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Reduced membrane-bound catechol-O-methyltransferase in the liver of spontaneously hypertensive rats

Tsunoda, Makoto ; Tenhunen, Jukka ; Tilgmann, Carola LU orcid ; Arai, Hiroyuki and Imai, Kazuhiro (2003) In Hypertension Research 26(11). p.923-927
Abstract

We have previously reported that methylation of catecholamines by catechol-O-methyltransferase (COMT) was attenuated in spontaneously hypertensive rats (SHR) with acute hypotension as compared with that of Wistar-Kyoto (WKY) rats. Here we examined the soluble (S-) and membrane-bound (MB-) COMT activities and COMT protein in the liver, kidney, and erythrocytes in both strains. Both the activities and the amounts of MB-COMT in the liver were lower in SHR than in WKY rats, but no such trend was found in the kidney or erythrocytes. Nor was such a trend observed in any of these three tissues for S-COMT. These results indicate that liver MB-COMT may be a relevant factor in blood pressure regulation in rats.

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author
; ; ; and
publishing date
type
Contribution to journal
publication status
published
keywords
Catechol-O-methyltransferase, Catecholamine, Liver, Membrane-bound
in
Hypertension Research
volume
26
issue
11
pages
5 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:0344237237
  • pmid:14714585
ISSN
0916-9636
DOI
10.1291/hypres.26.923
language
English
LU publication?
no
id
ea19ba4a-fb63-4f4c-a074-85333205cf62
date added to LUP
2016-04-11 13:04:59
date last changed
2024-01-04 01:09:24
@article{ea19ba4a-fb63-4f4c-a074-85333205cf62,
  abstract     = {{<p>We have previously reported that methylation of catecholamines by catechol-O-methyltransferase (COMT) was attenuated in spontaneously hypertensive rats (SHR) with acute hypotension as compared with that of Wistar-Kyoto (WKY) rats. Here we examined the soluble (S-) and membrane-bound (MB-) COMT activities and COMT protein in the liver, kidney, and erythrocytes in both strains. Both the activities and the amounts of MB-COMT in the liver were lower in SHR than in WKY rats, but no such trend was found in the kidney or erythrocytes. Nor was such a trend observed in any of these three tissues for S-COMT. These results indicate that liver MB-COMT may be a relevant factor in blood pressure regulation in rats.</p>}},
  author       = {{Tsunoda, Makoto and Tenhunen, Jukka and Tilgmann, Carola and Arai, Hiroyuki and Imai, Kazuhiro}},
  issn         = {{0916-9636}},
  keywords     = {{Catechol-O-methyltransferase; Catecholamine; Liver; Membrane-bound}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{923--927}},
  publisher    = {{Nature Publishing Group}},
  series       = {{Hypertension Research}},
  title        = {{Reduced membrane-bound catechol-O-methyltransferase in the liver of spontaneously hypertensive rats}},
  url          = {{http://dx.doi.org/10.1291/hypres.26.923}},
  doi          = {{10.1291/hypres.26.923}},
  volume       = {{26}},
  year         = {{2003}},
}