No effect of diclofenac on the pharmacokinetics of cloxacillin
Nergelius, Görel LU ; Vinge, Ellen LU ; Bengtsson, Hans-Inge ; Björkman, Roland and Grubb, A LU
(1997)
In Basic and Clinical Pharmacology and Toxicology
81.
p.26-30
- Abstract
We studied the influence of diclofenac on the pharmacokinetics of cloxacillin in healthy volunteers, 60 years or older, as well as the possible effect of cloxacillin and diclofenac on urinary protein excretion. In a randomized, double-blind, cross-over study 15 subjects were given 1 g cloxacillin, and placebo or 75 mg diclofenac, as single intravenous doses. Plasma concentrations of cloxacillin were followed over 10.5 hr, and urine excretion of cloxacillin over 24 hr. The effect of the drugs on urinary excretion of protein indicators of glomerular (albumin, IgG) and tubular (protein HC) function was also studied. Total plasma clearance of cloxacillin was with placebo 219 +/- 51 (mean +/- S.D.), and with diclofenac 212 +/- 39... (More)
We studied the influence of diclofenac on the pharmacokinetics of cloxacillin in healthy volunteers, 60 years or older, as well as the possible effect of cloxacillin and diclofenac on urinary protein excretion. In a randomized, double-blind, cross-over study 15 subjects were given 1 g cloxacillin, and placebo or 75 mg diclofenac, as single intravenous doses. Plasma concentrations of cloxacillin were followed over 10.5 hr, and urine excretion of cloxacillin over 24 hr. The effect of the drugs on urinary excretion of protein indicators of glomerular (albumin, IgG) and tubular (protein HC) function was also studied. Total plasma clearance of cloxacillin was with placebo 219 +/- 51 (mean +/- S.D.), and with diclofenac 212 +/- 39 ml/min./1.73 m2 (ns); renal clearance was 97 +/- 21 and 96 +/- 24 ml/min./1.73 m2, respectively (ns). The terminal t1/2 of cloxacillin was 1.03 +/- 0.42 hr with placebo, and 1.12 +/- 0.37 with diclofenac (ns). The mean ratio of AUC0-infinity's (cloxacillin plus diclofenac/cloxacillin plus placebo) was 1.03 (90% CI: 0.99, 1.08). Urinary excretion of the proteins was low and was not increased by cloxacillin or diclofenac. In healthy volunteers, 60 years or older, diclofenac does not alter cloxacillin pharmacokinetics, and neither cloxacillin nor diclofenac in single intravenous doses cause renal dysfunction.
(Less)
- author
- Nergelius, Görel
LU
; Vinge, Ellen
LU
; Bengtsson, Hans-Inge
; Björkman, Roland
and Grubb, A
LU
- publishing date
- 1997
- type
- Contribution to journal
- publication status
- published
- keywords
- Aged, Aged, 80 and over, Albuminuria, Anti-Inflammatory Agents, Non-Steroidal/pharmacology, Cloxacillin/blood, Creatinine/urine, Cross-Over Studies, Diclofenac/pharmacology, Double-Blind Method, Female, Humans, Kidney/drug effects, Male, Middle Aged, Penicillins/blood, Proteins/drug effects, Time Factors
- in
- Basic and Clinical Pharmacology and Toxicology
- volume
- 81
- pages
- 26 - 30
- publisher
- Wiley-Blackwell
- external identifiers
-
- scopus:0030746625
- pmid:9258981
- ISSN
- 0901-9928
- DOI
- 10.1111/j.1600-0773.1997.tb00026.x
- language
- English
- LU publication?
- no
- id
- ea3e315c-5758-4b6a-b07c-d8952e8ce7a4
- date added to LUP
- 2021-10-29 10:17:34
- date last changed
- 2024-01-12 02:55:17
@article{ea3e315c-5758-4b6a-b07c-d8952e8ce7a4,
abstract = {{<p>We studied the influence of diclofenac on the pharmacokinetics of cloxacillin in healthy volunteers, 60 years or older, as well as the possible effect of cloxacillin and diclofenac on urinary protein excretion. In a randomized, double-blind, cross-over study 15 subjects were given 1 g cloxacillin, and placebo or 75 mg diclofenac, as single intravenous doses. Plasma concentrations of cloxacillin were followed over 10.5 hr, and urine excretion of cloxacillin over 24 hr. The effect of the drugs on urinary excretion of protein indicators of glomerular (albumin, IgG) and tubular (protein HC) function was also studied. Total plasma clearance of cloxacillin was with placebo 219 +/- 51 (mean +/- S.D.), and with diclofenac 212 +/- 39 ml/min./1.73 m2 (ns); renal clearance was 97 +/- 21 and 96 +/- 24 ml/min./1.73 m2, respectively (ns). The terminal t1/2 of cloxacillin was 1.03 +/- 0.42 hr with placebo, and 1.12 +/- 0.37 with diclofenac (ns). The mean ratio of AUC0-infinity's (cloxacillin plus diclofenac/cloxacillin plus placebo) was 1.03 (90% CI: 0.99, 1.08). Urinary excretion of the proteins was low and was not increased by cloxacillin or diclofenac. In healthy volunteers, 60 years or older, diclofenac does not alter cloxacillin pharmacokinetics, and neither cloxacillin nor diclofenac in single intravenous doses cause renal dysfunction.</p>}},
author = {{Nergelius, Görel and Vinge, Ellen and Bengtsson, Hans-Inge and Björkman, Roland and Grubb, A}},
issn = {{0901-9928}},
keywords = {{Aged; Aged, 80 and over; Albuminuria; Anti-Inflammatory Agents, Non-Steroidal/pharmacology; Cloxacillin/blood; Creatinine/urine; Cross-Over Studies; Diclofenac/pharmacology; Double-Blind Method; Female; Humans; Kidney/drug effects; Male; Middle Aged; Penicillins/blood; Proteins/drug effects; Time Factors}},
language = {{eng}},
pages = {{26--30}},
publisher = {{Wiley-Blackwell}},
series = {{Basic and Clinical Pharmacology and Toxicology}},
title = {{No effect of diclofenac on the pharmacokinetics of cloxacillin}},
url = {{http://dx.doi.org/10.1111/j.1600-0773.1997.tb00026.x}},
doi = {{10.1111/j.1600-0773.1997.tb00026.x}},
volume = {{81}},
year = {{1997}},
}