Admixture mapping reveals loci for carcass mass in red deer x sika hybrids in Kintyre, Scotland
(2021) In G3: Genes, Genomes, Genetics 11(10).- Abstract
We deployed admixture mapping on a sample of 386 deer from a hybrid swarm between native red deer (Cervus elaphus) and introduced Japanese sika (Cervus nippon) sampled in Kintyre, Scotland to search for quantitative trait loci (QTLs) underpinning phenotypic differences between the species. These two species are highly diverged genetically [Fst between pure species, based on 50K single nucleotide polymorphism (SNPs) ¼ 0.532] and phenotypically: pure red have on average twice the carcass mass of pure sika in our sample (38.7 kg vs 19.1 kg). After controlling for sex, age, and population genetic structure, we found 10 autosomal genomic locations with QTL for carcass mass. Effect sizes ranged from 0.191 to 1.839 kg and as... (More)
We deployed admixture mapping on a sample of 386 deer from a hybrid swarm between native red deer (Cervus elaphus) and introduced Japanese sika (Cervus nippon) sampled in Kintyre, Scotland to search for quantitative trait loci (QTLs) underpinning phenotypic differences between the species. These two species are highly diverged genetically [Fst between pure species, based on 50K single nucleotide polymorphism (SNPs) ¼ 0.532] and phenotypically: pure red have on average twice the carcass mass of pure sika in our sample (38.7 kg vs 19.1 kg). After controlling for sex, age, and population genetic structure, we found 10 autosomal genomic locations with QTL for carcass mass. Effect sizes ranged from 0.191 to 1.839 kg and as expected, in all cases the allele derived from sika conferred lower carcass mass. The sika population was fixed for all small carcass mass alleles, whereas the red deer population was typically polymorphic. GO term analysis of genes lying in the QTL regions are associated with oxygen transport. Although body mass is a likely target of selection, none of the SNPs marking QTL are introgressing faster or slower than expected in either direction.
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- author
- McFarlane, S. Eryn LU and Pemberton, Josephine M.
- organization
- publishing date
- 2021-10
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Admixture mapping, C. nippon, Carcass mass, Cervus elaphus, Hybridization
- in
- G3: Genes, Genomes, Genetics
- volume
- 11
- issue
- 10
- article number
- jkab274
- publisher
- Genetics Society of America
- external identifiers
-
- scopus:85115933595
- pmid:34568926
- ISSN
- 2160-1836
- DOI
- 10.1093/g3journal/jkab274
- language
- English
- LU publication?
- yes
- additional info
- Publisher Copyright: © The Author(s) 2021. Published by Oxford University Press on behalf of Genetics Society of America.
- id
- e99432d6-0d6d-4593-a649-896fed9fefcc
- date added to LUP
- 2021-10-21 11:30:04
- date last changed
- 2024-06-15 18:39:51
@article{e99432d6-0d6d-4593-a649-896fed9fefcc,
abstract = {{<p>We deployed admixture mapping on a sample of 386 deer from a hybrid swarm between native red deer (Cervus elaphus) and introduced Japanese sika (Cervus nippon) sampled in Kintyre, Scotland to search for quantitative trait loci (QTLs) underpinning phenotypic differences between the species. These two species are highly diverged genetically [F<sub>st</sub> between pure species, based on 50K single nucleotide polymorphism (SNPs) ¼ 0.532] and phenotypically: pure red have on average twice the carcass mass of pure sika in our sample (38.7 kg vs 19.1 kg). After controlling for sex, age, and population genetic structure, we found 10 autosomal genomic locations with QTL for carcass mass. Effect sizes ranged from 0.191 to 1.839 kg and as expected, in all cases the allele derived from sika conferred lower carcass mass. The sika population was fixed for all small carcass mass alleles, whereas the red deer population was typically polymorphic. GO term analysis of genes lying in the QTL regions are associated with oxygen transport. Although body mass is a likely target of selection, none of the SNPs marking QTL are introgressing faster or slower than expected in either direction.</p>}},
author = {{McFarlane, S. Eryn and Pemberton, Josephine M.}},
issn = {{2160-1836}},
keywords = {{Admixture mapping; C. nippon; Carcass mass; Cervus elaphus; Hybridization}},
language = {{eng}},
number = {{10}},
publisher = {{Genetics Society of America}},
series = {{G3: Genes, Genomes, Genetics}},
title = {{Admixture mapping reveals loci for carcass mass in red deer x sika hybrids in Kintyre, Scotland}},
url = {{http://dx.doi.org/10.1093/g3journal/jkab274}},
doi = {{10.1093/g3journal/jkab274}},
volume = {{11}},
year = {{2021}},
}