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Heritability of optic disc diameters: a twin study

Dragana, Drobnjak ; Taarnhøj, Nina Charlotte Bille Brahe ; Mitchell, Paul ; Wang, Jie J ; Tang, Ava ; Kessel, Line ; Hougaard, Jesper Leth LU ; Sørensen, Thorkild I A and Larsen, Michael (2011) In Acta Ophthalmologica 89(2). p.193-198
Abstract (Swedish)
Abstract
PURPOSE: To assess the relative influence of genetic and environmental factors on optic disc size and cup/disc ratio in healthy eyes. METHODS: A sample of 55 monozygotic and 50 dizygotic healthy twin pairs aged 20-46, all having the same sex within pairs (47 pairs were male) had optic discs measured from colour fundus photographs according to the Wisconsin Protocol. Structural equation modelling was used to estimate the relative contribution of genetic and environmental factors to the phenotype. RESULTS: Disc dimensions did not vary significantly by age or sex. After adjusting for age and sex, additive genetic factors (i.e. heritability) explained 77% (95% CI: 65-85%) of variation of vertical disc diameters, whereas estimated... (More)
Abstract
PURPOSE: To assess the relative influence of genetic and environmental factors on optic disc size and cup/disc ratio in healthy eyes. METHODS: A sample of 55 monozygotic and 50 dizygotic healthy twin pairs aged 20-46, all having the same sex within pairs (47 pairs were male) had optic discs measured from colour fundus photographs according to the Wisconsin Protocol. Structural equation modelling was used to estimate the relative contribution of genetic and environmental factors to the phenotype. RESULTS: Disc dimensions did not vary significantly by age or sex. After adjusting for age and sex, additive genetic factors (i.e. heritability) explained 77% (95% CI: 65-85%) of variation of vertical disc diameters, whereas estimated unshared environmental effect was 23% (95% CI: 15-35%). For vertical cup diameters, heritability accounted for 70% (95% CI: 55-80%) and environmental factors 30% (95% CI: 20-45%). For cup/disc ratio, additive genetic and unshared environmental factors explained 66% (95% CI: 48-77%) and 34% (95% CI: 23-52%) of the variations, respectively. DISCUSSION: In this healthy twin sample, we found that three quarters of the variations in vertical optic disc and optic cup diameters were attributable to genetic influence. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
Acta Ophthalmologica
volume
89
issue
2
pages
193 - 198
publisher
Wiley-Blackwell
external identifiers
  • scopus:79952225376
ISSN
1755-3768
DOI
10.1111/j.1755-3768.2010.01923.x
language
English
LU publication?
no
id
eb4fa121-1d1d-4307-b20c-b0cc714df4f5
date added to LUP
2019-06-13 10:44:59
date last changed
2020-01-13 02:00:03
@article{eb4fa121-1d1d-4307-b20c-b0cc714df4f5,
  abstract     = {Abstract<br/>PURPOSE: To assess the relative influence of genetic and environmental factors on optic disc size and cup/disc ratio in healthy eyes. METHODS: A sample of 55 monozygotic and 50 dizygotic healthy twin pairs aged 20-46, all having the same sex within pairs (47 pairs were male) had optic discs measured from colour fundus photographs according to the Wisconsin Protocol. Structural equation modelling was used to estimate the relative contribution of genetic and environmental factors to the phenotype. RESULTS: Disc dimensions did not vary significantly by age or sex. After adjusting for age and sex, additive genetic factors (i.e. heritability) explained 77% (95% CI: 65-85%) of variation of vertical disc diameters, whereas estimated unshared environmental effect was 23% (95% CI: 15-35%). For vertical cup diameters, heritability accounted for 70% (95% CI: 55-80%) and environmental factors 30% (95% CI: 20-45%). For cup/disc ratio, additive genetic and unshared environmental factors explained 66% (95% CI: 48-77%) and 34% (95% CI: 23-52%) of the variations, respectively. DISCUSSION: In this healthy twin sample, we found that three quarters of the variations in vertical optic disc and optic cup diameters were attributable to genetic influence.},
  author       = {Dragana, Drobnjak and Taarnhøj, Nina Charlotte Bille Brahe and Mitchell, Paul  and Wang, Jie J  and Tang, Ava and Kessel, Line and Hougaard, Jesper Leth and Sørensen, Thorkild I A and Larsen, Michael},
  issn         = {1755-3768},
  language     = {eng},
  number       = {2},
  pages        = {193--198},
  publisher    = {Wiley-Blackwell},
  series       = {Acta Ophthalmologica},
  title        = {Heritability of optic disc diameters: a twin study},
  url          = {http://dx.doi.org/10.1111/j.1755-3768.2010.01923.x},
  doi          = {10.1111/j.1755-3768.2010.01923.x},
  volume       = {89},
  year         = {2011},
}