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Constitutional trisomy 8 mosaicism as a model for epigenetic studies of aneuploidy.

Davidsson, Josef LU ; Veerla, Srinivas LU and Johansson, Bertil LU (2013) In Epigenetics & Chromatin 6(1).
Abstract
To investigate epigenetic patterns associated with aneuploidy we used constitutional trisomy 8 mosaicism (CT8M) as a model, enabling analyses of single cell clones, harboring either trisomy or disomy 8, from the same patient; this circumvents any bias introduced by using cells from unrelated, healthy individuals as controls. We profiled gene and miRNA expression as well as genome-wide and promoter specific DNA methylation and hydroxymethylation patterns in trisomic and disomic fibroblasts, using microarrays and methylated DNA immunoprecipitation.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Epigenetics & Chromatin
volume
6
issue
1
article number
18
publisher
BioMed Central
external identifiers
  • wos:000321376400001
  • pmid:23816241
  • scopus:84879465690
  • pmid:23816241
ISSN
1756-8935
DOI
10.1186/1756-8935-6-18
language
English
LU publication?
yes
id
eb04de37-180d-442c-8257-f5ddae468e18 (old id 3956290)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/23816241?dopt=Abstract
date added to LUP
2016-04-01 13:39:33
date last changed
2020-01-12 13:10:31
@article{eb04de37-180d-442c-8257-f5ddae468e18,
  abstract     = {To investigate epigenetic patterns associated with aneuploidy we used constitutional trisomy 8 mosaicism (CT8M) as a model, enabling analyses of single cell clones, harboring either trisomy or disomy 8, from the same patient; this circumvents any bias introduced by using cells from unrelated, healthy individuals as controls. We profiled gene and miRNA expression as well as genome-wide and promoter specific DNA methylation and hydroxymethylation patterns in trisomic and disomic fibroblasts, using microarrays and methylated DNA immunoprecipitation.},
  author       = {Davidsson, Josef and Veerla, Srinivas and Johansson, Bertil},
  issn         = {1756-8935},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Epigenetics & Chromatin},
  title        = {Constitutional trisomy 8 mosaicism as a model for epigenetic studies of aneuploidy.},
  url          = {https://lup.lub.lu.se/search/ws/files/3511173/4146448},
  doi          = {10.1186/1756-8935-6-18},
  volume       = {6},
  year         = {2013},
}