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Magnetic resonance-guided, vacuum-assisted breast biopsy - Results from a European Multicenter Study of 538 lesions

Perlet, C ; Heywang-Kobrunner, SH ; Heinig, A ; Sittek, H ; Casselman, J ; Andersson, Ingvar LU and Taourel, P (2006) In Cancer 106(5). p.982-990
Abstract
BACKGROUND. The objective of this study was to determine the accuracy, reproducibility, and clinical value of magnetic resonance (MR)-guided, vacuum-assisted breast biopsy (MR-VAB) in a prospective, multicenter study. METHODS. in 5 European centers, MR-VAB was performed or attempted on 538 suspicious lesions that were visible or could targeted only by MR imaging (MRI). Verification of malignant or borderline lesions included reexcision of the biopsy cavity. Benign biopsy results were verified by retrospective correlation of histology with preinterventional and postinterventional MRI studies. Follow-up of 24-48 months (median, 32 months) was available for 491 of 538 patients. RESULTS. MR-VAB was unsuccessful or was not completed in 21 of... (More)
BACKGROUND. The objective of this study was to determine the accuracy, reproducibility, and clinical value of magnetic resonance (MR)-guided, vacuum-assisted breast biopsy (MR-VAB) in a prospective, multicenter study. METHODS. in 5 European centers, MR-VAB was performed or attempted on 538 suspicious lesions that were visible or could targeted only by MR imaging (MRI). Verification of malignant or borderline lesions included reexcision of the biopsy cavity. Benign biopsy results were verified by retrospective correlation of histology with preinterventional and postinterventional MRI studies. Follow-up of 24-48 months (median, 32 months) was available for 491 of 538 patients. RESULTS. MR-VAB was unsuccessful or was not completed in 21 of 538 patients, for which an immediate repeat biopsy was recommended. Five hundred seventeen of 538 performed VAB procedures (96%) were successful. Histology yielded 138 (27%) malignancies, 17 (3%) atypical ductal hyperplasias, and 362 (70%) benign entities. No false-negative diagnoses occurred among the 517 successful MR-VAB procedures. The positive predictive value of VAB depended on patient preselection, which differed according to the indication for the initial MRI study. CONCLUSIONS. The results of this study indicated that MR-VAB offers excellent accuracy. Small lesion size did not prove to be a limitation. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
intervention, biopsy, breast, magnetic resonance imaging
in
Cancer
volume
106
issue
5
pages
982 - 990
publisher
John Wiley & Sons
external identifiers
  • pmid:16456807
  • wos:000235822700002
  • scopus:33644540773
ISSN
1097-0142
DOI
10.1002/cncr.21720
language
English
LU publication?
yes
id
ea623496-de43-4c79-b53b-399156dd6db1 (old id 693568)
date added to LUP
2016-04-01 12:34:45
date last changed
2020-02-12 04:07:34
@article{ea623496-de43-4c79-b53b-399156dd6db1,
  abstract     = {BACKGROUND. The objective of this study was to determine the accuracy, reproducibility, and clinical value of magnetic resonance (MR)-guided, vacuum-assisted breast biopsy (MR-VAB) in a prospective, multicenter study. METHODS. in 5 European centers, MR-VAB was performed or attempted on 538 suspicious lesions that were visible or could targeted only by MR imaging (MRI). Verification of malignant or borderline lesions included reexcision of the biopsy cavity. Benign biopsy results were verified by retrospective correlation of histology with preinterventional and postinterventional MRI studies. Follow-up of 24-48 months (median, 32 months) was available for 491 of 538 patients. RESULTS. MR-VAB was unsuccessful or was not completed in 21 of 538 patients, for which an immediate repeat biopsy was recommended. Five hundred seventeen of 538 performed VAB procedures (96%) were successful. Histology yielded 138 (27%) malignancies, 17 (3%) atypical ductal hyperplasias, and 362 (70%) benign entities. No false-negative diagnoses occurred among the 517 successful MR-VAB procedures. The positive predictive value of VAB depended on patient preselection, which differed according to the indication for the initial MRI study. CONCLUSIONS. The results of this study indicated that MR-VAB offers excellent accuracy. Small lesion size did not prove to be a limitation.},
  author       = {Perlet, C and Heywang-Kobrunner, SH and Heinig, A and Sittek, H and Casselman, J and Andersson, Ingvar and Taourel, P},
  issn         = {1097-0142},
  language     = {eng},
  number       = {5},
  pages        = {982--990},
  publisher    = {John Wiley & Sons},
  series       = {Cancer},
  title        = {Magnetic resonance-guided, vacuum-assisted breast biopsy - Results from a European Multicenter Study of 538 lesions},
  url          = {http://dx.doi.org/10.1002/cncr.21720},
  doi          = {10.1002/cncr.21720},
  volume       = {106},
  year         = {2006},
}