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A new perspective for advanced positron emission tomography–based molecular imaging in neurodegenerative proteinopathies

, ; Perani, Daniela; Iaccarino, Leonardo; Lammertsma, Adriaan A.; Windhorst, Albert D.; Edison, Paul; Boellaard, Ronald; Hansson, Oskar LU ; Nordberg, Agneta and Jacobs, Andreas H. (2019) In Alzheimer's and Dementia
Abstract

Recent studies in neurodegenerative conditions have increasingly highlighted that the same neuropathology can trigger different clinical phenotypes or, vice-versa, that similar phenotypes can be triggered by different neuropathologies. This evidence has called for the adoption of a pathology spectrum-based approach to study neurodegenerative proteinopathies. These conditions share brain deposition of abnormal protein aggregates, leading to aberrant biochemical, metabolic, functional, and structural changes. Positron emission tomography (PET) is a well-recognized and unique tool for the in vivo assessment of brain neuropathology, and novel PET techniques are emerging for the study of specific protein species. Today, key applications of... (More)

Recent studies in neurodegenerative conditions have increasingly highlighted that the same neuropathology can trigger different clinical phenotypes or, vice-versa, that similar phenotypes can be triggered by different neuropathologies. This evidence has called for the adoption of a pathology spectrum-based approach to study neurodegenerative proteinopathies. These conditions share brain deposition of abnormal protein aggregates, leading to aberrant biochemical, metabolic, functional, and structural changes. Positron emission tomography (PET) is a well-recognized and unique tool for the in vivo assessment of brain neuropathology, and novel PET techniques are emerging for the study of specific protein species. Today, key applications of PET range from early research and clinical diagnostic tools to their use in clinical trials for both participants screening and outcome evaluation. This position article critically reviews the role of distinct PET molecular tracers for different neurodegenerative proteinopathies, highlighting their strengths, weaknesses, and opportunities, with special emphasis on methodological challenges and future applications.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
Amyloid, Neuroinflammation, PET molecular imaging, Protheinopathies, Radiotracers, Tau
in
Alzheimer's and Dementia
publisher
Elsevier
external identifiers
  • scopus:85067487439
ISSN
1552-5260
DOI
10.1016/j.jalz.2019.02.004
language
English
LU publication?
yes
id
ea57e09d-c6a0-4ceb-824a-f31c62914a7d
date added to LUP
2019-07-05 13:46:03
date last changed
2019-07-30 05:06:09
@article{ea57e09d-c6a0-4ceb-824a-f31c62914a7d,
  abstract     = {<p>Recent studies in neurodegenerative conditions have increasingly highlighted that the same neuropathology can trigger different clinical phenotypes or, vice-versa, that similar phenotypes can be triggered by different neuropathologies. This evidence has called for the adoption of a pathology spectrum-based approach to study neurodegenerative proteinopathies. These conditions share brain deposition of abnormal protein aggregates, leading to aberrant biochemical, metabolic, functional, and structural changes. Positron emission tomography (PET) is a well-recognized and unique tool for the in vivo assessment of brain neuropathology, and novel PET techniques are emerging for the study of specific protein species. Today, key applications of PET range from early research and clinical diagnostic tools to their use in clinical trials for both participants screening and outcome evaluation. This position article critically reviews the role of distinct PET molecular tracers for different neurodegenerative proteinopathies, highlighting their strengths, weaknesses, and opportunities, with special emphasis on methodological challenges and future applications.</p>},
  author       = {,  and Perani, Daniela and Iaccarino, Leonardo and Lammertsma, Adriaan A. and Windhorst, Albert D. and Edison, Paul and Boellaard, Ronald and Hansson, Oskar and Nordberg, Agneta and Jacobs, Andreas H.},
  issn         = {1552-5260},
  keyword      = {Amyloid,Neuroinflammation,PET molecular imaging,Protheinopathies,Radiotracers,Tau},
  language     = {eng},
  month        = {06},
  publisher    = {Elsevier},
  series       = {Alzheimer's and Dementia},
  title        = {A new perspective for advanced positron emission tomography–based molecular imaging in neurodegenerative proteinopathies},
  url          = {http://dx.doi.org/10.1016/j.jalz.2019.02.004},
  year         = {2019},
}