treatment target in knee OA development.

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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Bone marrow lesions, Meniscal extrusion, Overweight women
in
Osteoarthritis and Cartilage Open
volume
1
issue
3-4
article number
100015
publisher
Elsevier
external identifiers
  • scopus:85162529498
ISSN
2665-9131
DOI
10.1016/j.ocarto.2019.100015
language
English
LU publication?
yes
id
e92a1cb3-5eb2-4b32-92eb-fa52a507b863
date added to LUP
2023-10-18 09:49:33
date last changed
2023-11-15 14:16:47
@article{e92a1cb3-5eb2-4b32-92eb-fa52a507b863,
  abstract     = {{<p>Objective: To determine the association between meniscal body extrusion and bone marrow lesion (BML) development/enlargement in overweight and obese women at high risk of knee osteoarthritis (OA). Design: We used baseline and 30 months follow-up data of the PROOF study, Netherlands, comprising overweight or obese women aged 50–60 years, free of clinical knee OA. All subjects (n = 395) completed a questionnaire on knee complaints and physical activity, underwent physical examination, radiography, and repeated 1.5 T MRI of both knees. Using the mid-coronal MRI slice, one observer measured tibial plateau width and meniscal body extrusion of both menisci in both knees. BMLs and meniscal damage were read using the semi-quantitative MOAKS scoring system by another observer. The association between BML development and meniscal extrusion was primarily analyzed with a random-effects logistic regression model adjusted for age, body weight, body height, physical activity, meniscus damage, knee alignment, and tibia width. In addition, we used a fixed-effect regression model for evaluation of knee-specific factors. Results: In our primary model, there was about 24% increased risk of BML incidence/enlargement per 1 mm extrusion (95% confidence interval [CI] 0.99, 1.57) for medial compartments and 69% risk increase (95% confidence interval [CI] 1.27, 2.25) for the lateral compartments. Results from the fixed-effects regression model were similar, strengthening the validity of the findings. Conclusions: Meniscal body extrusion is an important factor influencing BML development/enlargement, and thus may be a potential treatment target in knee OA development.</p>}},
  author       = {{Zhang, Fan and Bierma-Zeinstra, Sita M. and Oei, Edwin H.G. and Turkiewicz, Aleksandra and Englund, Martin and Runhaar, Jos}},
  issn         = {{2665-9131}},
  keywords     = {{Bone marrow lesions; Meniscal extrusion; Overweight women}},
  language     = {{eng}},
  month        = {{01}},
  number       = {{3-4}},
  publisher    = {{Elsevier}},
  series       = {{Osteoarthritis and Cartilage Open}},
  title        = {{The association between meniscal body extrusion and the development/enlargement of bone marrow lesions on knee MRI in overweight and obese women}},
  url          = {{http://dx.doi.org/10.1016/j.ocarto.2019.100015}},
  doi          = {{10.1016/j.ocarto.2019.100015}},
  volume       = {{1}},
  year         = {{2020}},
}