Sphingolipids in the gut? Which are the important issues?
(2007) In European Journal of Lipid Science and Technology 109(10). p.971-976- Abstract
- Glycosphingolipids and sphingomyelin (SM) are important components of the apical brush border and the Golgi and enclocytic vesicles of the gut epithelium. In particular, glucosylceramide is abundant in the microvilli. Synthesis and degradation of mucosal sphingolipids and targeting of sphingolipids to distinct cell compartments during cell differentiation are thus important features of intestinal lipid metabolism. Sphingolipids are also present in the ordinary Western diet, and sphingolipid-rich formulations of dairy, plant or yeast origin are now available for studies of their biological effects in animals and humans. Since sphingolipids account for a large part of the polar lipids in milk, their digestion and effects in the suckling... (More)
- Glycosphingolipids and sphingomyelin (SM) are important components of the apical brush border and the Golgi and enclocytic vesicles of the gut epithelium. In particular, glucosylceramide is abundant in the microvilli. Synthesis and degradation of mucosal sphingolipids and targeting of sphingolipids to distinct cell compartments during cell differentiation are thus important features of intestinal lipid metabolism. Sphingolipids are also present in the ordinary Western diet, and sphingolipid-rich formulations of dairy, plant or yeast origin are now available for studies of their biological effects in animals and humans. Since sphingolipids account for a large part of the polar lipids in milk, their digestion and effects in the suckling infant is of particular interest. Dietary sphingolipids are slowly digested and the exposure of the whole gut to sphingolipids and their metabolites can be increased by dietary supply. Metabolites from dietary sphingolipids may have anti -inflammatory and anticarcinogenic effects and undigested sphingolipids may be protective. Dietary sphingolipids inhibit cholesterol absorption and may have beneficial metabolic effects. Some mucosal sphingolipids have blood group A, B and H reactivity and some act as receptors for bacterial toxins and virus. Sphingolipid signaling triggered by mucosal-bacterial interaction may be important in both the gut and the bronchi. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/653169
- author
- Nilsson, Åke LU
- organization
- publishing date
- 2007
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- ceramidase, digestion, sphingolipids, intestine, sphingomyelinase
- in
- European Journal of Lipid Science and Technology
- volume
- 109
- issue
- 10
- pages
- 971 - 976
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000250496800002
- scopus:35548958212
- ISSN
- 1438-7697
- DOI
- 10.1002/ejlt.200700071
- language
- English
- LU publication?
- yes
- id
- eaf930fd-6564-4b7d-953f-ec41d005e5f2 (old id 653169)
- date added to LUP
- 2016-04-01 12:37:35
- date last changed
- 2024-01-09 03:05:56
@article{eaf930fd-6564-4b7d-953f-ec41d005e5f2,
abstract = {{Glycosphingolipids and sphingomyelin (SM) are important components of the apical brush border and the Golgi and enclocytic vesicles of the gut epithelium. In particular, glucosylceramide is abundant in the microvilli. Synthesis and degradation of mucosal sphingolipids and targeting of sphingolipids to distinct cell compartments during cell differentiation are thus important features of intestinal lipid metabolism. Sphingolipids are also present in the ordinary Western diet, and sphingolipid-rich formulations of dairy, plant or yeast origin are now available for studies of their biological effects in animals and humans. Since sphingolipids account for a large part of the polar lipids in milk, their digestion and effects in the suckling infant is of particular interest. Dietary sphingolipids are slowly digested and the exposure of the whole gut to sphingolipids and their metabolites can be increased by dietary supply. Metabolites from dietary sphingolipids may have anti -inflammatory and anticarcinogenic effects and undigested sphingolipids may be protective. Dietary sphingolipids inhibit cholesterol absorption and may have beneficial metabolic effects. Some mucosal sphingolipids have blood group A, B and H reactivity and some act as receptors for bacterial toxins and virus. Sphingolipid signaling triggered by mucosal-bacterial interaction may be important in both the gut and the bronchi.}},
author = {{Nilsson, Åke}},
issn = {{1438-7697}},
keywords = {{ceramidase; digestion; sphingolipids; intestine; sphingomyelinase}},
language = {{eng}},
number = {{10}},
pages = {{971--976}},
publisher = {{John Wiley & Sons Inc.}},
series = {{European Journal of Lipid Science and Technology}},
title = {{Sphingolipids in the gut? Which are the important issues?}},
url = {{http://dx.doi.org/10.1002/ejlt.200700071}},
doi = {{10.1002/ejlt.200700071}},
volume = {{109}},
year = {{2007}},
}