Suramin selectively inhibits carcinoma cell growth that is dependent on extracellular polyamines.
(2003) In Anticancer research 23(2B). p.1223-1228- Abstract
- Polyamines are necessary for tumour cell growth. Inhibition of endogenous polyamine biosynthesis results in compensatory up-regulation of polyamine uptake. Here, the combined effect of suramin and the polyamine biosynthesis inhibitor alpha-difluoromethylornithine (DFMO) on human carcinoma cell proliferation was studied. Suramin selectively inhibited the growth of tumour cells made dependent on extracellular polyamines by DFMO-treatment. In an animal tumour model, low non-toxic doses of suramin resulted in a 2-fold increase in DFMO tumour growth reduction. Moreover, suramin bound strongly to polyamine-agarose and significantly inhibited polyamine uptake in DFMO-treated cells. Our results indicate that non-toxic doses of suramin augment... (More)
- Polyamines are necessary for tumour cell growth. Inhibition of endogenous polyamine biosynthesis results in compensatory up-regulation of polyamine uptake. Here, the combined effect of suramin and the polyamine biosynthesis inhibitor alpha-difluoromethylornithine (DFMO) on human carcinoma cell proliferation was studied. Suramin selectively inhibited the growth of tumour cells made dependent on extracellular polyamines by DFMO-treatment. In an animal tumour model, low non-toxic doses of suramin resulted in a 2-fold increase in DFMO tumour growth reduction. Moreover, suramin bound strongly to polyamine-agarose and significantly inhibited polyamine uptake in DFMO-treated cells. Our results indicate that non-toxic doses of suramin augment tumour growth inhibition by DFMO, and that a combination of these well-studied anticancer drugs may represent an additional strategy for cancer treatment. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/115776
- author
- Sandgren, Staffan LU and Belting, Mattias LU
- organization
- publishing date
- 2003
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- alpha-difluoromethylornithine, carcinoma, polyamine, suramin, proteoglycan
- in
- Anticancer research
- volume
- 23
- issue
- 2B
- pages
- 1223 - 1228
- publisher
- International Institute of Cancer Research
- external identifiers
-
- wos:000183471600009
- scopus:0037861867
- ISSN
- 1791-7530
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Cell and Matrix Biology (LUR000002), Oncology, Kamprad Lab (013230901), Oncology, MV (013035000)
- id
- ea901e42-6617-4cc1-a134-94151d32e07e (old id 115776)
- date added to LUP
- 2016-04-01 12:00:58
- date last changed
- 2022-01-26 21:34:04
@article{ea901e42-6617-4cc1-a134-94151d32e07e,
abstract = {{Polyamines are necessary for tumour cell growth. Inhibition of endogenous polyamine biosynthesis results in compensatory up-regulation of polyamine uptake. Here, the combined effect of suramin and the polyamine biosynthesis inhibitor alpha-difluoromethylornithine (DFMO) on human carcinoma cell proliferation was studied. Suramin selectively inhibited the growth of tumour cells made dependent on extracellular polyamines by DFMO-treatment. In an animal tumour model, low non-toxic doses of suramin resulted in a 2-fold increase in DFMO tumour growth reduction. Moreover, suramin bound strongly to polyamine-agarose and significantly inhibited polyamine uptake in DFMO-treated cells. Our results indicate that non-toxic doses of suramin augment tumour growth inhibition by DFMO, and that a combination of these well-studied anticancer drugs may represent an additional strategy for cancer treatment.}},
author = {{Sandgren, Staffan and Belting, Mattias}},
issn = {{1791-7530}},
keywords = {{alpha-difluoromethylornithine; carcinoma; polyamine; suramin; proteoglycan}},
language = {{eng}},
number = {{2B}},
pages = {{1223--1228}},
publisher = {{International Institute of Cancer Research}},
series = {{Anticancer research}},
title = {{Suramin selectively inhibits carcinoma cell growth that is dependent on extracellular polyamines.}},
volume = {{23}},
year = {{2003}},
}