Factors associated with health-related quality of life among adults with tetralogy of Fallot
(2019) In Open Heart 6(1).- Abstract
Background Due to improved care, the numbers of patients with tetralogy of Fallot (ToF) are increasing. However, long-term morbidity and need for reinterventions are concerns and also address issues of quality of life (QoL). Methods Patients with ToF and valid EuroQol-5 dimensions questionnaire (EQ-5D) were identified in the national Swedish register on congenital heart disease. EQ-5D index was calculated and dichotomised into best possible health-related QoL (EQ-5D index =1) or differed from 1. Results 288 patients met the criteria and were analysed. Univariate logistic regression showed a positive association between New York Heart Association (NYHA) class I (OR 8.32, 95% CI 3.80 to 18.21), physical activity >3 h/week (OR 3.34, 95%... (More)
Background Due to improved care, the numbers of patients with tetralogy of Fallot (ToF) are increasing. However, long-term morbidity and need for reinterventions are concerns and also address issues of quality of life (QoL). Methods Patients with ToF and valid EuroQol-5 dimensions questionnaire (EQ-5D) were identified in the national Swedish register on congenital heart disease. EQ-5D index was calculated and dichotomised into best possible health-related QoL (EQ-5D index =1) or differed from 1. Results 288 patients met the criteria and were analysed. Univariate logistic regression showed a positive association between New York Heart Association (NYHA) class I (OR 8.32, 95% CI 3.80 to 18.21), physical activity >3 h/week (OR 3.34, 95% CI 1.67 to 6.66) and a better right ventricular function (OR 2.56, 95% CI 1.09 to 6.02). A negative association between symptoms (OR 0.23, 95% CI 0.13 to 0.42), cardiovascular medication (OR 0.31, 95% CI 0.18 to 0.53), age (OR 0.97, 95% CI 0.96 to 0.99) and EQ-5D index was observed. In multivariate logistic regression, NYHA I (OR 7.28, 95% CI 3.29 to 16.12) and physical activity >3 h/week (OR 2.27, 95% CI 1.07 to 4.84) remained associated with best possible health-related QoL. Replacing NYHA with symptoms in the model yielded similar results. Conclusion In this registry study, self-reported physical activity, staff-reported NYHA class and absence of symptoms were strongly associated with best possible health-related QoL measured by EQ-5D. Physical activity level is a potential target for intervention to improve QoL in this population but randomised trials are needed to test such a hypothesis.
(Less)
- author
- Sandtröm, Anette ; Sandberg, Camilla ; Rinnström, Daniel ; Engström, Gunnar ; Dellborg, Mikael ; Thilén, Ulf LU ; Sörensson, Peder ; Nielsen, Niels Erik ; Christersson, Christina and Johansson, Bengt LU
- organization
- publishing date
- 2019-02-27
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- congenital heart disease, physical activity, quality of life, register, tetralogy of fallot
- in
- Open Heart
- volume
- 6
- issue
- 1
- article number
- e000932
- publisher
- BMJ Publishing Group
- external identifiers
-
- pmid:30997127
- scopus:85062271422
- ISSN
- 2053-3624
- DOI
- 10.1136/openhrt-2018-000932
- language
- English
- LU publication?
- yes
- id
- eb7abd44-1f05-4a7e-b398-64dad8b62522
- date added to LUP
- 2019-03-13 13:28:56
- date last changed
- 2024-04-01 23:21:36
@article{eb7abd44-1f05-4a7e-b398-64dad8b62522,
abstract = {{<p>Background Due to improved care, the numbers of patients with tetralogy of Fallot (ToF) are increasing. However, long-term morbidity and need for reinterventions are concerns and also address issues of quality of life (QoL). Methods Patients with ToF and valid EuroQol-5 dimensions questionnaire (EQ-5D) were identified in the national Swedish register on congenital heart disease. EQ-5D index was calculated and dichotomised into best possible health-related QoL (EQ-5D index =1) or differed from 1. Results 288 patients met the criteria and were analysed. Univariate logistic regression showed a positive association between New York Heart Association (NYHA) class I (OR 8.32, 95% CI 3.80 to 18.21), physical activity >3 h/week (OR 3.34, 95% CI 1.67 to 6.66) and a better right ventricular function (OR 2.56, 95% CI 1.09 to 6.02). A negative association between symptoms (OR 0.23, 95% CI 0.13 to 0.42), cardiovascular medication (OR 0.31, 95% CI 0.18 to 0.53), age (OR 0.97, 95% CI 0.96 to 0.99) and EQ-5D index was observed. In multivariate logistic regression, NYHA I (OR 7.28, 95% CI 3.29 to 16.12) and physical activity >3 h/week (OR 2.27, 95% CI 1.07 to 4.84) remained associated with best possible health-related QoL. Replacing NYHA with symptoms in the model yielded similar results. Conclusion In this registry study, self-reported physical activity, staff-reported NYHA class and absence of symptoms were strongly associated with best possible health-related QoL measured by EQ-5D. Physical activity level is a potential target for intervention to improve QoL in this population but randomised trials are needed to test such a hypothesis.</p>}},
author = {{Sandtröm, Anette and Sandberg, Camilla and Rinnström, Daniel and Engström, Gunnar and Dellborg, Mikael and Thilén, Ulf and Sörensson, Peder and Nielsen, Niels Erik and Christersson, Christina and Johansson, Bengt}},
issn = {{2053-3624}},
keywords = {{congenital heart disease; physical activity; quality of life; register; tetralogy of fallot}},
language = {{eng}},
month = {{02}},
number = {{1}},
publisher = {{BMJ Publishing Group}},
series = {{Open Heart}},
title = {{Factors associated with health-related quality of life among adults with tetralogy of Fallot}},
url = {{http://dx.doi.org/10.1136/openhrt-2018-000932}},
doi = {{10.1136/openhrt-2018-000932}},
volume = {{6}},
year = {{2019}},
}