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Gamma-Glutamyl Transferase, Intestinal Alkaline Phosphatase and Beta-Hexosaminidase Activity in Duodenal Biopsies from Chronic Alcoholics

Hauge, Truls LU ; Nilsson, Åke LU ; Persson, Jesper and Hultberg, Björn (1998) In Hepatogastroenterology 45(22). p.985-989
Abstract
BACKGROUND/AIMS: Gamma-glutamyl transferase (GGT) and intestinal alkaline phosphatase (IAP) are present in the brush border of mucosal absorptive cells in the small intestine. There are few studies on the effect of alcohol consumption on these enzymes. Increased intestinal GGT in biopsy specimens from the duodenum has been described in chronic alcoholics. In experimental animals alcohol effects varies with duration of exposure and with nutritional factors.METHODOLOGY: IAP, GGT and the lysosomal enzyme beta-hexosaminidase (Hex) were examined in duodenal biopsy specimens from 23 defined chronic alcoholics and 33 non alcoholic controls. The results were correlated to serum GGT, alkaline phosphatase, CDT (Carbohydrate Deficient Transferrin)... (More)
BACKGROUND/AIMS: Gamma-glutamyl transferase (GGT) and intestinal alkaline phosphatase (IAP) are present in the brush border of mucosal absorptive cells in the small intestine. There are few studies on the effect of alcohol consumption on these enzymes. Increased intestinal GGT in biopsy specimens from the duodenum has been described in chronic alcoholics. In experimental animals alcohol effects varies with duration of exposure and with nutritional factors.METHODOLOGY: IAP, GGT and the lysosomal enzyme beta-hexosaminidase (Hex) were examined in duodenal biopsy specimens from 23 defined chronic alcoholics and 33 non alcoholic controls. The results were correlated to serum GGT, alkaline phosphatase, CDT (Carbohydrate Deficient Transferrin) and the villus index.RESULTS: Both the intestinal GGT (0.52 + 0.05 SEM vs. 0.30 + 0.024 SEM microkat/g protein, p<0.0001) and the IAP (22.11 + 2.49 SEM vs. 12.28 + 1.35 SEM microkat/g protein, p=0.0010) were significantly higher in alcoholics than in controls. There was no correlation between intestinal and serum alkaline phosphatase and GGT activity within the two groups.CONCLUSIONS: Chronic alcohol consumption causes increased intestinal GGT and IAP activity in man. No effect on Hex was seen. The enzyme activity in the small intestine did not correlate to serum enzyme activity or to morphological changes in the small intestine. (Less)
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author
; ; and
organization
publishing date
type
Contribution to journal
publication status
published
in
Hepatogastroenterology
volume
45
issue
22
article number
9755994
pages
5 pages
external identifiers
  • scopus:0031693479
language
English
LU publication?
yes
id
eb670eae-597c-49d2-a26c-1a4f973d5b55
date added to LUP
2019-05-27 22:04:40
date last changed
2024-01-01 07:52:51
@article{eb670eae-597c-49d2-a26c-1a4f973d5b55,
  abstract     = {{BACKGROUND/AIMS: Gamma-glutamyl transferase (GGT) and intestinal alkaline phosphatase (IAP) are present in the brush border of mucosal absorptive cells in the small intestine. There are few studies on the effect of alcohol consumption on these enzymes. Increased intestinal GGT in biopsy specimens from the duodenum has been described in chronic alcoholics. In experimental animals alcohol effects varies with duration of exposure and with nutritional factors.METHODOLOGY: IAP, GGT and the lysosomal enzyme beta-hexosaminidase (Hex) were examined in duodenal biopsy specimens from 23 defined chronic alcoholics and 33 non alcoholic controls. The results were correlated to serum GGT, alkaline phosphatase, CDT (Carbohydrate Deficient Transferrin) and the villus index.RESULTS: Both the intestinal GGT (0.52 + 0.05 SEM vs. 0.30 + 0.024 SEM microkat/g protein, p&lt;0.0001) and the IAP (22.11 + 2.49 SEM vs. 12.28 + 1.35 SEM microkat/g protein, p=0.0010) were significantly higher in alcoholics than in controls. There was no correlation between intestinal and serum alkaline phosphatase and GGT activity within the two groups.CONCLUSIONS: Chronic alcohol consumption causes increased intestinal GGT and IAP activity in man. No effect on Hex was seen. The enzyme activity in the small intestine did not correlate to serum enzyme activity or to morphological changes in the small intestine.}},
  author       = {{Hauge, Truls and Nilsson, Åke and Persson, Jesper and Hultberg, Björn}},
  language     = {{eng}},
  month        = {{07}},
  number       = {{22}},
  pages        = {{985--989}},
  series       = {{Hepatogastroenterology}},
  title        = {{Gamma-Glutamyl Transferase, Intestinal Alkaline Phosphatase and Beta-Hexosaminidase Activity in Duodenal Biopsies from Chronic Alcoholics}},
  volume       = {{45}},
  year         = {{1998}},
}