Magnetoresponsive fluorescent core-shell nanoclusters for biomedical applications
Saladino, Giovanni Marco ; Kakadiya, Ronak LU
; Ansari, Shaquib Rahman
; Teleki, Alexandra
and Toprak, Muhammet Sadaka
(2023)
In Nanoscale Advances
5(5).
p.1323-1330
- Abstract
Nowadays, superparamagnetic iron oxide nanoparticles (SPIONs) have a dominant role in many subfields of biomedicine. Owing to their peculiar properties, they can be employed for magnetic separation, drug delivery, diagnostics, and hyperthermia treatments. However, these magnetic nanoparticles (NPs) suffer from low unit magnetization due to size constraints (up to 20-30 nm) to exhibit superparamagnetic character. In this work, we have designed and synthesized superparamagnetic nanoclusters (SP-NCs) with diameters of up to 400 nm with high unit magnetization for enhanced loading capacity. These were synthesized with conventional or microwave-assisted solvothermal methods, in the presence of either of the two biomolecules (citrate or... (More)
Nowadays, superparamagnetic iron oxide nanoparticles (SPIONs) have a dominant role in many subfields of biomedicine. Owing to their peculiar properties, they can be employed for magnetic separation, drug delivery, diagnostics, and hyperthermia treatments. However, these magnetic nanoparticles (NPs) suffer from low unit magnetization due to size constraints (up to 20-30 nm) to exhibit superparamagnetic character. In this work, we have designed and synthesized superparamagnetic nanoclusters (SP-NCs) with diameters of up to 400 nm with high unit magnetization for enhanced loading capacity. These were synthesized with conventional or microwave-assisted solvothermal methods, in the presence of either of the two biomolecules (citrate or l-lysine) as the capping agent. Primary particle size, SP-NC size, surface chemistry, and the resultant magnetic properties were observed to be significantly influenced by the choice of synthesis route and capping agent. Selected SP-NCs were then coated with a fluorophore-doped silica shell to provide fluorescence properties, in the near-infrared spectrum region, while silica provided high chemical and colloidal stability. Heating efficiency studies were performed under alternating magnetic field on the synthesized SP-NCs, highlighting their potential in hyperthermia treatment. We envision that their enhanced magnetically-active content, fluorescence, magnetic property, and heating efficiency will pave the way to more effective uses in biomedical applications.
(Less)
- author
- Saladino, Giovanni Marco
; Kakadiya, Ronak
LU
; Ansari, Shaquib Rahman
; Teleki, Alexandra
and Toprak, Muhammet Sadaka
- publishing date
- 2023-01-31
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nanoscale Advances
- volume
- 5
- issue
- 5
- pages
- 8 pages
- publisher
- Royal Society of Chemistry
- external identifiers
-
- scopus:85148631781
- pmid:36866251
- ISSN
- 2516-0230
- DOI
- 10.1039/d2na00887d
- language
- English
- LU publication?
- no
- id
- e9a0dc87-64f7-4c7f-8d49-151101f4b3af
- date added to LUP
- 2023-11-23 14:00:56
- date last changed
- 2024-06-15 22:24:45
@article{e9a0dc87-64f7-4c7f-8d49-151101f4b3af,
abstract = {{<p>Nowadays, superparamagnetic iron oxide nanoparticles (SPIONs) have a dominant role in many subfields of biomedicine. Owing to their peculiar properties, they can be employed for magnetic separation, drug delivery, diagnostics, and hyperthermia treatments. However, these magnetic nanoparticles (NPs) suffer from low unit magnetization due to size constraints (up to 20-30 nm) to exhibit superparamagnetic character. In this work, we have designed and synthesized superparamagnetic nanoclusters (SP-NCs) with diameters of up to 400 nm with high unit magnetization for enhanced loading capacity. These were synthesized with conventional or microwave-assisted solvothermal methods, in the presence of either of the two biomolecules (citrate or l-lysine) as the capping agent. Primary particle size, SP-NC size, surface chemistry, and the resultant magnetic properties were observed to be significantly influenced by the choice of synthesis route and capping agent. Selected SP-NCs were then coated with a fluorophore-doped silica shell to provide fluorescence properties, in the near-infrared spectrum region, while silica provided high chemical and colloidal stability. Heating efficiency studies were performed under alternating magnetic field on the synthesized SP-NCs, highlighting their potential in hyperthermia treatment. We envision that their enhanced magnetically-active content, fluorescence, magnetic property, and heating efficiency will pave the way to more effective uses in biomedical applications.</p>}},
author = {{Saladino, Giovanni Marco and Kakadiya, Ronak and Ansari, Shaquib Rahman and Teleki, Alexandra and Toprak, Muhammet Sadaka}},
issn = {{2516-0230}},
language = {{eng}},
month = {{01}},
number = {{5}},
pages = {{1323--1330}},
publisher = {{Royal Society of Chemistry}},
series = {{Nanoscale Advances}},
title = {{Magnetoresponsive fluorescent core-shell nanoclusters for biomedical applications}},
url = {{http://dx.doi.org/10.1039/d2na00887d}},
doi = {{10.1039/d2na00887d}},
volume = {{5}},
year = {{2023}},
}