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Can reducing cosmetic substances help prevent chromate contact allergy?

Lejding, Tina LU ; Engfeldt, Malin LU ; Bruze, Magnus LU ; Isaksson, Marléne LU ; Persson , Lena LU ; Svedman, Cecilia LU ; Zimerson, Erik LU and Mowitz, Martin LU (2020) In Contact Dermatitis 82(1). p.39-44
Abstract

Background: Allergic contact dermatitis caused by Cr(VI) is often severe and difficult to treat. Therefore, primary prevention is a main goal but secondary prevention can be valuable to ease the symptoms or prevent relapse of Cr(VI) dermatitis when sensitization has occurred. Barrier creams have been tried for many chemical substances, but until now there is no successful barrier cream against Cr(VI). Objectives: To investigate the ability of reducing agents to transform Cr(VI) into Cr(III) in an experimental situation, in order to find suitable chemicals to investigate for possible use in a barrier cream. Methods: The capacity to reduce the amount of Cr(VI) was analyzed in water solutions of acetylcysteine, cysteine, dihydroxyacetone,... (More)

Background: Allergic contact dermatitis caused by Cr(VI) is often severe and difficult to treat. Therefore, primary prevention is a main goal but secondary prevention can be valuable to ease the symptoms or prevent relapse of Cr(VI) dermatitis when sensitization has occurred. Barrier creams have been tried for many chemical substances, but until now there is no successful barrier cream against Cr(VI). Objectives: To investigate the ability of reducing agents to transform Cr(VI) into Cr(III) in an experimental situation, in order to find suitable chemicals to investigate for possible use in a barrier cream. Methods: The capacity to reduce the amount of Cr(VI) was analyzed in water solutions of acetylcysteine, cysteine, dihydroxyacetone, glutathione, and iron sulfate heptahydrate. Thereafter the reducing capacity of acetylcysteine, dihydroxyacetone, glutathione, and iron sulfate on the amount of Cr(VI) in cement extracts was investigated. The content of Cr(VI) in the test solutions and in the cement extracts was estimated by the diphenyl carbazide spot test. Results: All of the chosen chemicals reduced the amount of Cr(VI) in the test solutions and in the cement extracts to some extent. The reducing capacity was most prominent for iron sulfate. Conclusion: A reducing capacity was found for all chosen chemicals.

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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
allergic contact dermatitis, barrier cream, chromate, Cr(VI), hexavalent chromium, reducing chemicals
in
Contact Dermatitis
volume
82
issue
1
pages
39 - 44
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • pmid:31652346
  • scopus:85075421738
ISSN
0105-1873
DOI
10.1111/cod.13426
language
English
LU publication?
yes
id
eb181fa0-2454-40ac-b037-b1839422db21
date added to LUP
2019-12-06 14:05:39
date last changed
2020-01-16 04:08:15
@article{eb181fa0-2454-40ac-b037-b1839422db21,
  abstract     = {<p>Background: Allergic contact dermatitis caused by Cr(VI) is often severe and difficult to treat. Therefore, primary prevention is a main goal but secondary prevention can be valuable to ease the symptoms or prevent relapse of Cr(VI) dermatitis when sensitization has occurred. Barrier creams have been tried for many chemical substances, but until now there is no successful barrier cream against Cr(VI). Objectives: To investigate the ability of reducing agents to transform Cr(VI) into Cr(III) in an experimental situation, in order to find suitable chemicals to investigate for possible use in a barrier cream. Methods: The capacity to reduce the amount of Cr(VI) was analyzed in water solutions of acetylcysteine, cysteine, dihydroxyacetone, glutathione, and iron sulfate heptahydrate. Thereafter the reducing capacity of acetylcysteine, dihydroxyacetone, glutathione, and iron sulfate on the amount of Cr(VI) in cement extracts was investigated. The content of Cr(VI) in the test solutions and in the cement extracts was estimated by the diphenyl carbazide spot test. Results: All of the chosen chemicals reduced the amount of Cr(VI) in the test solutions and in the cement extracts to some extent. The reducing capacity was most prominent for iron sulfate. Conclusion: A reducing capacity was found for all chosen chemicals.</p>},
  author       = {Lejding, Tina and Engfeldt, Malin and Bruze, Magnus and Isaksson, Marléne and Persson , Lena  and Svedman, Cecilia and Zimerson, Erik and Mowitz, Martin},
  issn         = {0105-1873},
  language     = {eng},
  number       = {1},
  pages        = {39--44},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Can reducing cosmetic substances help prevent chromate contact allergy?},
  url          = {http://dx.doi.org/10.1111/cod.13426},
  doi          = {10.1111/cod.13426},
  volume       = {82},
  year         = {2020},
}