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Comparison of three methods to find the vapor activity of a hydration step

Wadsö, Lars LU and Markova, N (2001) In European Journal of Pharmaceutics and Biopharmaceutics 51(1). p.77-81
Abstract
The formation of a stochiometric salt hydrate takes place at a well defined vapor activity. We have compared three methods to measure this vapor activity. In two of the methods we used a sorption balance in step mode and in ramp mode, respectively, and in one method we used a newly developed sorption microcalorimeter. The tests were made with the formation of morphine sulphate pentahydrate from its dihydrate at 25°C. With all three methods this transition was found to take place at a vapor activity close to 0.21.
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author
and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
European Journal of Pharmaceutics and Biopharmaceutics
volume
51
issue
1
pages
77 - 81
publisher
Elsevier
external identifiers
  • scopus:0035168377
ISSN
0939-6411
DOI
10.1016/S0939-6411(00)00134-X
language
English
LU publication?
yes
id
e93584dc-ecac-4e02-81f9-c741532e292b (old id 1034515)
date added to LUP
2016-04-01 12:25:13
date last changed
2025-10-14 11:10:00
@article{e93584dc-ecac-4e02-81f9-c741532e292b,
  abstract     = {{The formation of a stochiometric salt hydrate takes place at a well defined vapor activity. We have compared three methods to measure this vapor activity. In two of the methods we used a sorption balance in step mode and in ramp mode, respectively, and in one method we used a newly developed sorption microcalorimeter. The tests were made with the formation of morphine sulphate pentahydrate from its dihydrate at 25°C. With all three methods this transition was found to take place at a vapor activity close to 0.21.}},
  author       = {{Wadsö, Lars and Markova, N}},
  issn         = {{0939-6411}},
  language     = {{eng}},
  number       = {{1}},
  pages        = {{77--81}},
  publisher    = {{Elsevier}},
  series       = {{European Journal of Pharmaceutics and Biopharmaceutics}},
  title        = {{Comparison of three methods to find the vapor activity of a hydration step}},
  url          = {{http://dx.doi.org/10.1016/S0939-6411(00)00134-X}},
  doi          = {{10.1016/S0939-6411(00)00134-X}},
  volume       = {{51}},
  year         = {{2001}},
}