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Gain of chromosomal region 20q and loss of 18 discriminates between Lynch syndrome and familial colorectal cancer

Therkildsen, Christina ; Jönsson, Göran B LU ; Dominguez, Mev LU ; Nissen, Anja ; Rambech, Eva LU ; Halvarsson, Britta ; Bernstein, Inge ; Borg, Åke LU and Nilbert, Mef LU (2013) In European Journal of Cancer 49(6). p.1226-1235
Abstract
Lynch syndrome and familial colorectal cancer type X, FCCTX, represent the two predominant colorectal cancer syndromes. Whereas Lynch syndrome is clinically and genetically well defined, the genetic cause of FCCTX is unknown and genomic differences between Lynch syndrome and FCCTX tumours are largely unknown. We applied array-based comparative genomic hybridisation to 23 colorectal cancers from FCCTX with comparison to 23 Lynch syndrome tumours and to 45 sporadic colorectal cancers. FCCTX tumours showed genomic complexity with frequent gains on chromosomes 20q, 19 and 17 and losses of 18, 8p and 15. Gain of genetic material in two separate regions encompassing, 20q12-13.12 and 20q13.2-13.32, was identified in 65% of the FCCTX tumours. Gain... (More)
Lynch syndrome and familial colorectal cancer type X, FCCTX, represent the two predominant colorectal cancer syndromes. Whereas Lynch syndrome is clinically and genetically well defined, the genetic cause of FCCTX is unknown and genomic differences between Lynch syndrome and FCCTX tumours are largely unknown. We applied array-based comparative genomic hybridisation to 23 colorectal cancers from FCCTX with comparison to 23 Lynch syndrome tumours and to 45 sporadic colorectal cancers. FCCTX tumours showed genomic complexity with frequent gains on chromosomes 20q, 19 and 17 and losses of 18, 8p and 15. Gain of genetic material in two separate regions encompassing, 20q12-13.12 and 20q13.2-13.32, was identified in 65% of the FCCTX tumours. Gain of material on chromosome 20q and loss on chromosome 18 significantly discriminated colorectal cancers associated with FCCTX from Lynch syndrome, which likely signifies different preferred tumourigenic pathways. (C) 2012 Elsevier Ltd. All rights reserved. (Less)
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author
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Array-based comparative genomic hybridisation, HNPCC, Microsatellite, instability, MMR deficiency
in
European Journal of Cancer
volume
49
issue
6
pages
1226 - 1235
publisher
Elsevier
external identifiers
  • wos:000317188600008
  • scopus:84875731688
  • pmid:23245329
ISSN
1879-0852
DOI
10.1016/j.ejca.2012.11.011
language
English
LU publication?
yes
id
eafb334b-5d09-47c3-a578-8ab0e989d48c (old id 3745258)
date added to LUP
2016-04-01 10:48:36
date last changed
2022-01-26 02:43:59
@article{eafb334b-5d09-47c3-a578-8ab0e989d48c,
  abstract     = {{Lynch syndrome and familial colorectal cancer type X, FCCTX, represent the two predominant colorectal cancer syndromes. Whereas Lynch syndrome is clinically and genetically well defined, the genetic cause of FCCTX is unknown and genomic differences between Lynch syndrome and FCCTX tumours are largely unknown. We applied array-based comparative genomic hybridisation to 23 colorectal cancers from FCCTX with comparison to 23 Lynch syndrome tumours and to 45 sporadic colorectal cancers. FCCTX tumours showed genomic complexity with frequent gains on chromosomes 20q, 19 and 17 and losses of 18, 8p and 15. Gain of genetic material in two separate regions encompassing, 20q12-13.12 and 20q13.2-13.32, was identified in 65% of the FCCTX tumours. Gain of material on chromosome 20q and loss on chromosome 18 significantly discriminated colorectal cancers associated with FCCTX from Lynch syndrome, which likely signifies different preferred tumourigenic pathways. (C) 2012 Elsevier Ltd. All rights reserved.}},
  author       = {{Therkildsen, Christina and Jönsson, Göran B and Dominguez, Mev and Nissen, Anja and Rambech, Eva and Halvarsson, Britta and Bernstein, Inge and Borg, Åke and Nilbert, Mef}},
  issn         = {{1879-0852}},
  keywords     = {{Array-based comparative genomic hybridisation; HNPCC; Microsatellite; instability; MMR deficiency}},
  language     = {{eng}},
  number       = {{6}},
  pages        = {{1226--1235}},
  publisher    = {{Elsevier}},
  series       = {{European Journal of Cancer}},
  title        = {{Gain of chromosomal region 20q and loss of 18 discriminates between Lynch syndrome and familial colorectal cancer}},
  url          = {{http://dx.doi.org/10.1016/j.ejca.2012.11.011}},
  doi          = {{10.1016/j.ejca.2012.11.011}},
  volume       = {{49}},
  year         = {{2013}},
}