Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Gold-based drug encapsulation within a ferritin nanocage : X-ray structure and biological evaluation as a potential anticancer agent of the Auoxo3-loaded protein

Ferraro, Giarita ; Monti, Daria Maria ; Amoresano, Angela ; Pontillo, Nicola ; Petruk, Ganna LU orcid ; Pane, Francesca ; Cinellu, Maria Agostina and Merlino, Antonello (2016) In Chemical Communications 52(61). p.9518-9521
Abstract

Auoxo3, a cytotoxic gold(iii) compound, was encapsulated within a ferritin nanocage. Inductively coupled plasma mass spectrometry, circular dichroism, UV-Vis absorption spectroscopy and X-ray crystallography confirm the potential-drug encapsulation. The structure shows that naked Au(i) ions bind to the side chains of Cys48, His49, His114, His114 and Cys126, Cys126, His132, His147. The gold-encapsulated nanocarrier has a cytotoxic effect on different aggressive human cancer cells, whereas it is significantly less cytotoxic for non-tumorigenic cells.

Please use this url to cite or link to this publication:
author
; ; ; ; ; ; and
publishing date
type
Contribution to journal
publication status
published
in
Chemical Communications
volume
52
issue
61
pages
9518 - 9521
publisher
Royal Society of Chemistry
external identifiers
  • pmid:27326513
  • scopus:84979641073
ISSN
1359-7345
DOI
10.1039/c6cc02516a
language
English
LU publication?
no
additional info
Publisher Copyright: © The Royal Society of Chemistry 2016.
id
ea5d9eed-084b-4980-9d2c-cdb778115858
date added to LUP
2025-01-21 15:44:24
date last changed
2025-06-11 02:30:05
@article{ea5d9eed-084b-4980-9d2c-cdb778115858,
  abstract     = {{<p>Auoxo3, a cytotoxic gold(iii) compound, was encapsulated within a ferritin nanocage. Inductively coupled plasma mass spectrometry, circular dichroism, UV-Vis absorption spectroscopy and X-ray crystallography confirm the potential-drug encapsulation. The structure shows that naked Au(i) ions bind to the side chains of Cys48, His49, His114, His114 and Cys126, Cys126, His132, His147. The gold-encapsulated nanocarrier has a cytotoxic effect on different aggressive human cancer cells, whereas it is significantly less cytotoxic for non-tumorigenic cells.</p>}},
  author       = {{Ferraro, Giarita and Monti, Daria Maria and Amoresano, Angela and Pontillo, Nicola and Petruk, Ganna and Pane, Francesca and Cinellu, Maria Agostina and Merlino, Antonello}},
  issn         = {{1359-7345}},
  language     = {{eng}},
  number       = {{61}},
  pages        = {{9518--9521}},
  publisher    = {{Royal Society of Chemistry}},
  series       = {{Chemical Communications}},
  title        = {{Gold-based drug encapsulation within a ferritin nanocage : X-ray structure and biological evaluation as a potential anticancer agent of the Auoxo3-loaded protein}},
  url          = {{http://dx.doi.org/10.1039/c6cc02516a}},
  doi          = {{10.1039/c6cc02516a}},
  volume       = {{52}},
  year         = {{2016}},
}