Modelling the combined effects of collagen and cyclic strain on cellular orientation in collagenous tissues
(2018) In Scientific Reports 8(1).- Abstract
Adherent cells are generally able to reorient in response to cyclic strain. In three-dimensional tissues, however, extracellular collagen can affect this cellular response. In this study, a computational model able to predict the combined effects of mechanical stimuli and collagen on cellular (re)orientation was developed. In particular, a recently proposed computational model (which only accounts for mechanical stimuli) was extended by considering two hypotheses on how collagen influences cellular (re)orientation: Collagen contributes to cell alignment by providing topographical cues (contact guidance); or collagen causes a spatial obstruction for cellular reorientation (steric hindrance). In addition, we developed an evolution law to... (More)
Adherent cells are generally able to reorient in response to cyclic strain. In three-dimensional tissues, however, extracellular collagen can affect this cellular response. In this study, a computational model able to predict the combined effects of mechanical stimuli and collagen on cellular (re)orientation was developed. In particular, a recently proposed computational model (which only accounts for mechanical stimuli) was extended by considering two hypotheses on how collagen influences cellular (re)orientation: Collagen contributes to cell alignment by providing topographical cues (contact guidance); or collagen causes a spatial obstruction for cellular reorientation (steric hindrance). In addition, we developed an evolution law to predict cell-induced collagen realignment. The hypotheses were tested by simulating bi-or uniaxially constrained cell-populated collagen gels with different collagen densities, subjected to immediate or delayed uniaxial cyclic strain with varying strain amplitudes. The simulation outcomes are in agreement with previous experimental reports. Taken together, our computational approach is a promising tool to understand and predict the remodeling of collagenous tissues, such as native or tissue-engineered arteries and heart valves.
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- author
- Ristori, T. ; Notermans, T. M.W. LU ; Foolen, J. ; Kurniawan, N. A. ; Bouten, C. V.C. ; Baaijens, F. P.T. and Loerakker, S.
- publishing date
- 2018-12-01
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Scientific Reports
- volume
- 8
- issue
- 1
- article number
- 8518
- publisher
- Nature Publishing Group
- external identifiers
-
- scopus:85048148833
- pmid:29867153
- ISSN
- 2045-2322
- DOI
- 10.1038/s41598-018-26989-y
- language
- English
- LU publication?
- no
- id
- eb73a979-4a1e-45f6-97ba-c12abbbe4a09
- date added to LUP
- 2019-04-01 09:25:57
- date last changed
- 2024-07-10 11:39:46
@article{eb73a979-4a1e-45f6-97ba-c12abbbe4a09,
abstract = {{<p>Adherent cells are generally able to reorient in response to cyclic strain. In three-dimensional tissues, however, extracellular collagen can affect this cellular response. In this study, a computational model able to predict the combined effects of mechanical stimuli and collagen on cellular (re)orientation was developed. In particular, a recently proposed computational model (which only accounts for mechanical stimuli) was extended by considering two hypotheses on how collagen influences cellular (re)orientation: Collagen contributes to cell alignment by providing topographical cues (contact guidance); or collagen causes a spatial obstruction for cellular reorientation (steric hindrance). In addition, we developed an evolution law to predict cell-induced collagen realignment. The hypotheses were tested by simulating bi-or uniaxially constrained cell-populated collagen gels with different collagen densities, subjected to immediate or delayed uniaxial cyclic strain with varying strain amplitudes. The simulation outcomes are in agreement with previous experimental reports. Taken together, our computational approach is a promising tool to understand and predict the remodeling of collagenous tissues, such as native or tissue-engineered arteries and heart valves.</p>}},
author = {{Ristori, T. and Notermans, T. M.W. and Foolen, J. and Kurniawan, N. A. and Bouten, C. V.C. and Baaijens, F. P.T. and Loerakker, S.}},
issn = {{2045-2322}},
language = {{eng}},
month = {{12}},
number = {{1}},
publisher = {{Nature Publishing Group}},
series = {{Scientific Reports}},
title = {{Modelling the combined effects of collagen and cyclic strain on cellular orientation in collagenous tissues}},
url = {{http://dx.doi.org/10.1038/s41598-018-26989-y}},
doi = {{10.1038/s41598-018-26989-y}},
volume = {{8}},
year = {{2018}},
}