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Examining the validity of the Mini-Mental State Examination (MMSE) and its domains using network analysis

Truong, Quoc Cuong ; Cervin, Matti LU ; Choo, Carol ; Numbers, Katya ; Bentvelzen, Adam ; Kochan, Nicole ; Brodaty, Henry ; Sachdev, Perminder and Medvedev, Oleg N. (2023) In Psychogeriatrics p.1-13
Abstract
Background
The Mini-Mental State Examination (MMSE) is the most widely used standardised screener for impairments across a range of cognitive domains. However, the degree to which its domains (orientation, registration, attention, recall, language, and visuospatial) capture cognitive functioning measured using standardised neuropsychological tests is unclear.

Method
A longitudinal research design with four biannual assessments over a 6-year period was used with an initial sample of 1037 older adults (aged above 70 years). Participants completed MMSE and neuropsychological tests at each assessment. Network analysis was utilised to investigate unique associations among the MMSE and its domains and neuropsychological test... (More)
Background
The Mini-Mental State Examination (MMSE) is the most widely used standardised screener for impairments across a range of cognitive domains. However, the degree to which its domains (orientation, registration, attention, recall, language, and visuospatial) capture cognitive functioning measured using standardised neuropsychological tests is unclear.

Method
A longitudinal research design with four biannual assessments over a 6-year period was used with an initial sample of 1037 older adults (aged above 70 years). Participants completed MMSE and neuropsychological tests at each assessment. Network analysis was utilised to investigate unique associations among the MMSE and its domains and neuropsychological test performance at each time point.

Results
The total MMSE and two of its domains, language and recall, were associated with neuropsychological memory performance. The MMSE orientation, registration and visuospatial domains did not have any unique associations with neuropsychological performance. No stable internal interconnections between MMSE domains were found over time. The association of total MMSE as well as its recall domain with neuropsychological memory performance remained very similar over the 6-year period.

Conclusions
The present study adds evidence to the validity of the MMSE and supports the clinical usage of the MMSE, whereby the total score is used for screening patients with or without cognitive impairments, with repeated administration to monitor cognitive changes over time, to inform intervention. However, the tool is not able to diagnose the cases for changes in specific cognitive domains and as such, should not replace a complete neuropsychological assessment. (Less)
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organization
publishing date
type
Contribution to journal
publication status
epub
subject
in
Psychogeriatrics
pages
1 - 13
publisher
Wiley
external identifiers
  • scopus:85180249096
  • pmid:38131467
ISSN
1346-3500
DOI
10.1111/psyg.13069
language
English
LU publication?
yes
id
eaac83d3-59db-43f2-9797-0019ac0f7651
date added to LUP
2024-01-05 20:01:46
date last changed
2024-04-06 03:00:07
@article{eaac83d3-59db-43f2-9797-0019ac0f7651,
  abstract     = {{Background<br/>The Mini-Mental State Examination (MMSE) is the most widely used standardised screener for impairments across a range of cognitive domains. However, the degree to which its domains (orientation, registration, attention, recall, language, and visuospatial) capture cognitive functioning measured using standardised neuropsychological tests is unclear.<br/><br/>Method<br/>A longitudinal research design with four biannual assessments over a 6-year period was used with an initial sample of 1037 older adults (aged above 70 years). Participants completed MMSE and neuropsychological tests at each assessment. Network analysis was utilised to investigate unique associations among the MMSE and its domains and neuropsychological test performance at each time point.<br/><br/>Results<br/>The total MMSE and two of its domains, language and recall, were associated with neuropsychological memory performance. The MMSE orientation, registration and visuospatial domains did not have any unique associations with neuropsychological performance. No stable internal interconnections between MMSE domains were found over time. The association of total MMSE as well as its recall domain with neuropsychological memory performance remained very similar over the 6-year period.<br/><br/>Conclusions<br/>The present study adds evidence to the validity of the MMSE and supports the clinical usage of the MMSE, whereby the total score is used for screening patients with or without cognitive impairments, with repeated administration to monitor cognitive changes over time, to inform intervention. However, the tool is not able to diagnose the cases for changes in specific cognitive domains and as such, should not replace a complete neuropsychological assessment.}},
  author       = {{Truong, Quoc Cuong and Cervin, Matti and Choo, Carol and Numbers, Katya and Bentvelzen, Adam and Kochan, Nicole and Brodaty, Henry and Sachdev, Perminder and Medvedev, Oleg N.}},
  issn         = {{1346-3500}},
  language     = {{eng}},
  month        = {{12}},
  pages        = {{1--13}},
  publisher    = {{Wiley}},
  series       = {{Psychogeriatrics}},
  title        = {{Examining the validity of the Mini-Mental State Examination (MMSE) and its domains using network analysis}},
  url          = {{http://dx.doi.org/10.1111/psyg.13069}},
  doi          = {{10.1111/psyg.13069}},
  year         = {{2023}},
}