Reduced membrane-bound catechol-O-methyltransferase in the liver of spontaneously hypertensive rats
Tsunoda, Makoto ; Tenhunen, Jukka ; Tilgmann, Carola LU
; Arai, Hiroyuki
and Imai, Kazuhiro
(2003)
In Hypertension Research
26(11).
p.923-927
- Abstract
We have previously reported that methylation of catecholamines by catechol-O-methyltransferase (COMT) was attenuated in spontaneously hypertensive rats (SHR) with acute hypotension as compared with that of Wistar-Kyoto (WKY) rats. Here we examined the soluble (S-) and membrane-bound (MB-) COMT activities and COMT protein in the liver, kidney, and erythrocytes in both strains. Both the activities and the amounts of MB-COMT in the liver were lower in SHR than in WKY rats, but no such trend was found in the kidney or erythrocytes. Nor was such a trend observed in any of these three tissues for S-COMT. These results indicate that liver MB-COMT may be a relevant factor in blood pressure regulation in rats.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/ea19ba4a-fb63-4f4c-a074-85333205cf62
- author
- Tsunoda, Makoto
; Tenhunen, Jukka
; Tilgmann, Carola
LU
; Arai, Hiroyuki
and Imai, Kazuhiro
- publishing date
- 2003-11
- type
- Contribution to journal
- publication status
- published
- keywords
- Catechol-O-methyltransferase, Catecholamine, Liver, Membrane-bound
- in
- Hypertension Research
- volume
- 26
- issue
- 11
- pages
- 5 pages
- publisher
- Nature Publishing Group
- external identifiers
-
- pmid:14714585
- scopus:0344237237
- ISSN
- 0916-9636
- DOI
- 10.1291/hypres.26.923
- language
- English
- LU publication?
- no
- id
- ea19ba4a-fb63-4f4c-a074-85333205cf62
- date added to LUP
- 2016-04-11 13:04:59
- date last changed
- 2024-01-04 01:09:24
@article{ea19ba4a-fb63-4f4c-a074-85333205cf62,
abstract = {{<p>We have previously reported that methylation of catecholamines by catechol-O-methyltransferase (COMT) was attenuated in spontaneously hypertensive rats (SHR) with acute hypotension as compared with that of Wistar-Kyoto (WKY) rats. Here we examined the soluble (S-) and membrane-bound (MB-) COMT activities and COMT protein in the liver, kidney, and erythrocytes in both strains. Both the activities and the amounts of MB-COMT in the liver were lower in SHR than in WKY rats, but no such trend was found in the kidney or erythrocytes. Nor was such a trend observed in any of these three tissues for S-COMT. These results indicate that liver MB-COMT may be a relevant factor in blood pressure regulation in rats.</p>}},
author = {{Tsunoda, Makoto and Tenhunen, Jukka and Tilgmann, Carola and Arai, Hiroyuki and Imai, Kazuhiro}},
issn = {{0916-9636}},
keywords = {{Catechol-O-methyltransferase; Catecholamine; Liver; Membrane-bound}},
language = {{eng}},
number = {{11}},
pages = {{923--927}},
publisher = {{Nature Publishing Group}},
series = {{Hypertension Research}},
title = {{Reduced membrane-bound catechol-O-methyltransferase in the liver of spontaneously hypertensive rats}},
url = {{http://dx.doi.org/10.1291/hypres.26.923}},
doi = {{10.1291/hypres.26.923}},
volume = {{26}},
year = {{2003}},
}