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Factors affecting the success of CT-guided core biopsy of musculoskeletal lesions with a 13-G needle

Gataa, Khaldun Ghali ; Inci, Fatih ; Szaro, Pawel and Geijer, Mats LU (2023) In Skeletal Radiology
Abstract

Objective: To determine the value of CT-guided bone core biopsy and investigate factors that affect diagnostic yield and biopsy outcome. Materials and methods: The single-centre retrospective analysis included 447 patients who had CT-guided core biopsy with a 13-G needle (Bonopty®) from January 2016 to December 2021. Histological results or ≥ 6 months of clinical and radiological follow-up served as outcome references. A successful biopsy was classified as “diagnostic” when a definitive diagnosis was made and “adequate” when only the malignant or benign nature of the tumour could be determined. Biopsies were “nondiagnostic” when the nature of the lesion could not be determined. The occult lesions were defined as not seen on CT but... (More)

Objective: To determine the value of CT-guided bone core biopsy and investigate factors that affect diagnostic yield and biopsy outcome. Materials and methods: The single-centre retrospective analysis included 447 patients who had CT-guided core biopsy with a 13-G needle (Bonopty®) from January 2016 to December 2021. Histological results or ≥ 6 months of clinical and radiological follow-up served as outcome references. A successful biopsy was classified as “diagnostic” when a definitive diagnosis was made and “adequate” when only the malignant or benign nature of the tumour could be determined. Biopsies were “nondiagnostic” when the nature of the lesion could not be determined. The occult lesions were defined as not seen on CT but visible on other modalities. Results: In 275 (62%) females and 172 (38%) males, the overall success rate was 85% (383 biopsies), with 314 (70%) diagnostic biopsies and 69 (15%) adequate biopsies. There was no relationship between biopsy success and the localisation of the lesion, length of biopsy material, or number of biopsy attempts. The lesions’ nature had a statistically significant effect on biopsy success with lytic and mixed lesions having the highest success rate. Occult lesions had the lowest success rate. Conclusion: CT-guided bone core biopsy is an effective method in the workup of musculoskeletal diseases with the highest success rate in lytic and mixed lesions. No apparent relationship was found between biopsy success and biopsy length, number of attempts, or localisation of the lesion.

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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Biopsy, Bone tumour, CT-guided, Diagnostic yield, Needle, Tomography, X-ray computed
in
Skeletal Radiology
publisher
Springer
external identifiers
  • pmid:37851081
  • scopus:85174293052
ISSN
0364-2348
DOI
10.1007/s00256-023-04477-3
language
English
LU publication?
yes
additional info
Funding Information: Open access funding provided by University of Gothenburg. All authors (Khaldun Ghali Gataa, Fatih Inci, Pawel Szaro and Mats Geijer) have received funding from the Swedish state under the agreement between the Swedish government and the county councils, the ALF-agreement (71720). Publisher Copyright: © 2023, The Author(s).
id
e9e7dc5d-950e-474a-8667-69c0242465c9
date added to LUP
2023-12-13 14:45:05
date last changed
2024-04-26 08:27:00
@article{e9e7dc5d-950e-474a-8667-69c0242465c9,
  abstract     = {{<p>Objective: To determine the value of CT-guided bone core biopsy and investigate factors that affect diagnostic yield and biopsy outcome. Materials and methods: The single-centre retrospective analysis included 447 patients who had CT-guided core biopsy with a 13-G needle (Bonopty®) from January 2016 to December 2021. Histological results or ≥ 6 months of clinical and radiological follow-up served as outcome references. A successful biopsy was classified as “diagnostic” when a definitive diagnosis was made and “adequate” when only the malignant or benign nature of the tumour could be determined. Biopsies were “nondiagnostic” when the nature of the lesion could not be determined. The occult lesions were defined as not seen on CT but visible on other modalities. Results: In 275 (62%) females and 172 (38%) males, the overall success rate was 85% (383 biopsies), with 314 (70%) diagnostic biopsies and 69 (15%) adequate biopsies. There was no relationship between biopsy success and the localisation of the lesion, length of biopsy material, or number of biopsy attempts. The lesions’ nature had a statistically significant effect on biopsy success with lytic and mixed lesions having the highest success rate. Occult lesions had the lowest success rate. Conclusion: CT-guided bone core biopsy is an effective method in the workup of musculoskeletal diseases with the highest success rate in lytic and mixed lesions. No apparent relationship was found between biopsy success and biopsy length, number of attempts, or localisation of the lesion.</p>}},
  author       = {{Gataa, Khaldun Ghali and Inci, Fatih and Szaro, Pawel and Geijer, Mats}},
  issn         = {{0364-2348}},
  keywords     = {{Biopsy; Bone tumour; CT-guided; Diagnostic yield; Needle; Tomography, X-ray computed}},
  language     = {{eng}},
  publisher    = {{Springer}},
  series       = {{Skeletal Radiology}},
  title        = {{Factors affecting the success of CT-guided core biopsy of musculoskeletal lesions with a 13-G needle}},
  url          = {{http://dx.doi.org/10.1007/s00256-023-04477-3}},
  doi          = {{10.1007/s00256-023-04477-3}},
  year         = {{2023}},
}