Cerebrospinal fluid neurofilament light concentration in motor neuron disease and frontotemporal dementia predicts survival
Skillbäck, Tobias ; Mattsson, Niklas LU
; Blennow, Kaj
LU
and Zetterberg, Henrik
LU
(2017)
In Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
18(5-6).
p.397-403
- Abstract
Objective: To aid diagnostics, patient stratification and studies seeking to find treatments for the related diseases motor neuron disease (MND) and frontotemporal dementia (FTD), there is a need to establish a way to assess disease severity and the amount of ongoing neurodegeneration. Previous studies have suggested that cerebrospinal fluid (CSF) neurofilament light (NFL) may serve this purpose. Methods: We cross-referenced the Swedish mortality registry with the laboratory database at Sahlgrenska University Hospital to produce a dataset of CSF NFL concentrations and mortality information for 715 MND patients, 87 FTD patients, and 107 healthy controls. Biomarker concentrations were analysed in relation to recorded cause of death and... (More)
Objective: To aid diagnostics, patient stratification and studies seeking to find treatments for the related diseases motor neuron disease (MND) and frontotemporal dementia (FTD), there is a need to establish a way to assess disease severity and the amount of ongoing neurodegeneration. Previous studies have suggested that cerebrospinal fluid (CSF) neurofilament light (NFL) may serve this purpose. Methods: We cross-referenced the Swedish mortality registry with the laboratory database at Sahlgrenska University Hospital to produce a dataset of CSF NFL concentrations and mortality information for 715 MND patients, 87 FTD patients, and 107 healthy controls. Biomarker concentrations were analysed in relation to recorded cause of death and time of death. Results: MND patients had significantly higher CSF NFL concentrations than FTD patients. Both groups had significantly higher concentrations than the healthy controls (mean 709% increase in MND and 307% increase in FTD). Higher concentrations of CSF NFL were associated with shorter survival in both MND and FTD. Conclusions: The results of this study strengthen the notion of CSF NFL as a useful tool for determining disease intensity in MND and FTD patients. Further studies in patient cohorts with clinically subtyped and genetically classified diagnoses are needed.
(Less)
- author
- Skillbäck, Tobias
; Mattsson, Niklas
LU
; Blennow, Kaj
LU
and Zetterberg, Henrik
LU
- organization
- publishing date
- 2017-02-06
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- amyotrophic lateral sclerosis, Biomarkers in CSF, frontotemporal dementia, motor neuron disease, neurofilament light protein
- in
- Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration
- volume
- 18
- issue
- 5-6
- pages
- 397 - 403
- publisher
- Informa Healthcare
- external identifiers
-
- pmid:28631955
- wos:000405584600010
- scopus:85011866920
- ISSN
- 2167-8421
- DOI
- 10.1080/21678421.2017.1281962
- language
- English
- LU publication?
- yes
- id
- ea5ded2e-fd9e-439a-8252-da392bebadce
- date added to LUP
- 2017-02-27 14:37:47
- date last changed
- 2025-02-04 13:45:43
@article{ea5ded2e-fd9e-439a-8252-da392bebadce,
abstract = {{<p>Objective: To aid diagnostics, patient stratification and studies seeking to find treatments for the related diseases motor neuron disease (MND) and frontotemporal dementia (FTD), there is a need to establish a way to assess disease severity and the amount of ongoing neurodegeneration. Previous studies have suggested that cerebrospinal fluid (CSF) neurofilament light (NFL) may serve this purpose. Methods: We cross-referenced the Swedish mortality registry with the laboratory database at Sahlgrenska University Hospital to produce a dataset of CSF NFL concentrations and mortality information for 715 MND patients, 87 FTD patients, and 107 healthy controls. Biomarker concentrations were analysed in relation to recorded cause of death and time of death. Results: MND patients had significantly higher CSF NFL concentrations than FTD patients. Both groups had significantly higher concentrations than the healthy controls (mean 709% increase in MND and 307% increase in FTD). Higher concentrations of CSF NFL were associated with shorter survival in both MND and FTD. Conclusions: The results of this study strengthen the notion of CSF NFL as a useful tool for determining disease intensity in MND and FTD patients. Further studies in patient cohorts with clinically subtyped and genetically classified diagnoses are needed.</p>}},
author = {{Skillbäck, Tobias and Mattsson, Niklas and Blennow, Kaj and Zetterberg, Henrik}},
issn = {{2167-8421}},
keywords = {{amyotrophic lateral sclerosis; Biomarkers in CSF; frontotemporal dementia; motor neuron disease; neurofilament light protein}},
language = {{eng}},
month = {{02}},
number = {{5-6}},
pages = {{397--403}},
publisher = {{Informa Healthcare}},
series = {{Amyotrophic Lateral Sclerosis and Frontotemporal Degeneration}},
title = {{Cerebrospinal fluid neurofilament light concentration in motor neuron disease and frontotemporal dementia predicts survival}},
url = {{http://dx.doi.org/10.1080/21678421.2017.1281962}},
doi = {{10.1080/21678421.2017.1281962}},
volume = {{18}},
year = {{2017}},
}