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Antibody to the Mr 65,000 isoform of glutamic acid decarboxylase are detected in non-insulin-dependent diabetes in Japanese

Kasuga, A. ; Maruyama, T. ; Ozawa, Y. ; Takei, I. ; Falorni, A. ; Lernmark, Å LU and Saruta, T. (1996) In Journal of Autoimmunity 9(1). p.105-111
Abstract

It was recently reported that antibodies against glutamic acid decarboxylase (GADAb) have a high positive predictive value for insulin-dependency in non-insulin-dependent diabetic (NIDDM) patients. We studied 289 patients classified at onset as having NIDDM. Patients positive for GAD65Ab had a disease onset at a younger age, lower body mass index (BMI) and lower serum C-peptide concentration, and were more often treated with insulin. Among 73 insulin-treated patients, patients with lower C-peptide level (n = 30), C-peptide ≤0.9 ng/ml) showed a higher frequency of GAD65Ab (46.7%) than patients with normal C-peptide (n = 53, C-peptide >0.9; 7.5%, P < 0.0001). The 206 remaining non-insulin-treated patients were divided into 48... (More)

It was recently reported that antibodies against glutamic acid decarboxylase (GADAb) have a high positive predictive value for insulin-dependency in non-insulin-dependent diabetic (NIDDM) patients. We studied 289 patients classified at onset as having NIDDM. Patients positive for GAD65Ab had a disease onset at a younger age, lower body mass index (BMI) and lower serum C-peptide concentration, and were more often treated with insulin. Among 73 insulin-treated patients, patients with lower C-peptide level (n = 30), C-peptide ≤0.9 ng/ml) showed a higher frequency of GAD65Ab (46.7%) than patients with normal C-peptide (n = 53, C-peptide >0.9; 7.5%, P < 0.0001). The 206 remaining non-insulin-treated patients were divided into 48 short-duration (less than 5 years from diagnosis) and 158 long-duration patients. Frequency of GAD65Ab in short-duration patients (10.4%) was significantly higher than that in long-duration patients (3.2%, P < 0.05). Among short-duration patients, there was no significant difference in C-peptide levels between GAD65-positive and negative patients (2.175 and 2.226 ng/ml). In conclusion, GAD65Ab, a marker of insulin deficiency, may predict the development of insulin dependency in non-insulin-dependent Japanese diabetic patients before serum C-peptide concentration decreases.

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author
; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Autoantibody, Autoimmunity, Glutamic acid decarboxylase, Non-insulin-dependent diabetes mellitus
in
Journal of Autoimmunity
volume
9
issue
1
pages
105 - 111
publisher
Elsevier
external identifiers
  • pmid:8845047
  • scopus:0029665614
ISSN
0896-8411
DOI
10.1006/jaut.1996.0013
language
English
LU publication?
no
id
e9d22d50-0d64-4a4e-a73b-af8793b3104a
date added to LUP
2019-07-01 13:28:12
date last changed
2021-02-17 06:52:17
@article{e9d22d50-0d64-4a4e-a73b-af8793b3104a,
  abstract     = {<p>It was recently reported that antibodies against glutamic acid decarboxylase (GADAb) have a high positive predictive value for insulin-dependency in non-insulin-dependent diabetic (NIDDM) patients. We studied 289 patients classified at onset as having NIDDM. Patients positive for GAD65Ab had a disease onset at a younger age, lower body mass index (BMI) and lower serum C-peptide concentration, and were more often treated with insulin. Among 73 insulin-treated patients, patients with lower C-peptide level (n = 30), C-peptide ≤0.9 ng/ml) showed a higher frequency of GAD65Ab (46.7%) than patients with normal C-peptide (n = 53, C-peptide &gt;0.9; 7.5%, P &lt; 0.0001). The 206 remaining non-insulin-treated patients were divided into 48 short-duration (less than 5 years from diagnosis) and 158 long-duration patients. Frequency of GAD65Ab in short-duration patients (10.4%) was significantly higher than that in long-duration patients (3.2%, P &lt; 0.05). Among short-duration patients, there was no significant difference in C-peptide levels between GAD65-positive and negative patients (2.175 and 2.226 ng/ml). In conclusion, GAD65Ab, a marker of insulin deficiency, may predict the development of insulin dependency in non-insulin-dependent Japanese diabetic patients before serum C-peptide concentration decreases.</p>},
  author       = {Kasuga, A. and Maruyama, T. and Ozawa, Y. and Takei, I. and Falorni, A. and Lernmark, Å and Saruta, T.},
  issn         = {0896-8411},
  language     = {eng},
  month        = {01},
  number       = {1},
  pages        = {105--111},
  publisher    = {Elsevier},
  series       = {Journal of Autoimmunity},
  title        = {Antibody to the Mr 65,000 isoform of glutamic acid decarboxylase are detected in non-insulin-dependent diabetes in Japanese},
  url          = {http://dx.doi.org/10.1006/jaut.1996.0013},
  doi          = {10.1006/jaut.1996.0013},
  volume       = {9},
  year         = {1996},
}