Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Carbohydrate-deficient transferrin measured by high-performance liquid chromatography and CDTect immunoassay

Simonsson, Per LU ; Lindberg, S and Alling, Christer LU (1996) In Alcohol and Alcoholism 31(4). p.397-402
Abstract
Carbohydrate-deficient transferrin (CDT) was measured in three populations using anion-exchange chromatography followed by radioimmunoassay (CDTectTM) and a new high-performance liquid chromatography (HPLC) method. The correlation between the methods in 50 consecutive clinical samples was good (r = 0.87). However, in a set of 49 samples with CDT concentrations close to the reference value of the methods, the correlation was low (r = 0.51). In addition, among controls, no correlation between the methods was found (r = 0.10). Abnormal isoforms of transferrin were noted in 5% of the clinical samples. HPLC determination of CDT offers the advantage of identifying these isoforms of transferrin and thus reducing analytical pitfalls associated... (More)
Carbohydrate-deficient transferrin (CDT) was measured in three populations using anion-exchange chromatography followed by radioimmunoassay (CDTectTM) and a new high-performance liquid chromatography (HPLC) method. The correlation between the methods in 50 consecutive clinical samples was good (r = 0.87). However, in a set of 49 samples with CDT concentrations close to the reference value of the methods, the correlation was low (r = 0.51). In addition, among controls, no correlation between the methods was found (r = 0.10). Abnormal isoforms of transferrin were noted in 5% of the clinical samples. HPLC determination of CDT offers the advantage of identifying these isoforms of transferrin and thus reducing analytical pitfalls associated with the CDTectTM method. (Less)
Please use this url to cite or link to this publication:
author
; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Alcohol and Alcoholism
volume
31
issue
4
pages
397 - 402
publisher
Oxford University Press
external identifiers
  • pmid:8879289
  • scopus:0029743406
ISSN
1464-3502
language
English
LU publication?
yes
id
ea2930c2-105c-476a-825a-4b9db124d83d (old id 1110826)
alternative location
http://alcalc.oxfordjournals.org/cgi/reprint/31/4/397.pdf
date added to LUP
2016-04-01 12:38:24
date last changed
2022-01-27 07:50:28
@article{ea2930c2-105c-476a-825a-4b9db124d83d,
  abstract     = {{Carbohydrate-deficient transferrin (CDT) was measured in three populations using anion-exchange chromatography followed by radioimmunoassay (CDTectTM) and a new high-performance liquid chromatography (HPLC) method. The correlation between the methods in 50 consecutive clinical samples was good (r = 0.87). However, in a set of 49 samples with CDT concentrations close to the reference value of the methods, the correlation was low (r = 0.51). In addition, among controls, no correlation between the methods was found (r = 0.10). Abnormal isoforms of transferrin were noted in 5% of the clinical samples. HPLC determination of CDT offers the advantage of identifying these isoforms of transferrin and thus reducing analytical pitfalls associated with the CDTectTM method.}},
  author       = {{Simonsson, Per and Lindberg, S and Alling, Christer}},
  issn         = {{1464-3502}},
  language     = {{eng}},
  number       = {{4}},
  pages        = {{397--402}},
  publisher    = {{Oxford University Press}},
  series       = {{Alcohol and Alcoholism}},
  title        = {{Carbohydrate-deficient transferrin measured by high-performance liquid chromatography and CDTect immunoassay}},
  url          = {{http://alcalc.oxfordjournals.org/cgi/reprint/31/4/397.pdf}},
  volume       = {{31}},
  year         = {{1996}},
}