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Reduced membrane-bound catechol-O-methyltransferase in the liver of spontaneously hypertensive rats

Tsunoda, Makoto; Tenhunen, Jukka; Tilgmann, Carola LU ; Arai, Hiroyuki and Imai, Kazuhiro (2003) In Hypertension Research 26(11). p.923-927
Abstract

We have previously reported that methylation of catecholamines by catechol-O-methyltransferase (COMT) was attenuated in spontaneously hypertensive rats (SHR) with acute hypotension as compared with that of Wistar-Kyoto (WKY) rats. Here we examined the soluble (S-) and membrane-bound (MB-) COMT activities and COMT protein in the liver, kidney, and erythrocytes in both strains. Both the activities and the amounts of MB-COMT in the liver were lower in SHR than in WKY rats, but no such trend was found in the kidney or erythrocytes. Nor was such a trend observed in any of these three tissues for S-COMT. These results indicate that liver MB-COMT may be a relevant factor in blood pressure regulation in rats.

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author
publishing date
type
Contribution to journal
publication status
published
keywords
Catechol-O-methyltransferase, Catecholamine, Liver, Membrane-bound
in
Hypertension Research
volume
26
issue
11
pages
5 pages
publisher
Nature Publishing Group
external identifiers
  • scopus:0344237237
ISSN
0916-9636
DOI
10.1291/hypres.26.923
language
English
LU publication?
no
id
ea19ba4a-fb63-4f4c-a074-85333205cf62
date added to LUP
2016-04-11 13:04:59
date last changed
2017-07-23 05:12:32
@article{ea19ba4a-fb63-4f4c-a074-85333205cf62,
  abstract     = {<p>We have previously reported that methylation of catecholamines by catechol-O-methyltransferase (COMT) was attenuated in spontaneously hypertensive rats (SHR) with acute hypotension as compared with that of Wistar-Kyoto (WKY) rats. Here we examined the soluble (S-) and membrane-bound (MB-) COMT activities and COMT protein in the liver, kidney, and erythrocytes in both strains. Both the activities and the amounts of MB-COMT in the liver were lower in SHR than in WKY rats, but no such trend was found in the kidney or erythrocytes. Nor was such a trend observed in any of these three tissues for S-COMT. These results indicate that liver MB-COMT may be a relevant factor in blood pressure regulation in rats.</p>},
  author       = {Tsunoda, Makoto and Tenhunen, Jukka and Tilgmann, Carola and Arai, Hiroyuki and Imai, Kazuhiro},
  issn         = {0916-9636},
  keyword      = {Catechol-O-methyltransferase,Catecholamine,Liver,Membrane-bound},
  language     = {eng},
  number       = {11},
  pages        = {923--927},
  publisher    = {Nature Publishing Group},
  series       = {Hypertension Research},
  title        = {Reduced membrane-bound catechol-O-methyltransferase in the liver of spontaneously hypertensive rats},
  url          = {http://dx.doi.org/10.1291/hypres.26.923},
  volume       = {26},
  year         = {2003},
}