Antibody to the Mr 65,000 isoform of glutamic acid decarboxylase are detected in non-insulin-dependent diabetes in Japanese
(1996) In Journal of Autoimmunity 9(1). p.105-111- Abstract
It was recently reported that antibodies against glutamic acid decarboxylase (GADAb) have a high positive predictive value for insulin-dependency in non-insulin-dependent diabetic (NIDDM) patients. We studied 289 patients classified at onset as having NIDDM. Patients positive for GAD65Ab had a disease onset at a younger age, lower body mass index (BMI) and lower serum C-peptide concentration, and were more often treated with insulin. Among 73 insulin-treated patients, patients with lower C-peptide level (n = 30), C-peptide ≤0.9 ng/ml) showed a higher frequency of GAD65Ab (46.7%) than patients with normal C-peptide (n = 53, C-peptide >0.9; 7.5%, P < 0.0001). The 206 remaining non-insulin-treated patients were divided into 48... (More)
It was recently reported that antibodies against glutamic acid decarboxylase (GADAb) have a high positive predictive value for insulin-dependency in non-insulin-dependent diabetic (NIDDM) patients. We studied 289 patients classified at onset as having NIDDM. Patients positive for GAD65Ab had a disease onset at a younger age, lower body mass index (BMI) and lower serum C-peptide concentration, and were more often treated with insulin. Among 73 insulin-treated patients, patients with lower C-peptide level (n = 30), C-peptide ≤0.9 ng/ml) showed a higher frequency of GAD65Ab (46.7%) than patients with normal C-peptide (n = 53, C-peptide >0.9; 7.5%, P < 0.0001). The 206 remaining non-insulin-treated patients were divided into 48 short-duration (less than 5 years from diagnosis) and 158 long-duration patients. Frequency of GAD65Ab in short-duration patients (10.4%) was significantly higher than that in long-duration patients (3.2%, P < 0.05). Among short-duration patients, there was no significant difference in C-peptide levels between GAD65-positive and negative patients (2.175 and 2.226 ng/ml). In conclusion, GAD65Ab, a marker of insulin deficiency, may predict the development of insulin dependency in non-insulin-dependent Japanese diabetic patients before serum C-peptide concentration decreases.
(Less)
- author
- Kasuga, A. ; Maruyama, T. ; Ozawa, Y. ; Takei, I. ; Falorni, A. ; Lernmark, Å LU and Saruta, T.
- publishing date
- 1996-01-01
- type
- Contribution to journal
- publication status
- published
- keywords
- Autoantibody, Autoimmunity, Glutamic acid decarboxylase, Non-insulin-dependent diabetes mellitus
- in
- Journal of Autoimmunity
- volume
- 9
- issue
- 1
- pages
- 105 - 111
- publisher
- Elsevier
- external identifiers
-
- scopus:0029665614
- pmid:8845047
- ISSN
- 0896-8411
- DOI
- 10.1006/jaut.1996.0013
- language
- English
- LU publication?
- no
- id
- e9d22d50-0d64-4a4e-a73b-af8793b3104a
- date added to LUP
- 2019-07-01 13:28:12
- date last changed
- 2024-05-28 20:04:57
@article{e9d22d50-0d64-4a4e-a73b-af8793b3104a, abstract = {{<p>It was recently reported that antibodies against glutamic acid decarboxylase (GADAb) have a high positive predictive value for insulin-dependency in non-insulin-dependent diabetic (NIDDM) patients. We studied 289 patients classified at onset as having NIDDM. Patients positive for GAD65Ab had a disease onset at a younger age, lower body mass index (BMI) and lower serum C-peptide concentration, and were more often treated with insulin. Among 73 insulin-treated patients, patients with lower C-peptide level (n = 30), C-peptide ≤0.9 ng/ml) showed a higher frequency of GAD65Ab (46.7%) than patients with normal C-peptide (n = 53, C-peptide >0.9; 7.5%, P < 0.0001). The 206 remaining non-insulin-treated patients were divided into 48 short-duration (less than 5 years from diagnosis) and 158 long-duration patients. Frequency of GAD65Ab in short-duration patients (10.4%) was significantly higher than that in long-duration patients (3.2%, P < 0.05). Among short-duration patients, there was no significant difference in C-peptide levels between GAD65-positive and negative patients (2.175 and 2.226 ng/ml). In conclusion, GAD65Ab, a marker of insulin deficiency, may predict the development of insulin dependency in non-insulin-dependent Japanese diabetic patients before serum C-peptide concentration decreases.</p>}}, author = {{Kasuga, A. and Maruyama, T. and Ozawa, Y. and Takei, I. and Falorni, A. and Lernmark, Å and Saruta, T.}}, issn = {{0896-8411}}, keywords = {{Autoantibody; Autoimmunity; Glutamic acid decarboxylase; Non-insulin-dependent diabetes mellitus}}, language = {{eng}}, month = {{01}}, number = {{1}}, pages = {{105--111}}, publisher = {{Elsevier}}, series = {{Journal of Autoimmunity}}, title = {{Antibody to the Mr 65,000 isoform of glutamic acid decarboxylase are detected in non-insulin-dependent diabetes in Japanese}}, url = {{http://dx.doi.org/10.1006/jaut.1996.0013}}, doi = {{10.1006/jaut.1996.0013}}, volume = {{9}}, year = {{1996}}, }