Constitutional trisomy 8 mosaicism as a model for epigenetic studies of aneuploidy.
Davidsson, Josef LU ; Veerla, Srinivas LU
and Johansson, Bertil
LU
(2013)
In Epigenetics & Chromatin
6(1).
- Abstract
- To investigate epigenetic patterns associated with aneuploidy we used constitutional trisomy 8 mosaicism (CT8M) as a model, enabling analyses of single cell clones, harboring either trisomy or disomy 8, from the same patient; this circumvents any bias introduced by using cells from unrelated, healthy individuals as controls. We profiled gene and miRNA expression as well as genome-wide and promoter specific DNA methylation and hydroxymethylation patterns in trisomic and disomic fibroblasts, using microarrays and methylated DNA immunoprecipitation.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/3956290
- author
- Davidsson, Josef
LU
; Veerla, Srinivas
LU
and Johansson, Bertil
LU
- organization
- publishing date
- 2013
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Epigenetics & Chromatin
- volume
- 6
- issue
- 1
- article number
- 18
- publisher
- BioMed Central (BMC)
- external identifiers
-
- wos:000321376400001
- pmid:23816241
- scopus:84879465690
- pmid:23816241
- ISSN
- 1756-8935
- DOI
- 10.1186/1756-8935-6-18
- language
- English
- LU publication?
- yes
- id
- eb04de37-180d-442c-8257-f5ddae468e18 (old id 3956290)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/23816241?dopt=Abstract
- date added to LUP
- 2016-04-01 13:39:33
- date last changed
- 2024-01-09 16:28:31
@article{eb04de37-180d-442c-8257-f5ddae468e18,
abstract = {{To investigate epigenetic patterns associated with aneuploidy we used constitutional trisomy 8 mosaicism (CT8M) as a model, enabling analyses of single cell clones, harboring either trisomy or disomy 8, from the same patient; this circumvents any bias introduced by using cells from unrelated, healthy individuals as controls. We profiled gene and miRNA expression as well as genome-wide and promoter specific DNA methylation and hydroxymethylation patterns in trisomic and disomic fibroblasts, using microarrays and methylated DNA immunoprecipitation.}},
author = {{Davidsson, Josef and Veerla, Srinivas and Johansson, Bertil}},
issn = {{1756-8935}},
language = {{eng}},
number = {{1}},
publisher = {{BioMed Central (BMC)}},
series = {{Epigenetics & Chromatin}},
title = {{Constitutional trisomy 8 mosaicism as a model for epigenetic studies of aneuploidy.}},
url = {{https://lup.lub.lu.se/search/files/3511173/4146448}},
doi = {{10.1186/1756-8935-6-18}},
volume = {{6}},
year = {{2013}},
}