Advanced

Reduced voluntary non-visual suppression of the vestibulo-ocular reflex gain during nitrous oxide narcosis

Padoan, S; Magnusson, M LU ; Akesson, M and Ornhagen, H (1992) In Aviation Space and Environmental Medicine 63(10). p.80-875
Abstract

The effect of subanesthetic nitrous oxide (N2O) narcosis (21%) on the vestibulo-ocular reflex (VOR) and on voluntary non-visual suppression of the VOR was studied in 12 subjects, using a velocity step rotational test. Gain and time constant of the VOR were calculated by computer. During tests, the subjects were required either to perform mental arithmetic or to attempt to follow an imaginary target rotating with them in the dark. Voluntary non-visual suppression of gain was significantly reduced during exposure to N2O, though there was no statistically significant effect of N2O on gain per se. The time constant was unaffected either by voluntary suppression or by N2O. The reducing effect of N2O on voluntary non-visual suppression of VOR... (More)

The effect of subanesthetic nitrous oxide (N2O) narcosis (21%) on the vestibulo-ocular reflex (VOR) and on voluntary non-visual suppression of the VOR was studied in 12 subjects, using a velocity step rotational test. Gain and time constant of the VOR were calculated by computer. During tests, the subjects were required either to perform mental arithmetic or to attempt to follow an imaginary target rotating with them in the dark. Voluntary non-visual suppression of gain was significantly reduced during exposure to N2O, though there was no statistically significant effect of N2O on gain per se. The time constant was unaffected either by voluntary suppression or by N2O. The reducing effect of N2O on voluntary non-visual suppression of VOR gain is assumed to be due to reduced alertness. Reduced voluntary non-visual suppression of VOR may imply reduced visual-vestibular interaction, which might be one explanation of the complaints of dizziness associated with fatigue or with ingestion of certain sedatives.

(Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
keywords
Adult, Female, Humans, Inert Gas Narcosis, Male, Nitrous Oxide, Reflex, Vestibulo-Ocular, Vision, Ocular, Journal Article, Research Support, Non-U.S. Gov't
in
Aviation Space and Environmental Medicine
volume
63
issue
10
pages
6 pages
publisher
Aerospace Medical Association
external identifiers
  • scopus:0026730176
ISSN
0095-6562
language
English
LU publication?
yes
id
ea893f39-71da-474c-9917-347f9df22c97
date added to LUP
2017-05-03 12:35:01
date last changed
2017-09-20 15:24:56
@article{ea893f39-71da-474c-9917-347f9df22c97,
  abstract     = {<p>The effect of subanesthetic nitrous oxide (N2O) narcosis (21%) on the vestibulo-ocular reflex (VOR) and on voluntary non-visual suppression of the VOR was studied in 12 subjects, using a velocity step rotational test. Gain and time constant of the VOR were calculated by computer. During tests, the subjects were required either to perform mental arithmetic or to attempt to follow an imaginary target rotating with them in the dark. Voluntary non-visual suppression of gain was significantly reduced during exposure to N2O, though there was no statistically significant effect of N2O on gain per se. The time constant was unaffected either by voluntary suppression or by N2O. The reducing effect of N2O on voluntary non-visual suppression of VOR gain is assumed to be due to reduced alertness. Reduced voluntary non-visual suppression of VOR may imply reduced visual-vestibular interaction, which might be one explanation of the complaints of dizziness associated with fatigue or with ingestion of certain sedatives.</p>},
  author       = {Padoan, S and Magnusson, M and Akesson, M and Ornhagen, H},
  issn         = {0095-6562},
  keyword      = {Adult,Female,Humans,Inert Gas Narcosis,Male,Nitrous Oxide,Reflex, Vestibulo-Ocular,Vision, Ocular,Journal Article,Research Support, Non-U.S. Gov't},
  language     = {eng},
  number       = {10},
  pages        = {80--875},
  publisher    = {Aerospace Medical Association},
  series       = {Aviation Space and Environmental Medicine},
  title        = {Reduced voluntary non-visual suppression of the vestibulo-ocular reflex gain during nitrous oxide narcosis},
  volume       = {63},
  year         = {1992},
}